Agilent 7500cx ICP-MS System (Refurbished)

Overview

The Agilent 7500cx ICP-MS is a high-sensitivity, quadrupole-based inductively coupled plasma mass spectrometer engineered for ultra-trace elemental and isotopic analysis across diverse sample matrices. Operating on the fundamental principle of ion generation in a high-temperature Ar plasma (~7,000 K), followed by mass separation via a radiofrequency-driven quadrupole mass filter and detection using a dual-mode electron multiplier (analog and pulse counting), the 7500cx delivers sub-part-per-quadrillion (ppq) detection limits for most elements. Its robust design incorporates a collision/reaction cell (CRC) with He or H₂ gas modes to mitigate polyatomic interferences—particularly critical for analyses of As, Se, Fe, Ca, and K in complex environmental or biological digests. As a refurbished system fully validated by SpectraLab Scientific, this unit meets functional performance criteria per Agilent’s original factory specifications and is calibrated against NIST-traceable multi-element standards prior to shipment.

Key Features

• Quadrupole mass analyzer with mass range 5–280 u and <1 amu resolution
• Dual-mode detector enabling seamless switching between analog (high-concentration) and pulse-counting (ultra-low-level) detection
• Integrated collision/reaction cell (CRC) supporting kinetic energy discrimination (KED) and reactive gas chemistry (H₂, He)
• High-efficiency sample introduction system including PFA microflow nebulizer, quartz cyclonic spray chamber, and Ni sampler/skimmer cones
• Real-time interference monitoring via internal standardization (e.g., Rh, In, Bi) and on-mass background correction
• Comprehensive diagnostic suite including plasma ignition status, vacuum integrity logs, and detector gain verification

Sample Compatibility & Compliance

The 7500cx accommodates liquid samples (aqueous acids, organic solvents, diluted digests) within standard concentration ranges of 0.1 ppq to 100 ppm, with minimal sample volume requirements (10–100 µL per analysis). It supports EPA Methods 200.8 and 6020B, ASTM D5673 (for drinking water), and ISO 17294-2 for environmental testing. All refurbished units undergo GLP-aligned operational qualification (OQ), including mass calibration stability, sensitivity verification (e.g., 10⁶ cps/ppq for In), oxide ratio (<2%), and doubly charged ion ratio (<3%). Documentation includes full OQ reports traceable to NIST SRM 3100 series standards, compliant with FDA 21 CFR Part 11 audit trail requirements for data integrity.

Software & Data Management

Controlled via Agilent MassHunter Workstation Software (v10.x or later), the system provides method development tools for dwell time optimization, peak hopping, and interference correction algorithms. Data acquisition supports time-resolved analysis (TRA) for laser ablation ICP-MS integration and transient signal deconvolution. All raw data (.d files) are stored with embedded metadata—including instrument parameters, calibration history, and user authentication logs—ensuring full traceability. Export formats include CSV, Excel, and XML for LIMS integration. Audit trails record all method modifications, data reprocessing events, and user logins, satisfying ISO/IEC 17025 clause 7.7 and GMP Annex 11 expectations.

Applications

• Environmental monitoring: Quantification of heavy metals (Pb, Cd, Hg, U) and rare earth elements in groundwater, seawater, soil extracts, and fly ash per EPA 200.8
• Semiconductor manufacturing: Detection of metallic contaminants (Na, Al, Fe, Cu) at ≤10¹⁰ atoms/cm² levels in ultrapure water and etchant solutions
• Clinical and nutritional research: Isotopic ratio measurement (e.g., ⁸⁷Sr/⁸⁶Sr) in serum, urine, and tissue digests under CLIA-compliant workflows
• Geochemical fingerprinting: Multi-isotope analysis (Li, B, Mg, Sr, Nd) in silicate melts and mineral leachates
• Nuclear safeguards: Uranium and plutonium isotopic composition determination in swipe samples (IAEA Technical Report Series No. 441)
• Petrochemical QA/QC: Vanadium, nickel, and iron speciation in crude oil fractions following ASTM D6217

FAQ

Is this unit covered by original Agilent factory warranty?

No—this is a professionally refurbished system with a 90-day comprehensive hardware and software functionality warranty administered by SpectraLab Scientific.
Does the system include consumables and spare parts?

Yes—the delivery includes one set of Ni sampler/skimmer cones, PFA nebulizer, quartz spray chamber, and standard torch assembly. Additional consumables are available upon request.
Can the instrument be configured for regulatory compliance (e.g., 21 CFR Part 11)?

Yes—MassHunter v10.0+ supports electronic signatures, audit trail activation, and role-based access control when deployed on validated Windows OS environments.
What documentation accompanies the instrument?

A complete package includes OQ report, calibration certificates (NIST-traceable), software installation media, user manuals, and refurbishment certification signed by certified Agilent service engineers.
Is remote support and application assistance available post-purchase?

Yes—SpectraLab Scientific provides 30 days of complimentary remote application support and method optimization guidance for routine environmental and semiconductor protocols.