Agilent 1290 Infinity III Ultra-High-Performance Liquid Chromatography System (Rental)
| Brand | Agilent Technologies |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | 1290 Infinity III |
| Pricing | Available Upon Request |
Overview
The Agilent 1290 Infinity III UHPLC system is an engineered platform for high-throughput, high-resolution liquid chromatographic analysis in regulated and research laboratories. Based on dual-pump gradient architecture and low-dispersion fluidic design, it operates under pressures up to 1300 bar and flow rates from 0.2 to 5 mL/min—enabling seamless method transfer between UHPLC and conventional HPLC configurations. Its core architecture minimizes extra-column band broadening through sub-10 µL gradient delay volume, ultra-low dwell volume, and nanoliter-scale injection precision. The system supports both analytical and preparative-scale separations while maintaining compliance with ICH Q2(R2), USP <621>, and ISO/IEC 17025 requirements for method validation and data integrity.
Key Features
- High-pressure capability: 1300 bar maximum operating pressure for sub-2 µm particle column utilization and rapid gradient elution
- Extended flow range: 0.2–5 mL/min accommodates narrow-bore, standard-bore, and semi-preparative columns
- Dual-needle autosampler: Enables parallel sample loading and injection, reducing cycle time by up to 40% versus single-needle systems
- Ultra-low carryover: <10 ppm residual after multi-stage wash protocols—validated with challenging analytes including chlorhexidine and highly retained basic compounds
- Intelligent solvent management: Real-time solvent level sensing with predictive consumption modeling and low-level alerts prevent run interruption and reanalysis
- Sample ID reader integration: Barcode-based vial recognition eliminates manual position entry and reduces operator error
- Thermal control precision: Column compartment maintains temperature from –20 °C to +110 °C with ±0.15 °C stability; accommodates up to eight columns with MCT option
- Modular detector compatibility: Fully supports DAD, fluorescence, RID, and mass spectrometry interfaces via standardized LC-MS coupling ports
Sample Compatibility & Compliance
The 1290 Infinity III is validated for use across pharmaceutical QC/QA, biopharmaceutical characterization, environmental testing, and food safety applications. It meets the hardware and software prerequisites for 21 CFR Part 11-compliant operation when paired with OpenLab CDS or MassHunter software—including electronic signatures, audit trail generation, and role-based access control. Column thermal management complies with ASTM E2681 for column oven performance verification. System suitability testing (SST) workflows are preconfigured per USP general chapters <621> and <1058>, supporting automated pass/fail evaluation of resolution, tailing factor, and RSD criteria.
Software & Data Management
Instrument control and data acquisition are managed via Agilent’s InfinityLab Instrument Control Framework (ICF), enabling bidirectional communication with third-party CDS platforms including Thermo Chromeleon, Waters Empower, and Shimadzu LabSolutions. OpenLab CDS provides full GLP/GMP support with secure user authentication, immutable audit trails, and electronic record retention aligned with ALCOA+ principles. Method transfer is accelerated using Intelligent System Emulation Technology (ISET), which models dwell volume, dispersion, and gradient delay characteristics of legacy Agilent or non-Agilent systems—allowing direct migration of HPLC methods without re-optimization. Data export conforms to AIA/ANDI standards for cross-platform spectral and chromatogram interchange.
Applications
This UHPLC platform delivers robust performance in small-molecule impurity profiling, peptide mapping, monoclonal antibody charge variant analysis, residual solvent quantification (ICH Q3C), and forced degradation studies. Its high-pressure tolerance enables use of superficially porous particle (SPP) and sub-2 µm fully porous columns for enhanced peak capacity and shortened analysis times. In environmental labs, it supports EPA Methods 8330B (PAHs), 8082A (PCBs), and 549.2 (pesticides) with improved sensitivity and reproducibility. For clinical research, the system supports LC-MS/MS bioanalysis of therapeutic drugs and metabolites under FDA Bioanalytical Method Validation Guidance.
FAQ
What rental options are available for the 1290 Infinity III system?
We offer short-term rental (1–6 months), rent-to-own (with credit toward purchase), and lease-to-own (title transfer upon final payment). All include installation, qualification documentation (IQ/OQ), and remote technical support.
Is method transfer supported from legacy Agilent or non-Agilent HPLC systems?
Yes—via Intelligent System Emulation Technology (ISET), which replicates system dwell volume, gradient delay, and dispersion profiles to ensure consistent retention time and peak shape across platforms.
Can the system be integrated into a laboratory with existing third-party CDS software?
Yes—through Agilent’s Instrument Control Framework (ICF), which provides certified drivers for Waters Empower, Thermo Chromeleon, and Shimadzu LabSolutions.
What is included in the standard rental package?
Binary or quaternary pump, multisampler, thermostatted column compartment, UV/Vis or DAD detector, OpenLab CDS software license, installation, operational qualification (OQ), and on-site training.
Does the rental include preventive maintenance and service coverage?
All rental agreements include comprehensive service coverage with 24/7 remote diagnostics, quarterly performance verification, and priority response for hardware-related incidents.
