Sartorius Quintix 125D-1CN Analytical Balance (Dual-Range, 0.01 mg / 0.1 mg Readability)

Overview

The Sartorius Quintix 125D-1CN is a high-precision dual-range analytical balance engineered for laboratories requiring trace-level mass measurement under variable operational demands. Based on electromagnetic force compensation (EMFC) technology, it delivers stable, drift-compensated weighing performance across two distinct capacity ranges—60 g at 0.01 mg readability and 120 g at 0.1 mg readability—enabling seamless transition between ultra-micro and standard analytical tasks without hardware reconfiguration. Designed and assembled in Shanghai under Sartorius’ global quality management system (ISO 9001 certified), the instrument integrates temperature- and time-triggered isoCAL internal calibration to counteract thermal drift and mechanical hysteresis—critical factors affecting long-term stability in regulated environments such as pharmaceutical QC labs, contract research organizations (CROs), and academic metrology facilities.

Key Features

• Electromagnetic force compensation (EMFC) sensor architecture with active damping and auto-zero tracking for high reproducibility (≤ ±0.01 mg at 60 g range)
• Dual-range operation: 60 g / 0.01 mg and 120 g / 0.1 mg—optimized for both high-resolution micro-weighing and broader sample handling
• isoCAL: Fully automated internal calibration and adjustment, triggered by predefined temperature thresholds (±1.5 °C) or user-defined intervals; all calibration events logged in Cal Audit Trail
• USB direct data transfer: Plug-and-play connectivity to Windows-based PCs; exports real-time weight values directly into Microsoft Excel® as formatted numeric or text fields—no third-party drivers or configuration required
• Integrated application suite: Includes formulation weighing (with individual component tracking), statistical analysis (mean, SD, CV, min/max), density determination (for solid samples), checkweighing, percentage weighing, piece counting, and peak-hold mode for obstructed readouts
• Rugged mechanical design validated via ≥1,000,000-cycle load stress testing in Sartorius’ certified simulation chamber—ensuring structural integrity and metrological consistency over extended service life

Sample Compatibility & Compliance

The Quintix 125D-1CN accommodates standard analytical vessels—including weighing boats, crucibles, and tared containers—within its 180 mm diameter draft shield aperture. Its draft shield assembly meets ISO 17025 requirements for environmental isolation during sub-milligram measurements. The balance supports GLP/GMP workflows through full audit trail functionality: every calibration, zeroing, tare, and application event is timestamped, user-ID tagged, and non-erasable when enabled. Data export complies with FDA 21 CFR Part 11 standards when used with validated IT infrastructure, including electronic signature support and role-based access control via optional Sartorius LabX software integration.

Software & Data Management

Native USB HID protocol enables immediate recognition as a human interface device—eliminating driver installation. Weight data streams directly into spreadsheet cells or LIMS fields without intermediate parsing. For advanced traceability, optional LabX software provides centralized instrument control, automated report generation (PDF/CSV), electronic signature enforcement, and full 21 CFR Part 11 compliance—including secure audit trails, change control logs, and data integrity validation. All internal calibration records are stored locally in encrypted memory and exportable in CSV format for external QA review.

Applications

• Pharmaceutical dosage form development: Precise formulation of APIs and excipients with 100% batch traceability per USP and EP 2.1.3
• Reference material certification: Mass assignment of certified reference materials (CRMs) per ISO Guide 34 and ISO/IEC 17025
• Materials science: Density determination of irregular solids using Archimedes’ principle with integrated buoyancy correction
• Quality control laboratories: Checkweighing against tolerance bands per ISO 2854 and ASTM E1054
• Academic research: Statistical evaluation of replicate samples (n ≥ 10) with automatic calculation of RSD, confidence intervals, and outlier detection
• Regulated manufacturing: Piece counting of tablets/capsules with dynamic average piece weight stabilization and deviation alerting

FAQ

Does the Quintix 125D-1CN meet ISO/IEC 17025 requirements for accredited testing laboratories?
Yes—the balance includes isoCAL audit logging, repeatability verification protocols, and environmental monitoring compatibility essential for ISO/IEC 17025 accreditation.
Can the balance be integrated into a 21 CFR Part 11–compliant workflow?
Yes—when paired with LabX software and configured with appropriate IT controls (e.g., electronic signatures, audit trail retention, user authentication), it satisfies core Part 11 criteria for electronic records and signatures.
What is the purpose of the “unstable weighing” function?
This mode applies adaptive filtering algorithms to dampen oscillatory signals caused by vibration, airflow, or live biological samples (e.g., rodents), delivering stabilized readings without manual intervention.
Is external calibration required in addition to isoCAL?
While isoCAL ensures ongoing accuracy, periodic verification with traceable external weights (e.g., Class E2 or better) is recommended per ISO 17025 clause 6.5 and USP to confirm metrological validity.
How does the formulation application ensure full traceability?
Each component entry is timestamped, assigned a unique ID, and linked to final total mass—generating an immutable record suitable for regulatory submission and internal audit.