Sanotac ISP Series Intelligent High-Pressure Constant Flow Pump

Overview

The Sanotac ISP Series Intelligent High-Pressure Constant Flow Pump is an engineered solution for precision fluid delivery in demanding laboratory and industrial process environments. Based on dual-servo-driven parallel plunger architecture, the ISP pump operates on positive displacement principles with active electronic pulse suppression and cam-profiled motion control—ensuring stable, low-pulsation flow across its full operational range. Unlike conventional peristaltic or diaphragm pumps, the ISP series delivers true constant-flow performance under variable backpressure conditions up to 42 MPa, making it suitable for high-pressure liquid chromatography (HPLC), supercritical fluid applications, microreactor feed systems, catalytic reaction monitoring, and closed-loop gravimetric dosing setups. Its modular firmware design supports both standalone operation and seamless integration into larger automation frameworks—including distributed control systems (DCS), supervisory control and data acquisition (SCADA), and programmable logic controllers (PLC)—with native support for industry-standard communication protocols.

Key Features

• Dual-servo parallel plunger head design with real-time solvent compressibility compensation and multi-point flow calibration for <±0.5% repeatability (model-dependent)
• Configurable pressure protection: independent upper/lower limit thresholds with automatic shutdown and alarm logging
• Low-pulsation delivery achieved via optimized cam trajectory + digital flow pulse suppression algorithm
• Real-time dual-curve visualization: synchronized pressure vs. time and flow rate vs. time plots displayed on integrated LCD interface
• Programmable piston post-wash cycle to prevent salt crystallization and seal degradation in aqueous or buffer-based mobile phases
• Flexible unit handling: volumetric (mL/min) and mass-based (g/min) flow control modes, with user-defined density mapping
• Comprehensive I/O connectivity: RS-232, RS-485, RS-422, and USB interfaces; supports Modbus RTU/ASCII and custom ASCII protocol stacks
• Scalable control topology: single-pump mode, binary gradient mixing, or cascaded multi-pump configurations (1 master : up to 32 slaves)
• Onboard data logging: pressure and flow time-series exportable to Excel-compatible .xlsx files with timestamped metadata
• User-configurable parameter storage: retains serial port settings, pressure limits, flow programs, and calibration offsets across power cycles

Sample Compatibility & Compliance

The ISP Series accommodates a broad spectrum of chemically aggressive and viscous fluids—including organic solvents (acetonitrile, THF, DMSO), aqueous buffers (pH 1–13), ionic liquids, and suspensions with particulates ≤5 µm. Wetted materials include sapphire-ruby check valves, Hastelloy C-276 pump heads, and PEEK/PTFE fluid paths—ensuring compatibility with USP Class VI and FDA-compliant applications. All models meet CE electromagnetic compatibility (EMC) Directive 2014/30/EU and Low Voltage Directive 2014/35/EU requirements. Firmware includes audit-trail-ready event logging (start/stop, pressure fault, calibration changes), supporting GLP/GMP-aligned workflows where traceability is mandated. Optional 21 CFR Part 11-compliant software modules are available for regulated pharmaceutical and clinical research environments.

Software & Data Management

Sanotac provides the ISP Control Suite—a cross-platform application (Windows/macOS/Linux) enabling remote configuration, real-time monitoring, script-based method sequencing, and batch export of operational logs. The suite supports OPC UA server deployment for enterprise-level data federation and integrates with LabArchives, Benchling, and ELN platforms via RESTful API endpoints. Raw time-series data is stored in open CSV format with ISO 8601 timestamps and SI-unit annotations, facilitating third-party analysis in MATLAB, Python (Pandas), or JMP. For embedded integration, the pump’s serial command set includes deterministic response timing (<10 ms latency), CRC-16 error checking, and non-blocking asynchronous query support—enabling deterministic control loops in real-time process automation.

Applications

• HPLC and UHPLC system integration as primary or auxiliary solvent delivery modules
• Continuous-flow chemistry: precise reagent metering into micro/meso-scale reactors under elevated temperature and pressure
• Materials science: controlled precursor injection in sol-gel synthesis, atomic layer deposition (ALD), and CVD precursor delivery
• Environmental testing: automated eluent delivery in ion chromatography (IC) and trace metal analysis systems
• Pharmaceutical R&D: formulation stability studies requiring long-duration, low-drift infusion (e.g., IV bag simulation, dissolution testing)
• Gravimetric closed-loop control: interfacing with METTLER TOLEDO or Sartorius analytical balances for loss-in-weight feeding systems
• Nuclear fuel cycle research: handling radioactive solutions under shielded glovebox environments with remote diagnostics

FAQ

What pressure ranges are supported across the ISP model lineup?
ISP models span 0–10 MPa (ILP0110, ISP6010) to 0–42 MPa (IAP0010), with intermediate options at 15, 20, 30, and 42 MPa maximum ratings—each validated per ISO 5171:2019 hydraulic endurance standards.
Can the pump be integrated into a PLC-controlled manufacturing line?
Yes. Native Modbus RTU over RS-485 enables direct register mapping to Siemens S7, Rockwell Logix, or Mitsubishi Q-series PLCs without gateway hardware.
Is flow calibration traceable to NIST standards?
While the pump itself is not NIST-certified, Sanotac provides documented calibration procedures using gravimetric reference methods compliant with ASTM D3427 and ISO 4064-2, allowing users to establish in-house traceability.
Does the system support gradient formation with multiple pumps?
Yes—up to four ISP units can be synchronized in binary or ternary gradient mode via master-slave timing signals or software-coordinated ramp profiles.
What maintenance intervals are recommended for high-pressure operation (>30 MPa)?
Plunger seals require replacement every 1,000 hours at ≥30 MPa continuous duty; check valve inspection is advised every 500 hours. Full service kits and torque-spec tools are supplied with OEM documentation.