Cole-Parmer Masterflex L/S 6-Channel Syringe Pump System (Model 75900-55)

Overview

The Cole-Parmer Masterflex L/S 6-Channel Syringe Pump System (Model 75900-55) is a precision-engineered, multi-syringe fluid delivery platform designed for demanding laboratory and industrial applications requiring synchronized, programmable, and highly reproducible volumetric dosing. Unlike conventional peristaltic or piston-driven pumps, this system employs independent stepper-motor-driven linear actuators for each of its six channels—enabling true parallel operation with full individual control over injection, withdrawal, direction reversal, pause intervals, and flow profile sequencing. Its architecture is grounded in open-loop microstepping control with calibrated mechanical feedback, ensuring consistent displacement accuracy across the full syringe volume range (1–60 mL). The pump operates on a deterministic timing model: volume delivery is calculated directly from motor step count, lead screw pitch, and syringe barrel cross-sectional area—minimizing dependency on fluid viscosity or backpressure within rated operational limits. This makes it particularly suitable for low-to-medium pressure applications such as reagent addition in automated synthesis, cell culture media perfusion, chromatography sample introduction, and multi-stream calibration standard preparation.

Key Features

• Six independently controllable syringe channels with simultaneous bidirectional operation (infuse/withdraw)
• Large backlit LCD interface supporting intuitive programming of up to 41 discrete commands per sequence—including variable flow rates, dwell times, directional toggles, and conditional pauses
• Persistent memory retention: all program settings, current position, and runtime state are preserved through power interruption and cold reboot
• User-lockout mode prevents unauthorized modification of critical parameters—essential for GLP-compliant environments and shared-core facilities
• High-force actuation: delivers 45.4 kgf linear thrust at minimum speed, enabling reliable operation with high-viscosity fluids and narrow-bore tubing
• Multi-unit synchronization: RS-485 daisy-chain architecture supports coordinated control of up to 100 pump units with built-in CRC-based error detection to mitigate EMI-induced communication faults
• Integrated purge cycle function for rapid air removal and syringe priming without manual intervention
• Configurable end-of-program alarm output (audible + relay contact) for unattended operation integration

Sample Compatibility & Compliance

The Model 75900-55 accommodates standard Luer-lock syringes ranging from 1 mL to 60 mL capacity, including glass, polypropylene, and stainless-steel variants compatible with organic solvents, aqueous buffers, and mild acids/bases. All wetted components meet USP Class VI biocompatibility requirements. The system complies with CE marking directives (2014/30/EU EMC Directive and 2014/35/EU Low Voltage Directive) and conforms to IEC 61000-6-2/6-3 immunity and emission standards. While not intrinsically safe, it is suitable for use in ISO Class 5–8 cleanrooms when paired with appropriate enclosures. No FDA 510(k) clearance or ISO 13485 certification applies, as the device is classified as general-purpose laboratory instrumentation—not a medical device under 21 CFR Part 820.

Software & Data Management

No proprietary PC software is required for basic operation; all functions are accessible via front-panel interface. For advanced automation, the pump supports ASCII-based serial command protocol over RS-485, enabling integration with LabVIEW, Python (pySerial), MATLAB, or custom SCADA systems. Command logging and execution timestamps are retained internally for audit trail generation. While native data export is not supported, external PLCs or host computers can poll status registers (e.g., current volume delivered, elapsed time, error flags) at user-defined intervals. The system does not implement FDA 21 CFR Part 11 electronic signature or audit trail features; however, its deterministic command structure and persistent memory allow third-party software layers to reconstruct full operational history when deployed in validated workflows.

Applications

• Automated multi-reagent addition in parallel reaction screening and combinatorial chemistry setups
• Controlled nutrient/media exchange in bioreactors and microfluidic organ-on-chip platforms
• Calibration standard preparation for ICP-MS, HPLC, and GC-MS laboratories requiring trace-level dilution series
• Sequential solvent delivery in gradient elution systems and preparative chromatography
• Long-duration infusion studies in pharmacokinetic modeling and in vitro dissolution testing
• Multi-channel dialysis buffer exchange and ultrafiltration support in protein purification workflows

FAQ

What syringe sizes are supported?
Standard Luer-lock syringes from 1 mL to 60 mL; compatibility verified with BD, Hamilton, and SGE brands.
Can flow rate be adjusted dynamically during a program?
Yes—each of the 41 programmable steps may specify unique flow rates, directions, and dwell durations.
Is the pump suitable for sterile applications?
It is not autoclavable, but syringe barrels and tubing may be sterilized separately; the pump body is cleanroom-compatible with proper housing.
Does it support analog input/output for external triggering?
No—only digital RS-485 communication is provided; TTL or 0–10 V I/O requires external interface modules.
How is accuracy maintained across different syringe diameters?
Users must manually enter syringe inner diameter (ID) during setup; the firmware calculates displacement per motor step based on entered ID and selected units.