Agela SPE-M08 Positive-Pressure Multi-Channel Solid Phase Extraction System
| Brand | Agela |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model | SPE-M08 |
| Automation Level | Fully Automatic |
| Number of Channels | 8 |
| Extraction Format | Cartridge-Based SPE |
| Flow Control | Independent, adjustable flow per channel with individual on/off valve control |
| Sample Capacity | Up to 8 samples simultaneously |
| Sample Loading Volume | Up to 50 mL standard |
| Dual Gas Path Design | One path for precise liquid flow regulation, one dedicated to cartridge drying/dehydration |
Overview
The Agela SPE-M08 Positive-Pressure Multi-Channel Solid Phase Extraction System is an engineered solution for high-throughput, reproducible sample preparation in analytical laboratories. Designed around positive-pressure-driven elution—rather than traditional vacuum manifold systems—the SPE-M08 delivers superior control over fluid dynamics during conditioning, loading, washing, and elution steps. This architecture eliminates channel-to-channel vacuum imbalance, ensuring consistent residence time and solvent contact across all eight parallel SPE cartridges. The system operates on compressed gas (typically nitrogen or air), enabling precise, pulse-free flow delivery critical for method robustness in regulated environments such as environmental monitoring, food safety testing, and pharmaceutical QC labs.
Key Features
- Fully automated 8-channel architecture with independent pneumatic flow control per channel—each equipped with a dedicated precision pressure-regulating valve and on/off solenoid valve.
- Dual independent gas supply paths: one optimized for fine-tuned solvent flow regulation (0–100 kPa range, ±0.5 kPa repeatability), the other reserved exclusively for post-wash nitrogen purge and cartridge drying—minimizing residual water carryover into eluates.
- Modular column compatibility: accommodates standard 1 mL, 3 mL, 6 mL, and 12 mL SPE cartridges (e.g., C18, SCX, SAX, HLB, silica) as well as 47 mm diameter SPE membrane disks, supporting diverse analyte chemistries and matrix types.
- Scalable sample volume handling: standard configuration supports up to 50 mL per sample; when fitted with the optional large-volume loading accessory (including peristaltic pump module and 5-L reservoir interface), the system enables trace analyte enrichment from liter-scale aqueous matrices—ideal for EPA Method 525.3 (drinking water), ISO 17993 (wastewater), or EU 2020/2184 compliance workflows.
- Robust stainless-steel and PTFE-wetted fluid path construction ensures chemical resistance to organic solvents (acetonitrile, methanol, ethyl acetate), acidic/basic aqueous buffers, and aggressive cleaning agents—supporting extended operational lifetime and minimal cross-contamination risk.
Sample Compatibility & Compliance
The SPE-M08 is validated for use with a broad spectrum of sample matrices—including surface water, wastewater, plasma, urine, milk, fruit juice, and soil extracts—when paired with appropriate sorbent chemistries. Its design aligns with key regulatory guidance documents: it supports method development and validation per ICH Q2(R2), enables audit-ready operation under GLP and GMP frameworks, and facilitates 21 CFR Part 11–compliant data integrity when integrated with Agela’s optional SPE-Link software (with electronic signatures, user access controls, and immutable audit trails). All hardware components meet CE marking requirements for laboratory equipment (2014/30/EU EMC Directive and 2014/35/EU Low Voltage Directive).
Software & Data Management
While the base SPE-M08 operates via intuitive front-panel controls and analog pressure gauges, integration with Agela’s SPE-Link PC software (optional) unlocks full digital workflow management. SPE-Link provides method storage, real-time pressure/flow logging per channel, scheduled run initiation, and export of timestamped CSV reports compliant with LIMS ingestion protocols. All system events—including valve actuation, pressure setpoint changes, and run completion—are recorded with operator ID, date/time stamp, and device serial number—ensuring traceability required for ISO/IEC 17025 accreditation and FDA inspection readiness.
Applications
- Environmental analysis: extraction of pesticides, PAHs, pharmaceuticals, and PFAS from drinking water, groundwater, and municipal effluents per EPA 500-series and ISO 17993 protocols.
- Clinical toxicology: cleanup of biological fluids prior to LC-MS/MS quantification of drugs of abuse, opioids, and metabolites—reducing ion suppression and extending column life.
- Food safety: isolation of veterinary drug residues (e.g., sulfonamides, fluoroquinolones) and mycotoxins (aflatoxins, ochratoxin A) from complex food homogenates.
- Pharmaceutical R&D: desalting and buffer exchange of peptide synthesis crude mixtures or biologic intermediates prior to HPLC purification.
FAQ
Can the SPE-M08 be used with both reversed-phase and ion-exchange cartridges?
Yes—the system’s inert fluid path and programmable pressure profiles support all common SPE sorbent chemistries, including C18, C8, SCX, SAX, NH₂, and mixed-mode resins.
Is method transfer from vacuum-based SPE possible?
Yes—Agela provides application notes detailing equivalent flow rates, conditioning volumes, and drying times to ensure seamless transition while improving inter-run precision.
Does the system require external nitrogen supply?
It can operate with either clean, oil-free compressed air or nitrogen; typical inlet pressure requirement is 600–800 kPa with flow rate ≥20 L/min at peak demand.
How is maintenance performed on the pneumatic valves and regulators?
All critical pneumatic components are field-replaceable modular units with documented service intervals; no tools are required for routine filter replacement or valve calibration verification.
Is third-party software integration supported?
Yes—the system features RS-232 and USB virtual COM port interfaces, enabling direct communication with LabWare LIMS, Thermo Fisher Chromeleon, or Waters Empower via custom script or OPC UA middleware.
