QSE-12 Solid Phase Extraction Instrument
| Origin | Tianjin, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Domestic (PRC) |
| Model | QSE-12 |
| Pricing | Available Upon Request |
Overview
The QSE-12 Solid Phase Extraction Instrument is a benchtop vacuum-assisted SPE system engineered for reproducible, high-throughput sample preparation in analytical laboratories. It operates on the principle of selective adsorption and elution—utilizing solid-phase sorbent cartridges or disks to isolate target analytes from complex liquid matrices (e.g., water, plasma, urine, food extracts) while removing interfering substances. Designed for compatibility with standard 1 mL–6 mL SPE cartridges and 47 mm disks, the QSE-12 supports method development and routine quantification workflows aligned with EPA Method 500/525, ASTM D7839, ISO 17993, and USP <621> chromatographic sample prep guidelines.
Key Features
- Vacuum manifold with borosilicate glass vacuum chamber—molded from high-strength tempered glass with uniform wall thickness, rated for continuous operation at ≤85 kPa negative pressure (≥638 mmHg)
- Cross-contamination–resistant design: individual port isolation with integrated anti-misting valve geometry prevents aerosol carryover between channels during solvent aspiration
- Modular cartridge support tray fabricated from ultra-high-molecular-weight polyethylene (UHMW-PE), offering chemical resistance to acetonitrile, methanol, dichloromethane, and 0.1 M NaOH; maintains dimensional stability under sustained vacuum load
- Flexible sample throughput: accommodates simultaneous processing of up to 12 cartridges or sequential single-column operation via independent port control
- Expandable collection interface: compatible with standard 15 mL, 50 mL, and 125 mL conical-bottom centrifuge tubes as well as custom large-volume reservoirs (up to 500 mL) for trace analyte enrichment
- Ergonomic vacuum regulation: dual-stage precision needle valve enables fine-tuned flow control across low-viscosity (e.g., aqueous buffers) and high-viscosity (e.g., plasma digestates) samples
Sample Compatibility & Compliance
The QSE-12 is validated for use with reversed-phase (C18, C8), ion-exchange (SCX, SAX), and mixed-mode sorbents from major suppliers (e.g., Waters, Agilent, Phenomenex, Thermo Fisher). It supports sample volumes ranging from 0.5 mL to 2 L, enabling both micro-scale bioanalytical cleanup and environmental water monitoring protocols. All wetted components comply with ISO 8573-1 purity class 4 for compressed air interfaces (when used with external vacuum pumps), and the system architecture conforms to GLP documentation requirements—including audit-trail–ready operation logs when paired with certified vacuum controllers meeting FDA 21 CFR Part 11 electronic record criteria.
Software & Data Management
While the QSE-12 operates as a standalone hardware platform, its vacuum parameters and run sequencing are fully integrable with laboratory information management systems (LIMS) via analog 0–10 V or digital RS-485 output (optional accessory module). When deployed alongside validated SOP-driven workflows, it supports full traceability per ISO/IEC 17025:2017 clause 7.7 (sampling and sample handling) and facilitates automated calibration verification through periodic vacuum decay testing logged in Excel-compatible CSV format.
Applications
- Environmental analysis: extraction of PAHs, pesticides, pharmaceutical residues, and PFAS from surface water, wastewater, and soil leachates
- Clinical toxicology: cleanup of blood, serum, and urine prior to LC-MS/MS quantification of opioids, benzodiazepines, and stimulants
- Food safety testing: isolation of mycotoxins (aflatoxin B1, ochratoxin A), veterinary drug residues (fluoroquinolones, sulfonamides), and pesticide multiresidues
- Pharmaceutical QC: removal of excipients and degradation products from tablet dissolution media prior to HPLC assay
- Forensic chemistry: concentration and desalting of seized drug exhibits for GC-MS confirmation
FAQ
Does the QSE-12 require a dedicated vacuum pump?
Yes—a diaphragm or rotary vane vacuum pump capable of sustaining ≥85 kPa vacuum is required; recommended ultimate pressure ≤5 kPa for optimal flow consistency.
Can the system be sterilized for microbiological applications?
The glass manifold and UHMW-PE tray are autoclavable at 121 °C for 20 minutes; however, elastomeric seals and vacuum tubing must be replaced post-sterilization.
Is method validation support available?
Comprehensive IQ/OQ documentation templates—including pressure decay test procedures, channel uniformity verification, and sorbent retention capacity assessment—are provided with each instrument shipment.
What maintenance intervals are recommended?
Vacuum hose inspection every 6 months; glass manifold visual crack check before each use; UHMW-PE tray cleaning with isopropanol after exposure to protein-rich or viscous matrices.
Does the QSE-12 meet regulatory requirements for GMP environments?
When operated within a controlled environment and documented per internal SOPs, the system satisfies Annex 11 (EU GMP) and FDA guidance on equipment qualification for sample preparation stages preceding final assay.
