Acchrom-Tech HPMS-TQ Triple Quadrupole Liquid Chromatography Mass Spectrometer
| Brand | Acchrom-Tech |
|---|---|
| Origin | Liaoning, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Instrument Type | Tandem Quadrupole (QqQ) |
| Model | HPMS-TQ |
| Application Scope | General-purpose LC-MS/MS analysis |
| Compliance | Designed for GLP/GMP-aligned laboratories |
| Software | Fully integrated acquisition and quantitation platform with audit trail capability |
Overview
The Acchrom-Tech HPMS-TQ is a purpose-built triple quadrupole liquid chromatography mass spectrometer (LC-MS/MS) engineered for robust, high-throughput quantitative analysis in regulated and research environments. Operating on the well-established tandem quadrupole (QqQ) principle—where Q1 performs precursor ion selection, q2 serves as a collision cell for controlled fragmentation via collision-induced dissociation (CID), and Q3 conducts product ion detection—the system delivers exceptional selectivity, sensitivity, and reproducibility in multiple reaction monitoring (MRM) mode. Its architecture integrates a high-pressure liquid chromatography front-end with a vacuum-stable ion optics path, optimized RF/DC voltage control, and thermally stabilized detector electronics. The HPMS-TQ is designed to meet the analytical rigor required in pharmaceutical impurity profiling, clinical toxicology, food safety residue screening, environmental contaminant quantification, and biomarker validation workflows.
Key Features
- Triple quadrupole mass analyzer with independently tunable RF/DC parameters for Q1 and Q3, enabling precise mass filtering across m/z 5–2,000 Da
- Dual-mode electrospray ionization (ESI) source with polarity-switching capability and real-time source parameter optimization
- Optimized curtain gas and orifice interface design—minimizing matrix-induced signal suppression and reducing source contamination frequency by up to 40% compared to conventional atmospheric pressure interfaces
- Collision cell featuring nitrogen-based CID with adjustable collision energy (0–60 eV) and low-energy resolution tuning for optimal fragment ion yield
- High-dynamic-range electron multiplier detector with extended linear response (>5 orders of magnitude) and <1% relative standard deviation (RSD) for replicate MRM transitions
- Modular vacuum system with dual-stage turbomolecular pumps and active pressure regulation for stable operation under variable ambient conditions
Sample Compatibility & Compliance
The HPMS-TQ supports direct coupling to standard UHPLC and HPLC systems (including gradient-compatible 1,000 bar platforms), accommodating reversed-phase, HILIC, and ion-pairing chromatographic methods. It accepts aqueous/organic mobile phases containing common additives (e.g., formic acid, ammonium acetate, trifluoroacetic acid) without source degradation. All hardware and firmware components comply with IEC 61010-1 safety standards. Data acquisition and processing software conform to ALCOA+ principles and support 21 CFR Part 11-compliant user authentication, electronic signatures, and full audit trail logging—including method changes, calibration events, and raw data modifications. System suitability testing protocols align with USP , ASTM D7897, and ISO/IEC 17025 requirements for accredited testing laboratories.
Software & Data Management
The proprietary AcchromControl™ software provides unified control of LC gradients, MS acquisition parameters, and post-run processing. It includes built-in MRM method setup wizards, automatic peak integration with retention time alignment, isotopic correction algorithms, and customizable report templates compliant with LIMS export formats (e.g., CSV, XML, AnIML). Raw data files are stored in vendor-neutral .d format (compatible with open-source tools such as msConvert), while processed results support PDF/A-2 archival and Excel-based summary exports. Full traceability is maintained through hierarchical user roles, session-level lockout after inactivity, and encrypted database backups synchronized to network-attached storage.
Applications
The HPMS-TQ is validated for use in multi-residue pesticide analysis per EU SANTE/11312/2021 guidelines; small-molecule pharmacokinetic studies (plasma, urine, tissue homogenates); mycotoxin quantification in cereals using isotope dilution mass spectrometry (IDMS); steroid hormone profiling in clinical diagnostics; and PFAS compound screening in drinking water per EPA Method 1633. Its modular configuration allows seamless adaptation to emerging regulatory frameworks—including CLIA-certified assay development and FDA bioanalytical method validation (BMV) workflows.
FAQ
Is the HPMS-TQ compatible with third-party LC systems?
Yes—standardized analog/digital I/O ports and Ethernet-based API enable bidirectional communication with Agilent, Waters, Shimadzu, and Thermo UHPLC modules.
Does the system support scheduled maintenance alerts and predictive diagnostics?
Yes—embedded sensor telemetry monitors vacuum integrity, detector gain drift, and source temperature stability, triggering configurable notifications prior to performance deviation.
Can raw data be reprocessed with updated calibration curves or integration parameters?
Yes—full backward compatibility ensures all raw .d files retain complete spectral metadata, allowing retrospective reprocessing without loss of acquisition context.
What level of technical support is provided post-installation?
Acchrom-Tech offers on-site installation qualification (IQ), operational qualification (OQ), and preventive maintenance contracts with 4-hour remote response SLA and 72-hour on-site dispatch for critical failures.
