Shimadzu LCMS-8060 Triple Quadrupole Liquid Chromatography-Mass Spectrometer
| Origin | Guangdong, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Domestic (PRC) |
| Model | LCMS-8060 |
| Pricing | Available Upon Request |
Overview
The Shimadzu LCMS-8060 is a high-performance triple quadrupole liquid chromatography-mass spectrometer engineered for quantitative bioanalysis, environmental monitoring, food safety testing, and pharmaceutical quality control. It operates on the principle of electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), coupled with tandem mass spectrometry (MS/MS) in multiple reaction monitoring (MRM) mode. The instrument delivers exceptional sensitivity, speed, and robustness through fundamental improvements in ion optics, vacuum architecture, and detector design—enabling reliable detection and quantification of trace-level analytes in complex matrices.
Key Features
- Ultra-Fast Qarray (UF-Qarray) Ion Guide: A proprietary ion-focusing technology that enhances ion transmission efficiency across the entire m/z range while minimizing neutral background and chemical noise. This design improves signal-to-noise ratios by optimizing ion trajectory and reducing scattering losses in the first vacuum stage.
- High-Speed Polarity Switching: Capable of switching between positive and negative ion modes in less than 5 milliseconds, supporting comprehensive multi-analyte assays without compromising cycle time or data fidelity.
- Advanced Collision Cell (UF-Lightning): Delivers rapid, stable, and reproducible fragmentation with minimized cross-talk and enhanced duty cycle—critical for high-throughput MRM workflows.
- Robust Vacuum Architecture: Dual-stage differential pumping system with optimized conductance paths ensures stable operation under variable LC flow rates (0.01–2.0 mL/min) and extended uptime during unattended batch runs.
- Integrated LC Compatibility: Fully compatible with Shimadzu Nexera UHPLC systems—including binary and quaternary gradient pumps, autosamplers with needle-wash and temperature control, and column ovens—ensuring seamless method transfer and system synchronization.
Sample Compatibility & Compliance
The LCMS-8060 accommodates a broad range of sample types, including plasma, serum, urine, tissue homogenates, plant extracts, water, soil digests, and processed food matrices. Its hardware and software support compliance with internationally recognized regulatory frameworks: ASTM D7622 (petroleum hydrocarbon analysis), ISO 17025 (testing laboratory competence), USP <621> (chromatography), and FDA 21 CFR Part 11 (electronic records and signatures). Data integrity is reinforced via audit-trail-enabled acquisition software, user-access controls, and electronic signature functionality—fully aligned with GLP and GMP documentation requirements.
Software & Data Management
Controlled by LabSolutions LCMS software (v5.9 or later), the LCMS-8060 supports method development, acquisition, processing, and reporting within a single integrated environment. Key capabilities include automated MRM optimization, dynamic dwell time adjustment, scheduled MRM, and post-acquisition peak integration with customizable baseline algorithms. Raw data files adhere to open-standard formats (e.g., .qgd, .lcd) and are exportable to third-party platforms such as Simca-P+, MassHunter, or OpenMS for multivariate statistical analysis. All software modules undergo periodic validation per internal SOPs and support IQ/OQ/PQ documentation packages for regulated laboratories.
Applications
- Pharmaceutical: Quantitative pharmacokinetic (PK) and toxicokinetic (TK) studies; impurity profiling; stability-indicating assays; extractable/leachable analysis.
- Clinical Research: Biomarker verification in human biofluids; therapeutic drug monitoring (TDM); newborn screening metabolites.
- Environmental: Pesticide residue screening in surface water and sediment; PFAS analysis in drinking water; dioxin congener quantification.
- Food & Agriculture: Mycotoxin detection in cereals; veterinary drug residues in meat and milk; adulterant identification in botanical supplements.
- Forensics: Illicit drug confirmation in blood and hair; doping agent screening in urine per WADA guidelines.
FAQ
Is the LCMS-8060 compliant with 21 CFR Part 11?
Yes—the LabSolutions LCMS software includes full 21 CFR Part 11 functionality, including role-based access control, electronic signatures, and immutable audit trails for all acquisition and processing events.
What LC systems are certified for use with the LCMS-8060?
Shimadzu Nexera X2 (LC-30AD/30ADSP), Nexera UC (for SFC-MS coupling), and Prominence-i (LC-2030C 3D) systems are fully validated and supported; third-party UHPLC systems may be interfaced via analog/digital I/O or API protocols.
Does the LCMS-8060 support retrospective data reprocessing?
Yes—raw data files retain full scan and MRM metadata, enabling re-extraction of chromatograms, re-integration of peaks, and re-optimization of transitions without re-injection.
What maintenance intervals are recommended for routine operation?
Ion source cleaning every 7–14 days (depending on matrix complexity), turbo pump oil replacement every 12 months, and annual preventive maintenance by Shimadzu-certified engineers are advised to ensure long-term performance stability.
Can the LCMS-8060 be integrated into a LIMS environment?
Yes—via standard ODBC connectivity and configurable CSV/XML export templates, enabling direct data ingestion into major LIMS platforms including Thermo Fisher SampleManager, LabWare LIMS, and STARLIMS.
