Cole-Parmer Avantor Dual-Channel Touchscreen Syringe Pump Model MFLA74905-50

Overview

The Cole-Parmer Avantor Dual-Channel Touchscreen Syringe Pump (Model MFLA74905-50) is an engineered precision fluid delivery system designed for laboratory-scale applications requiring high-resolution volumetric control and long-term operational stability. Based on stepper-motor-driven linear actuation, this pump delivers programmable, bidirectional fluid displacement via two independent syringe channels—enabling synchronized or asynchronous injection, withdrawal, or push-pull operation depending on configuration. Its core architecture adheres to fundamental principles of positive displacement pumping, where volumetric output is directly proportional to syringe plunger displacement and calibrated barrel geometry. This deterministic relationship ensures traceable flow performance across the full dynamic range—from femtoliter-per-minute microinfusion in single-cell electrophysiology to milliliter-per-minute reagent delivery in automated assay platforms. The pump meets essential mechanical and electrical safety requirements per UL 61010-1 and IEC 61010-1, and its design supports integration into GLP-compliant workflows through audit-ready parameter logging and hardware-level flow verification.

Key Features

• Intuitive 5-inch capacitive touchscreen interface with real-time flow visualization, programmable profiles, and one-touch recall of up to 40 stored methods (MFLA74905-54 variant)
• Dual-channel independent control supporting simultaneous or sequential operation—configurable for injection-only (MFLA74905-50), injection/withdrawal (MFLA74905-52), or true push-pull dual-syringe mode (MFLA74905-56)
• Ultra-wide flow range: 5 pL/min to 200 mL/min, achieved via motor step resolution optimization and selectable syringe diameters (0.5 µL–140 mL capacity)
• High-precision linear actuator delivering 75 lbs (340 N) maximum thrust force with ±0.355% volumetric accuracy and ±0.05% repeatability under ISO 8536-4 test conditions
• Modular mounting design: pump body rotates 90° for vertical or horizontal orientation; touchscreen auto-orients to maintain ergonomic visibility
• Industrial-grade metal enclosure with EMI-shielded electronics and vibration-damping mounts for stable operation in shared instrumentation environments
• Multi-protocol connectivity: RS-232, RS-485 (daisy-chain capable for up to 99 units), USB 2.0, and 15-pin D-sub analog/digital I/O for external trigger synchronization

Sample Compatibility & Compliance

The pump accommodates standard Luer-lock and Luer-slip syringes fabricated from borosilicate glass, polypropylene, polyethylene, or stainless steel—ensuring chemical compatibility with aqueous buffers, organic solvents, and viscous polymer solutions (viscosity range: ≤10,000 cP). Syringe calibration is performed using NIST-traceable reference standards per ASTM D341 viscosity-temperature correlation guidelines. Device firmware implements internal self-diagnostic routines prior to each run cycle, verifying motor torque response, encoder feedback integrity, and pressure-limit threshold compliance. All operational parameters—including flow rate, target volume, elapsed time, and error codes—are timestamped and logged in non-volatile memory, satisfying FDA 21 CFR Part 11 requirements for electronic records when paired with validated third-party software.

Software & Data Management

Local control is fully managed via the embedded touchscreen UI, eliminating dependency on external PCs. For networked deployment, optional Cole-Parmer PumpControl™ software (Windows/macOS) enables remote configuration, multi-pump coordination, real-time telemetry streaming, and CSV-exportable log files with metadata tagging (operator ID, method name, instrument serial number). Audit trails include user login/logout events, parameter modification timestamps, and execution status flags (e.g., “completed”, “aborted”, “overpressure fault”). Data export formats conform to MIAME-compliant annotation standards, facilitating integration with LIMS platforms such as LabVantage or Thermo Fisher SampleManager.

Applications

• Microfluidic device priming and continuous perfusion in organ-on-chip systems
• Controlled reagent addition in kinetic ELISA, PCR master mix preparation, and HPLC mobile phase blending
• Electrophysiology patch-clamp experiments requiring sub-nanoliter bolus delivery
• Chromatography column equilibration and gradient formation with dual-solvent precision
• Automated sample dilution series generation for calibration curve construction (ISO/IEC 17025)
• In situ polymerization initiation via metered co-injection of monomer and initiator solutions

FAQ

What syringe sizes are supported?
Syringes ranging from 0.5 µL micro-volume glass barrels to 140 mL industrial plastic reservoirs are mechanically and firmware-compatible.
Does the pump support bidirectional flow on both channels simultaneously?
Yes—models MFLA74905-52, -54, -56, and -58 support independent forward/reverse actuation per channel, enabling true push-pull operation with programmable phase offsets.
Is regulatory documentation available for GMP environments?
Avantor provides a Device Master Record (DMR), Installation Qualification (IQ) protocol templates, and Factory Acceptance Test (FAT) reports upon request.
How is flow accuracy verified during routine use?
Users may perform in-house verification using gravimetric measurement per USP <1058> Analytical Instrument Qualification, with certified analytical balances and temperature-controlled environmental chambers.
Can the pump be integrated into a SCADA or PLC-controlled lab automation system?
Yes—the RS-485 Modbus RTU interface supports register-mapped command sets for start/stop, flow setpoint updates, and status polling at 100 ms intervals.