METTLER TOLEDO MA204/A Analytical Balance

Overview

The METTLER TOLEDO MA204/A Analytical Balance is a high-precision laboratory instrument engineered for demanding quantitative weighing tasks in regulated and research-intensive environments. It operates on electromagnetic force compensation (EMFC) technology — a proven, drift-resistant transduction principle that delivers stable, reproducible measurements by balancing the gravitational force of the sample against a precisely controlled electromagnetic field. With 0.1 mg readability (100 µg), a 220 g maximum capacity, and linearity error of ±0.2 mg, the MA204/A meets the stringent performance criteria required for analytical chemistry, pharmaceutical development, food safety testing, and quality control laboratories. Its design conforms to international metrological standards including OIML R76 and NTEP Class I, enabling both scientific measurement and legally admissible trade-related weighing. The balance’s fast stabilization time (≤2 seconds) and robust environmental tolerance — operating reliably between 10–30 °C and 20–80% RH (non-condensing) — ensure consistent throughput in dynamic lab settings.

Key Features

• Electromagnetic Force Compensation (EMFC) sensor architecture delivering long-term stability, minimal drift, and high reproducibility (repeatability ≤0.08 mg, typical)
• Internal motorized calibration system with certified test weights — one-touch initiation eliminates manual handling, reduces contamination risk, and ensures traceable calibration integrity
• High-contrast, responsive LCD touchscreen interface with intuitive navigation and guided applications (e.g., formulation weighing, percentage weighing, density determination)
• QuickLock™ draft shield — tool-free removal of all glass panels and drip tray; components are dishwasher-safe to support rigorous cleaning protocols in GxP environments
• Metal base and PBT polymer housing provide mechanical rigidity and resistance to common laboratory chemicals, including diluted acids and bases
• Front-mounted bubble level indicator and adjustable feet facilitate rapid leveling verification — a prerequisite for accurate mass measurement per ISO/IEC 17025 and USP <41>

Sample Compatibility & Compliance

The MA204/A supports a broad range of sample types — from hygroscopic powders and volatile solvents to dense solids and viscous suspensions — thanks to its optimized draft shield geometry and low-vibration isolation platform. Its minimum weight capability (160 mg at USP <0.1% tolerance; 16 mg at k=2, U=1%) enables compliant weighing of low-mass reference standards and active pharmaceutical ingredients (APIs). Regulatory alignment extends across multiple frameworks: OIML R76 and NTEP certification validate legal-for-trade functionality; built-in audit trail capabilities (when used with EasyDirect Balance software) satisfy FDA 21 CFR Part 11 requirements for electronic records and signatures; and full compatibility with GLP/GMP documentation workflows ensures seamless integration into quality management systems.

Software & Data Management

Data integrity is maintained through dual-channel connectivity: standard USB-A and RS232 ports enable direct output to printers, LIMS, or local PCs without middleware. Optional Bluetooth module supports wireless integration into automated data capture ecosystems. When paired with METTLER TOLEDO’s EasyDirect Balance software, the MA204/A delivers centralized management for up to 10 balances — including real-time data synchronization, customizable report templates (PDF/CSV/XLSX), and secure user access control. The software enforces role-based permissions, automatic timestamping, and immutable audit trails — essential for regulatory inspections under ISO 17025, ICH Q7, or EU Annex 11. All raw weighing events, calibration logs, and user actions are retained with full metadata (operator ID, timestamp, instrument ID, environmental conditions if logged).

Applications

This analytical balance serves as a foundational measurement tool across disciplines requiring traceable, high-fidelity mass determination. In pharmaceutical R&D, it supports API quantification, excipient blending verification, and dissolution sample preparation. In food testing labs, it enables precise moisture content analysis (per AOAC 950.46), nutrient labeling compliance, and allergen threshold verification. Environmental and chemical laboratories rely on its repeatability for gravimetric analysis of particulate matter (PM₂.₅ filters), catalyst loading, and standard solution preparation. Additionally, its NTEP/OIML certification allows deployment in production-scale quality assurance where batch release decisions depend on legally defensible weight data.

FAQ

What is the minimum weight this balance can reliably measure?
For USP <0.1% tolerance applications (e.g., pharmacopeial assays), the minimum weight is 160 mg. For general laboratory use with expanded uncertainty (k=2, U=1%), the minimum weight is 16 mg.
Does the MA204/A support GLP-compliant data recording?
Yes — when used with EasyDirect Balance software, it provides full 21 CFR Part 11 compliance, including electronic signatures, audit trails, and secure data export.
Can the draft shield be cleaned in a dishwasher?
Yes — all QuickLock™ glass panels and the removable drip tray are dishwasher-safe, supporting routine decontamination in regulated labs.
Is external calibration required?
No — the internal motorized calibration system uses traceable, factory-certified weights; external calibration is only necessary for periodic verification or after physical relocation.
What environmental conditions affect measurement accuracy?
Operation outside 10–30 °C or >80% RH (with condensation) may impact repeatability; vibration, air currents, and electrostatic charge should also be mitigated per ISO 17025 Section 6.4.