Masterflex B/T Programmable Peristaltic Pump Model 77111-47

Overview

The Masterflex B/T Programmable Peristaltic Pump Model 77111-47 is an industrial-grade, microprocessor-controlled peristaltic pump engineered for high-precision fluid handling in regulated laboratory, pilot-scale bioprocessing, and quality control environments. Based on the positive displacement principle of peristalsis—where rollers compress a flexible tubing against a curved housing to generate flow—the system delivers repeatable, non-invasive, and contamination-free transfer without exposing fluids to mechanical seals or valves. Its modular architecture separates the motor-driven pump head from the digital controller via a 1.8 m shielded cable, enabling remote installation in fume hoods, biosafety cabinets, or integrated process skids while maintaining full operational visibility and control. Designed for compatibility with a wide range of chemically resistant tubing—including Tygon® LFL, platinum-cured silicone, and enhanced biopharmaceutical-grade elastomers—the pump supports continuous operation across viscosities up to 10,000 cP and accommodates tubing bore diameters from 0.5 mm to 6.4 mm.

Key Features

• Independent controller-pump head configuration with 1.8 m interconnect cable for spatial flexibility and operator safety
• Backlit LED display showing real-time parameters: rotational speed (rpm), volumetric flow rate (mL/min), cumulative dispensed volume (L), and remaining/elapsed repeat cycles
• Bi-directional operation with programmable pre- and post-run rinse sequences to minimize carryover in sequential dosing applications
• Keyboard lock function prevents accidental parameter changes during unattended operation
• User-stored calibration offsets for up to one set of tubing dimensions—automatically applied to maintain accuracy across different tube IDs and wall thicknesses
• Programmable dispensing mode: single-volume delivery (0.1–999 L, 0.1 L increments) with configurable repeat count (1–99 cycles), each cycle supporting volumes from 100 mL to 1000 L
• Analog and digital interface support: 0–20 mA, 4–20 mA, 0–10 V DC, and TTL pulse inputs for integration into PLC-based or SCADA-controlled systems
• IP56-rated enclosure—dust-protected and resistant to low-pressure water jets—enabling cleaning with aqueous solutions between runs without disassembly
• Integrated safety interlock: motor power is cut immediately upon opening the pump head cover, meeting IEC 61000-6-2 and ISO 13857 requirements for accessible moving parts

Sample Compatibility & Compliance

The Model 77111-47 is compatible with all Masterflex-certified peristaltic tubing, including standard Tygon LFL (77111-47标配), platinum-cured silicone (77300-32), bio-platinum silicone, and reinforced biopharmaceutical tubing—each selected for compliance with USP Class VI, FDA 21 CFR Part 177, and EU Regulation EC 1935/2004. The pump’s design supports Good Manufacturing Practice (GMP) workflows through traceable calibration records, audit-ready parameter logging (when paired with optional data acquisition modules), and compatibility with electronic batch record (EBR) systems. Its CE and cULus certifications confirm conformity with EN 61000-6-3 (EMC), EN 61000-6-2 (immunity), and UL 61010-1 for laboratory equipment safety. ISO 9001:2000 certification applies to the manufacturing and quality assurance processes at the U.S.-based facility.

Software & Data Management

While the 77111-47 operates as a standalone instrument with embedded firmware, it supports external data capture via its analog/digital I/O ports. When interfaced with a host PC running LabVIEW™, MATLAB®, or custom Python-based acquisition scripts (using RS-232 or USB-to-serial adapters), users can log time-stamped flow events, speed profiles, and dispense cycle completion signals. For regulated environments requiring ALCOA+ data integrity, optional Masterflex DataLink software (sold separately) provides 21 CFR Part 11-compliant user access control, electronic signatures, and immutable audit trails for all parameter changes and run histories. All stored calibrations are retained in non-volatile memory—even after power loss—and persist across firmware updates.

Applications

• Automated reagent dispensing in clinical chemistry analyzers and ELISA workstations
• Continuous feed of cell culture media or harvest streams in upstream bioprocessing
• Accurate metering of high-viscosity polymer solutions, slurries, or fermentation broths in R&D labs
• In-line sampling and dilution in environmental water analysis (e.g., EPA Method 200.7, 200.8)
• Buffer exchange and gradient formation in HPLC and FPLC auxiliary systems
• Pharmaceutical formulation development where tubing contact avoids metal leaching or catalytic degradation
• Quality control testing of viscosity standards, suspensions, and emulsions per ASTM D1200 and ISO 2555

FAQ

What tubing sizes are supported, and how does the pump auto-scale flow calculations?
The pump accepts Masterflex tubing with inner diameters from 0.5 mm to 6.4 mm. Upon entering tubing dimensions (ID, OD, wall thickness), the controller applies a pre-characterized flow coefficient derived from gravimetric calibration data—ensuring accurate mL/min output without manual conversion tables.
Can this pump be integrated into a GMP-compliant manufacturing line?
Yes—when used with validated tubing sets, calibrated against NIST-traceable flow standards, and operated with Part 11-compliant software, the system meets core requirements for automated liquid handling in pharmaceutical production under Annex 11 and ICH Q5C guidelines.
Is the 77111-47 suitable for sterile applications?
It is not inherently sterile but supports aseptic operation when paired with gamma-sterilizable platinum-cured silicone tubing and installed in ISO Class 5–7 environments; tubing replacement must follow SOPs aligned with ISO 14644-1.
How is flow accuracy maintained over extended operation?
Flow accuracy (±0.5%) is sustained through temperature-compensated motor control, roller wear compensation algorithms, and periodic recalibration using the built-in “tare” function with certified volumetric flasks.
What maintenance intervals are recommended?
Roller assemblies require inspection every 2,000 operating hours; tubing replacement frequency depends on chemical exposure and pressure—typically 500–2,000 hours for Tygon LFL and 1,000–3,000 hours for platinum silicone under moderate conditions.