PreFluid F1-SWF350-PF246 High-Precision Servo-Driven Peristaltic Dispensing Pump
| Brand | PreFluid |
|---|---|
| Origin | Jiangsu, China |
| Model | F1-SWF350-PF246 |
| Speed Range | 1–350 rpm |
| Speed Resolution | 1 rpm |
| Operating Angle Range | 180–36000° |
| Angle Resolution | 1° |
| Power Supply | AC 220 V ±10%, 50/60 Hz |
| Ambient Temperature | 0–50 °C |
| Relative Humidity | <80% |
| Dispensing Accuracy | ±1% (at 2 mL volume with 2.4×2.4 mm tubing) |
Overview
The PreFluid F1-SWF350-PF246 is a high-precision, servo-controlled peristaltic dispensing pump engineered for repeatable, low-shear liquid handling in regulated pharmaceutical and diagnostic manufacturing environments. Unlike conventional stepper-motor-driven peristaltic systems, this model employs a compact, high-torque servo motor coupled with closed-loop angular position feedback—enabling precise control over rotational displacement (180–36000°), speed (1–350 rpm), and acceleration profiles. Its operation relies on the fundamental principle of peristalsis: two offset rollers compress a flexible elastomeric tube against a rigid curved housing, generating positive displacement without fluid contact with moving parts. This design ensures sterility maintenance, eliminates risk of cross-contamination, and supports aseptic processing in isolators or laminar flow hoods. The pump is specifically optimized for volumetric dispensing tasks requiring tight tolerance adherence—such as filling vials, syringes, or microtiter plates—with validated repeatability across batch runs.
Key Features
- Stainless steel pump head (AISI 316L compliant) with smooth, crevice-free surface finish—designed for clean-in-place (CIP) compatibility and rapid sterilization via vaporized hydrogen peroxide (VHP) or autoclaving.
- Dual-roller staggered geometry ensures continuous occlusion overlap, minimizing pulsation and delivering stable flow rates with coefficient of variation (CV) <0.8% under constant-speed operation.
- Vertical-mount configuration with integrated linkage mechanism between top pressure block and pump body—enabling single-hand tubing replacement without tooling or realignment.
- Pre-load friction compensation system dynamically adjusts roller compression force to extend tubing service life by up to 40% compared to fixed-pressure designs.
- Modular architecture: drive unit, pump head, and HMI are physically and electrically decoupled—allowing independent installation inside isolators, filling lines, or custom OEM equipment enclosures.
- Embedded control interface supports direct integration into third-party PLCs or SCADA systems via digital I/O (start/stop, no-bottle detection, fault signaling) and optional RS-485/Modbus RTU communication.
Sample Compatibility & Compliance
The F1-SWF350-PF246 accommodates standard biocompatible tubing sizes including 2.4×2.4 mm (ID×OD), 3.2×5.0 mm, and 4.8×8.0 mm—compatible with Santoprene®, PharMed® BPT, and C-Flex® materials certified to USP Class VI and ISO 10993-5. Its mechanical design conforms to ISO 13485:2016 requirements for medical device manufacturing equipment, and its operational parameters support validation protocols aligned with FDA 21 CFR Part 11 (when paired with audit-trail-enabled software), EU Annex 1 (aseptic processing), and ASTM D7219–17 (peristaltic pump performance testing). All electrical components meet CE marking requirements per EN 61000-6-2 (immunity) and EN 61000-6-4 (emissions).
Software & Data Management
The integrated Siemens SIMATIC HMI panel provides local parameter configuration—including speed setpoint, dispensing angle, ramp-up/down time, and batch count—and stores up to 100 user-defined recipes with timestamped execution logs. Optional Ethernet/IP or PROFINET connectivity enables centralized monitoring through MES platforms. When deployed in GxP environments, the system supports electronic record integrity via configurable audit trails, user-level access controls (admin/operator), and exportable CSV-formatted dispensing reports—including volume per cycle, total dispensed volume, and deviation alerts triggered by out-of-spec angle or speed drift (>±2 rpm from setpoint over 5 s). Firmware updates are performed via secure USB key with SHA-256 signature verification.
Applications
- Parenteral drug manufacturing: Accurate filling of liquid injectables (e.g., monoclonal antibodies, vaccines) into Type I glass vials at volumes ranging from 0.5 mL to 10 mL.
- In vitro diagnostics (IVD): Precise metering of reagent kits for ELISA, PCR master mixes, and lateral flow assay buffers—minimizing lot-to-lot variability.
- Lyophilized product preparation: Controlled delivery of formulation solutions into stoppered vials prior to freeze-drying, where shear-sensitive proteins require gentle pumping action.
- Cell therapy workflows: Aseptic transfer of cell suspensions and cryopreservation media into cryovials using gamma-sterilized tubing assemblies.
- Contract development and manufacturing organizations (CDMOs): Flexible platform for tech transfer across multiple fill-finish lines due to standardized mounting interfaces and scalable control architecture.
FAQ
What tubing sizes are officially validated for use with the PF246 pump head?
The PF246 pump head is validated for 2.4×2.4 mm, 3.2×5.0 mm, and 4.8×8.0 mm inner/outer diameter tubing—provided the material meets USP Class VI and ISO 10993-5 biocompatibility standards.
Can the pump be operated remotely via PLC without the touch screen?
Yes—the drive unit accepts discrete 24 VDC start/stop signals and provides isolated status outputs (e.g., running, fault, end-of-cycle); all critical motion parameters can be set via analog voltage (0–10 V) or Modbus RTU commands.
Is angle-based dispensing supported for non-continuous dosing applications?
Yes—each dispensing event is defined by programmable angular displacement (minimum increment: 1°), enabling precise drop-wise or multi-step aliquoting independent of time-based duration.
How is calibration traceability maintained during routine operation?
Calibration certificates for speed and angular position are issued per ISO/IEC 17025-accredited laboratory procedures; field verification is performed using calibrated optical encoders and gravimetric weighing per USP <1058> Analytical Instrument Qualification guidelines.
Does the system support GMP-compliant electronic signatures?
When integrated with validated MES or LIMS software, the pump’s event log exports support 21 CFR Part 11-compliant digital signature workflows—including role-based authentication and immutable record archiving.
