METTLER TOLEDO MX105 Analytical Balance

Overview

The METTLER TOLEDO MX105 Analytical Balance is a high-precision laboratory instrument engineered for demanding quantitative analysis in regulated and research-intensive environments. Operating on electromagnetic force compensation (EMFC) principle, the MX105 delivers exceptional repeatability and linearity across its full capacity range of 105 g with 0.01 mg readability. Its core measurement architecture integrates a temperature-compensated monolithic sensor and advanced digital filtering algorithms to minimize environmental drift—critical for trace-level mass determination in pharmaceutical development, reference standard preparation, and quality control laboratories. Designed for seamless integration into modern digital lab workflows, the MX105 serves as both a standalone precision weighing station and a validated node within automated analytical systems.

Key Features

• SmartPan Technology: A patented asymmetric weighing pan design that actively dampens air currents and mechanical vibrations, reducing stabilization time to ≤2 seconds even on non-isolated benchtops—enabling rapid sequential weighing without compromising accuracy.
• FACT (Fully Automatic Calibration Technology): Dual internal calibration masses trigger temperature-activated recalibration, ensuring traceable accuracy across ambient fluctuations from 10 °C to 30 °C without manual intervention.
• ErgoDoor Draft Shield: Motorized, height-adjustable sliding doors with soft-stop mechanism reduce operator fatigue during high-frequency weighing tasks while maintaining optimal airflow control around the weighing chamber.
• StatusLight Visual Feedback System: A three-color LED ring at the front panel provides real-time status indication—green (ready), yellow (calibrating or warning), red (error or overload)—eliminating ambiguous display interpretations.
• GxP-Ready Architecture: Supports user-level access control, electronic signatures, and audit trail generation when connected to METTLER TOLEDO LabX software—meeting requirements for GLP, GMP, and ISO/IEC 17025 documentation integrity.

Sample Compatibility & Compliance

The MX105 accommodates standard 90 mm diameter weighing vessels—including glass vials, aluminum pans, and ceramic crucibles—while maintaining optimal sensitivity across diverse sample densities and electrostatic profiles. Its draft shield meets ISO 17025 Annex A.3 recommendations for environmental isolation, and the balance’s mechanical design conforms to OIML R 76 Class I metrological requirements for analytical instruments. All firmware and communication protocols are validated against FDA 21 CFR Part 11 data integrity criteria when deployed with LabX or third-party LIMS via certified drivers. Routine performance verification (RPV) templates are preloaded per USP and ASTM E898 guidelines, enabling labs to define custom tolerance limits and auto-schedule internal checks based on usage frequency or time intervals.

Software & Data Management

The MX105 natively supports bidirectional data exchange via RS232, USB HID, and optional Ethernet interfaces. When paired with LabX laboratory software, it enables centralized method management, role-based permissions, and fully compliant electronic records—including timestamped weight values, operator IDs, environmental metadata (temperature/humidity if external sensors are linked), and calibration history. All data exports are generated in CSV, PDF, or XML formats with embedded digital signatures, satisfying ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate). The balance also supports direct printing to GLP-compliant thermal printers with customizable report headers and footer footers containing instrument ID, calibration due date, and QA approval fields.

Applications

• Pharmaceutical: Active pharmaceutical ingredient (API) assay, dissolution testing sample preparation, and reference standard weighing per ICH Q5C stability protocols.
• Academic Research: Nanomaterial mass quantification, catalyst loading in heterogeneous catalysis studies, and gravimetric sorption analysis.
• Chemical Manufacturing: Raw material release testing, batch record documentation, and stoichiometric reagent dispensing for synthesis scale-up.
• Food & Agriculture: Nutrient content validation (e.g., ash, moisture, protein assays), pesticide residue standard preparation, and certified reference material certification.
• Environmental Labs: Filter weighing for PM2.5/PM10 particulate matter analysis, soil organic carbon determination, and heavy metal recovery efficiency calculations.

FAQ

What is the maximum capacity and readability of the MX105 Analytical Balance?
The MX105 offers a maximum capacity of 105 g with 0.01 mg readability under standard operating conditions (20 °C ±1 °C, 45–60% RH, vibration-free environment).
Does the MX105 support internal calibration with temperature compensation?
Yes—it features FACT technology with two integrated calibration weights and a built-in temperature sensor that triggers automatic recalibration when drift exceeds preset thresholds.
Can the MX105 be integrated into a LIMS or ELN system?
Yes—via standardized communication protocols (RS232, USB, Ethernet) and certified LabX drivers, enabling secure, audit-trail-enabled data transfer to enterprise laboratory informatics platforms.
Is the MX105 compliant with FDA 21 CFR Part 11 requirements?
The hardware and firmware meet technical prerequisites; full compliance requires configuration with LabX software, proper user training, and documented SOPs for electronic signature implementation.
How does SmartPan improve weighing performance in non-ideal lab environments?
SmartPan’s asymmetric geometry disrupts resonant air eddies and attenuates low-frequency floor vibrations, allowing stable readings within 2 seconds—even on shared lab benches without active damping tables.