METTLER TOLEDO MA204E Advanced Analytical Balance

Overview

The METTLER TOLEDO MA204E is a high-performance analytical balance engineered for precision mass measurement in regulated and routine laboratory environments. Operating on electromagnetic force compensation (EMFC) principle, it delivers traceable, reproducible results at a readability of 0.1 mg across its 220 g maximum capacity. Designed as a direct successor to the ME204 series, the MA204E maintains full backward compatibility with existing METTLER TOLEDO accessories and software ecosystems while incorporating enhanced mechanical robustness, improved thermal stability, and streamlined user interaction. Its core architecture—featuring a rigid metal frame, reinforced housing, and overload protection rated to 100 kg—ensures long-term metrological integrity under demanding daily use. The balance meets fundamental requirements of ISO/IEC 17025, USP , and ASTM E898 for analytical weighing, supporting GLP- and GMP-aligned workflows through built-in time/date stamping and audit-ready calibration records.

Key Features

• Electromagnetic force compensation (EMFC) transducer system for high linearity and minimal drift
• Internal calibration function with automatic temperature-triggered recalibration (AutoCal™)
• Backlit monochrome LCD display with intuitive icon-driven interface and adjustable contrast
• Metal base and PBT-reinforced metal enclosure for mechanical stability and chemical resistance
• Front-access leveling feet with visual bubble indicator for rapid instrument setup
• 10 pre-installed weighing applications: parts counting, percentage weighing, density determination, formulation, statistics, checkweighing, animal weighing, totalization, net/gross/tare, and user-defined custom modes
• USB-A and RS232 interfaces for seamless integration with LIMS, ELN, and data acquisition systems
• Smooth, rounded edges and non-porous surfaces for simplified cleaning and contamination control
• Stabilization time of ≤2 seconds under standard ambient conditions (20–25 °C, <60% RH)

Sample Compatibility & Compliance

The MA204E accommodates a broad range of sample types—including powders, granules, liquids in tared vessels, and small solid components—within its 90 mm diameter stainless steel weighing pan. Its design conforms to ISO 9001 manufacturing standards and supports compliance with regulatory frameworks including FDA 21 CFR Part 11 (when used with METTLER TOLEDO LabX® software), EU Annex 11, and WHO TRS 992 Annex 4. The balance’s internal calibration routine adheres to ISO 17025 clause 6.5.2 and satisfies USP minimum weight validation criteria, with a typical minimum weighable quantity of 0.16 g (k = 2, assuming 0.1% required accuracy). All calibration events—including external verification using Class E2 or better weights—are logged with timestamp, operator ID (if configured), and environmental metadata.

Software & Data Management

While the MA204E operates autonomously via its onboard interface, it is fully compatible with METTLER TOLEDO’s LabX® standalone software for advanced data handling, electronic signature support, and automated report generation. When connected via USB or RS232, the balance transmits raw weight values, timestamps, calibration status, and error codes in ASCII format—enabling direct import into Excel, MATLAB, or validated enterprise systems. Audit trail functionality (via LabX) provides immutable records of all critical events: weighings, calibrations, parameter changes, and user logins—fully compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).

Applications

• Quantitative preparation of reference standards and assay stock solutions in pharmaceutical QC labs
• Weighing of active pharmaceutical ingredients (APIs) and excipients per ICH Q5C guidelines
• Gravimetric analysis in academic and industrial chemistry laboratories
• Formulation development requiring high-resolution mass tracking across multiple components
• Environmental testing labs performing filter weighing for particulate matter (PM₂.₅/PM₁₀) analysis
• Materials science research involving precise powder dosing for composite synthesis
• Food safety testing where USP minimum weight thresholds must be verified prior to assay

FAQ

What is the difference between the MA204E and the legacy ME204 model?
The MA204E replaces the ME204 with updated firmware, enhanced thermal compensation algorithms, and improved mechanical damping—resulting in faster stabilization and reduced sensitivity to air currents.
Does the MA204E support internal calibration without external weights?
Yes. It features an integrated motorized calibration mass and AutoCal™ technology that initiates internal calibration automatically based on time intervals or temperature fluctuations.
Is the MA204E suitable for ISO/IEC 17025 accredited testing laboratories?
Yes—provided calibration is performed using traceable standards, environmental conditions are monitored, and uncertainty budgets are documented per ISO/IEC 17025:2017 clause 7.6.2.
Can the balance be connected to a networked LIMS system?
Direct Ethernet connectivity is not built-in; however, USB-to-Ethernet or RS232-to-serial-server gateways enable secure integration with networked LIMS when deployed with LabX or third-party middleware.
What is the recommended recalibration frequency for routine use?
Per USP , recalibration should occur before each sequence of critical weighings and after any event affecting performance (e.g., relocation, temperature shift >2 °C, or mechanical shock); many labs implement scheduled recalibration every 2–4 hours during continuous operation.