Agilent 7200 Q-TOF GC/MS System (Refurbished)

Overview

The Agilent 7200 Q-TOF GC/MS System is a high-performance, refurbished gas chromatography–quadrupole time-of-flight mass spectrometry platform engineered for untargeted screening, structural elucidation, and quantitative confirmation in complex matrices. As the first GC-coupled Q-TOF system purpose-built by Agilent Technologies, it integrates a robust 7890B gas chromatograph, a 7693A autosampler, and the 7200 mass spectrometer — combining quadrupole mass filtering with orthogonal acceleration time-of-flight (oa-TOF) detection. This architecture delivers simultaneous high-resolution full-scan MS and MS/MS acquisition without sacrificing sensitivity or duty cycle. The system operates on the principle of mass-dependent ion time-of-flight measurement following pulsed orthogonal extraction, enabling sub-ppm mass accuracy ( 35,000 FWHM (at m/z 556), and linear dynamic range exceeding 5 orders of magnitude. Designed for laboratories requiring regulatory-compliant workflows, it supports both targeted and non-targeted analysis across environmental, food safety, forensic, and pharmaceutical applications.

Key Features

• Quadrupole–time-of-flight hybrid architecture with real-time MS and MS/MS switching in a single acquisition
• Dual-gain amplifier with dual analog-to-digital converters (ADCs) for extended dynamic range and simultaneous high- and low-abundance ion detection
• 4 GHz sampling ADC circuitry enabling 32 Gbit/s data throughput and sub-millisecond spectral acquisition rates
• Vacuum-insulated INVAR flight tube ensuring thermal stability and mass calibration reproducibility over 7-day continuous operation
• Hexapole collision cell optimized for efficient fragmentation and high-transmission MS/MS spectra
• Modular, vacuum-isolated ion source assembly — fully removable without venting the mass analyzer, reducing maintenance downtime
• Electron ionization (EI) and optional chemical ionization (CI) compatibility with standard Agilent source configurations

Sample Compatibility & Compliance

The Agilent 7200 Q-TOF GC/MS accommodates volatile and semi-volatile organic compounds across broad polarity ranges (e.g., pesticides, PAHs, PCBs, flavor compounds, residual solvents). It accepts standard 2 mL autosampler vials and interfaces seamlessly with Agilent’s inert-flow GC inlet systems (split/splitless, PTV, CPI). All refurbished units undergo full functional validation per Agilent’s Factory Acceptance Test (FAT) protocol, including mass calibration stability, peak shape assessment, signal-to-noise verification at trace levels (e.g., 1 pg µL⁻¹ chlorpyrifos), and retention time reproducibility (RSD < 0.15% over 10 injections). Systems are configured to meet GLP/GMP documentation requirements and support 21 CFR Part 11–compliant audit trails when deployed with Agilent MassHunter Workstation Software (v10.1 or later).

Software & Data Management

Data acquisition and processing are performed using Agilent MassHunter Qualitative and Quantitative Analysis software, supporting both centroided and profile-mode raw data handling. The platform enables automated deconvolution of co-eluting peaks, accurate mass database searching (NIST, Wiley, mzCloud), in silico fragmentation prediction (MassHunter Metabolite ID), and batch-processing workflows for large-scale sample sets. Raw files (.d format) are natively compatible with third-party tools including XCMS Online, MZmine 3, and Compound Discoverer. All refurbished systems ship with licensed, up-to-date software versions and include configuration files validated for routine QC standards (e.g., Agilent EPA 8270D mix, NIST SRM 1950). Data integrity is preserved through timestamped acquisition logs, electronic signatures, and configurable user access controls.

Applications

• Non-targeted metabolomics and exposomics profiling in biological fluids and tissues
• Residue monitoring in food and agricultural commodities (EU MRL compliance)
• Identification of unknown contaminants in environmental water and soil extracts
• Confirmation and quantification of banned substances in forensic toxicology
• Impurity profiling and degradation product characterization in pharmaceutical development
• High-confidence compound annotation in natural product discovery

FAQ

Is this a factory-refurbished unit or dealer-refurbished?
All Agilent 7200 Q-TOF systems are refurbished by Agilent-certified technicians following OEM service bulletins and include replacement of critical wear components (ion source parts, detector, turbomolecular pump bearings, GC consumables).
What warranty and service support is included?
Each system carries a 90-day comprehensive hardware warranty covering all mass spectrometer, GC, and autosampler modules. Extended service plans (1–3 years) with priority remote diagnostics and on-site engineer dispatch are available.
Can the system be upgraded to support GC×GC or additional ionization sources?
Yes — the 7890B GC chassis supports comprehensive modular expansion, including Agilent’s 2D GC interface and optional APCI or CI sources; upgrade paths are assessed during pre-delivery technical review.
Are original Agilent calibration standards and documentation provided?
Yes — each instrument ships with certified calibration kits (e.g., PFTBA, DFTPP), full FAT reports, maintenance history logs, and digital copies of user manuals and safety documentation.
Does the system comply with ISO/IEC 17025 method validation requirements?
The platform meets instrumental performance criteria outlined in ISO 17025:2017 Annex B for mass spectrometric methods; method-specific validation templates and IQ/OQ/PQ protocols are supplied upon request.