Sanotac SP1110 High-Pressure Binary Prep LC Pump (1000 mL/min, 10 MPa)

Overview

The Sanotac SP1110 is a high-performance binary high-pressure preparative liquid chromatography (prep LC) pump engineered for robust, scalable fluid delivery in demanding analytical and process-scale applications. Operating on a dual-piston parallel architecture with floating piston design, it delivers precise, pulse-minimized solvent flow across an exceptionally wide dynamic range—from 0.1 mL/min to 1000 mL/min—while maintaining stable pressure control up to 10 MPa (1450 psi). Its core hydraulic principle relies on positive displacement via precision-machined ceramic and ruby components, coupled with wear-resistant PTFE and 316L stainless steel wetted surfaces, ensuring compatibility with aggressive organic solvents, aqueous buffers, and corrosive mobile phases commonly used in reversed-phase, ion-exchange, size-exclusion, and post-column derivatization workflows. Designed for integration into modular chromatography platforms—including HPLC, IC, GPC, amino acid analyzers, HbA1c systems, IVD instruments, and lab-scale continuous-flow reactors—the SP1110 meets the mechanical reliability and regulatory traceability requirements of GLP-compliant laboratories and early-stage process development environments.

Key Features

• Dual-piston parallel pumping mechanism with dynamically balanced floating piston assembly for extended service life and reduced mechanical hysteresis
• Multi-point flow calibration across full range (0.1–1000 mL/min), enabling ±0.5% absolute accuracy and ≤0.1% RSD repeatability per ISO 11607-2 and ASTM D3418 validation protocols
• Active flow pulsation suppression via cam-profile compensation and real-time electronic feedback control, limiting pressure ripple to ≤0.2 MPa (typ.)
• Integrated plunger back-flush function using dedicated wash solvent channel to minimize seal wear and prevent crystallization-induced leakage
• Configurable wetted path options: standard 316L stainless steel; optional Hastelloy C-276, PEEK, PTFE, or PCTFE for halogenated, acidic, or high-pH mobile phases
• Standard 1/8″ Swagelok-compatible fluidic connections with leak-tight sealing verified per ISO 8503-2 surface roughness specifications
• Self-luminous 256×64 dot-matrix LCD display with real-time graphical plotting of flow vs. pressure trends and program execution progress bar

Sample Compatibility & Compliance

The SP1110 supports broad chemical compatibility across pharmaceutical, biotech, and industrial QC applications. Its fluidic path materials comply with USP Class VI and FDA CFR 21 Part 11 material eligibility guidelines for contact with drug substances and excipients. When configured with PEEK or PTFE components, it accommodates pH 0–14 mobile phases and solvents including TFA, HFIP, concentrated phosphoric acid, and acetonitrile/water mixtures at elevated temperatures. The pump’s mechanical design conforms to IEC 61000-6-2 (EMC immunity) and IEC 61010-1 (safety for laboratory equipment). Firmware supports audit trail logging, user-level access control, and electronic signature capability—enabling alignment with 21 CFR Part 11 Annex 11 and EU GMP Annex 11 requirements when deployed in regulated environments.

Software & Data Management

The SP1110 features native support for Modbus RTU/ASCII, Profibus DP, and Profinet protocols alongside Sanotac’s proprietary ASCII-based command set. It interfaces seamlessly with SCADA, DCS, and PLC systems via RS-232 (standard), RS-485/422 (optional), USB 2.0, or Ethernet (via external converter). Onboard firmware enables analog input (0–5 V / 4–20 mA) for external flow setpoint modulation and digital I/O for remote start/stop and fault signaling. The embedded software suite permits unit switching between volumetric (mL/min) and gravimetric (g/min) delivery modes, multi-segment gradient programming (linear, step, custom curve), real-time data streaming to CSV/Excel, method storage for ≥50 protocols, and factory reset with parameter rollback. Optional remote desktop client provides secure TLS-encrypted monitoring and control over LAN/WAN networks.

Applications

• Preparative purification of synthetic intermediates, natural products, and oligonucleotides (up to 100 g scale)
• Mobile phase delivery for ion chromatography systems analyzing anions/cations in environmental water samples
• Isocratic and gradient elution in gel permeation chromatography (GPC) for polymer molecular weight distribution analysis
• Reagent metering in post-column derivatization modules for amino acid and carbohydrate detection
• Controlled reagent infusion in automated HbA1c analyzers and clinical IVD platforms
• Continuous-flow chemistry setups requiring precise stoichiometric dosing under backpressure
• Integration into PAT (Process Analytical Technology) frameworks for real-time reaction monitoring

FAQ

What is the maximum operating pressure of the SP1110 pump?
The SP1110 is rated for continuous operation up to 10 MPa (1450 psi) with appropriate column and tubing selection.
Can the pump be used with aggressive solvents such as trifluoroacetic acid (TFA) or hydrofluoric acid (HF)?
Yes—when equipped with PTFE, PEEK, or Hastelloy C-276 wetted parts, it maintains integrity in highly corrosive media; consult material compatibility charts prior to use.
Does the SP1110 support gradient mixing?
As a binary pump, it requires external low-dead-volume mixing tee or integrated mixer module for gradient formation; it does not include onboard proportioning valves.
Is firmware upgrade supported in-field?
Yes—firmware updates are performed via USB stick or serial interface using Sanotac’s certified utility software with version rollback capability.
What regulatory documentation is provided with the instrument?
Each unit ships with Factory Acceptance Test (FAT) report, material compliance certificates (RoHS, REACH), CE Declaration of Conformity, and optional IQ/OQ documentation templates compliant with ISO/IEC 17025.