Chu Ding Technology DG-24 Manual Vacuum-Assisted Solid Phase Extraction System

Overview

The Chu Ding Technology DG-24 Manual Vacuum-Assisted Solid Phase Extraction System is a benchtop, multi-channel SPE manifold engineered for reproducible, scalable sample preparation in analytical laboratories. It operates on vacuum-assisted gravity flow principles—applying controlled negative pressure across stacked solid-phase extraction cartridges to accelerate solvent passage while maintaining consistent bed integrity and minimizing channeling. Unlike automated or positive-pressure systems, the DG-24 relies on manually adjustable vacuum regulation via integrated needle valves, enabling precise, stepwise elution control critical for method development and regulatory-compliant workflows. Designed for routine use in environmental, food safety, clinical toxicology, and pharmaceutical QC labs, the system supports standardized SPE protocols aligned with EPA Method 500/600 series, ISO 17025-accredited procedures, and USP chromatographic sample preparation guidelines.

Key Features

• 24-position parallel processing capability for high-throughput sample preparation without cross-contamination.
• Individual needle-valve control per channel ensures independent flow rate adjustment (0.1–30 mL/min), essential for optimizing retention and elution across diverse sorbent chemistries (e.g., C18, silica, SCX, SAX, NH₂).
• Chemically inert wetted path constructed entirely from polytetrafluoroethylene (PTFE), offering exceptional resistance to organic solvents (acetonitrile, methanol, dichloromethane), acids, and bases—eliminating leaching and preserving analyte integrity.
• Modular vacuum manifold with sealed gasket interface and dual-stage vacuum port compatibility (standard lab vacuum pump or optional diaphragm pump with regulator).
• Compact footprint (230 × 160 × 180 mm) and lightweight design (~3 kg) facilitate integration into fume hoods, laminar flow cabinets, or shared instrument benches.
• Universal receiver support accommodates standard 16 mm OD collection tubes, 15 mL and 50 mL centrifuge tubes, and 4–20 mL autosampler vials—reducing need for transfer steps and associated losses.

Sample Compatibility & Compliance

The DG-24 is validated for liquid-phase SPE applications involving aqueous matrices (drinking water, wastewater, urine, plasma extracts) and solvent-diluted extracts (e.g., QuEChERS supernatants). It accommodates all commercially available 1 mL, 3 mL, and 6 mL SPE cartridges—including bonded-phase, mixed-mode, and molecularly imprinted polymers (MIPs). While primarily intended for liquid samples, it may be used with homogenized solid extracts after filtration or centrifugation. The PTFE construction complies with FDA-recommended material compatibility standards for residual solvent contact, and the manual operation mode supports full traceability under GLP and GMP environments when paired with documented SOPs and logbook entries. No electronic data capture or audit trail functionality is embedded; users are responsible for maintaining procedural records per 21 CFR Part 11 requirements.

Software & Data Management

The DG-24 is a fully manual, hardware-only system with no onboard electronics, firmware, or software interface. All operational parameters—including vacuum level, flow timing, solvent sequence, and fraction collection—are recorded externally by the user. This architecture eliminates validation overhead associated with computerized systems while ensuring full transparency and operator control. Laboratories implementing LIMS or ELN platforms may map DG-24 usage directly into workflow templates using custom-defined fields for cartridge lot numbers, solvent batches, and elution volumes. No drivers, APIs, or connectivity options are provided.

Applications

• Environmental analysis: Isolation and concentration of PAHs, PCBs, organochlorine pesticides, and perfluoroalkyl substances (PFAS) from surface water and groundwater per EPA 525.3 and ISO 19105.
• Food and agricultural testing: Cleanup of fruit, vegetable, and grain extracts prior to GC-MS/MS or LC-MS/MS quantification of multi-residue pesticide panels (EU SANTE/11312/2021).
• Clinical and forensic toxicology: Selective enrichment of basic drugs (e.g., amphetamines, opioids) and acidic metabolites (e.g., benzoylecgonine) from biological fluids using mixed-mode cation/anion exchange cartridges.
• Pharmaceutical quality control: Removal of excipients and degradation products from tablet dissolution samples prior to HPLC-UV assay.
• Research-scale method development: Rapid screening of sorbent types, wash solvents, and elution gradients without automation constraints.

FAQ

Is the DG-24 compatible with 12 mL SPE cartridges?
Yes—the manifold accepts cartridges up to 20 mm in diameter and 100 mm in length when used with optional height-adjustable support plates (sold separately).
Can I connect the DG-24 to a house vacuum line?
Yes, provided the line delivers stable pressure ≤ −0.1 MPa and includes an inline moisture trap and particulate filter to prevent contamination of the manifold seals.
Does the system include vacuum tubing and connectors?
Standard configuration includes PTFE-coated stainless steel needles, silicone vacuum tubing (4 mm ID), and barbed fittings for immediate setup.
What maintenance is required?
Routine cleaning of PTFE manifolds with methanol followed by air drying; periodic inspection of valve O-rings for compression set; replacement recommended annually under continuous use.
Is technical support available internationally?
Chu Ding Technology provides remote troubleshooting documentation and application notes in English; local distributor support varies by region—contact authorized partners for calibration and service contracts.