Agilent 7696A Sample Preparation Platform (Refurbished)

Overview

The Agilent 7696A Sample Preparation Platform is a modular, benchtop automation system engineered for high-precision offline sample conditioning prior to liquid chromatography (LC) or gas chromatography (GC) analysis. Unlike integrated autosamplers, the 7696A operates as a standalone workstation that executes gravimetrically controlled sample manipulation—leveraging a certified analytical balance integrated into its WeighStation module—to perform mass-based dilutions, internal standard addition, derivatization, and liquid–liquid extraction. This mass-directed approach satisfies the metrological requirements of ASTM D7097, EN 15510, and other regulatory methods where volumetric uncertainty must be minimized. Designed for laboratories transitioning from manual workflows to regulated, traceable sample preparation, the platform reduces operator-induced variability while maintaining full compatibility with existing LC/GC systems—including Agilent 1260/1290 Infinity II LC and 7890/8890 GC platforms.

Key Features

• Gravimetric dispensing via integrated WeighStation module, enabling mass-based quantitation with ≤0.1 mg resolution and traceable calibration
• Automated execution of multi-step protocols: dilution, spiking, reconstitution, micro-scale LLE, derivatization (with programmable heating up to 90 °C), and vortex mixing (300–2500 rpm)
• 150-position 2 mL vial capacity with barcode scanning support for unambiguous sample identification and chain-of-custody documentation
• Modular liquid handling tower with positive-displacement syringes and low-dead-volume tips, delivering ≤1% RSD for transfers ≥10 µL
• Enclosure-compatible design: fully operable inside fume hoods to mitigate analyst exposure to volatile solvents and hazardous reagents
• Easy SamplePrep software with drag-and-drop protocol builder, real-time status monitoring, and method locking for SOP compliance
• Audit-trail functionality compliant with FDA 21 CFR Part 11 requirements, including user authentication, electronic signatures, and immutable log files

Sample Compatibility & Compliance

The 7696A supports aqueous, organic, and mixed-phase matrices across environmental, pharmaceutical, food safety, and forensic applications. It accommodates standard 2 mL screw-thread or crimp-top vials (Agilent, Waters, Thermo Fisher), as well as custom tube formats via configurable rack adapters. All liquid handling operations are validated per ISO/IEC 17025 principles, and gravimetric workflows align with USP Analytical Instrument Qualification guidelines. The system meets GLP and GMP readiness criteria through configurable electronic records, version-controlled method storage, and automated report generation—including weight logs, transfer volumes, timestamps, and operator IDs.

Software & Data Management

Easy SamplePrep provides a Windows-based graphical interface with intuitive workflow mapping, parameter validation checks, and built-in error recovery logic. Protocols are stored in encrypted XML format with checksum verification. Data export supports CSV, PDF, and XML schemas compatible with LIMS integration (e.g., LabVantage, STARLIMS). Raw balance readings, tip wash cycles, and temperature ramp profiles are archived with time-stamped metadata. Optional IQ/OQ/PQ documentation packages are available for laboratory qualification under ISO 9001 or ISO/IEC 17025 frameworks.

Applications

• Environmental testing: EPA Method 525.3 (drinking water), 8270D (semivolatiles), and ISO 17993 (PAHs in soil) requiring precise spiking and dilution
• Pharmaceutical QC: Residual solvent analysis per ICH Q2(R2), extractables/leachables studies with internal standard normalization
• Food and beverage: Pesticide residue quantitation (EN 15662), mycotoxin derivatization (AOAC 2005.08), and fatty acid methyl ester (FAME) preparation
• Clinical toxicology: Urine drug screening with isotopically labeled internal standards and enzymatic hydrolysis steps

FAQ

Is the Agilent 7696A compatible with non-Agilent chromatography systems?
Yes—the platform operates independently of the downstream analyzer and delivers prepared samples in standard vial formats compatible with all major LC/GC autosamplers.
Does the refurbishment include recalibration of the WeighStation module?
Yes—each unit undergoes full balance recalibration using NIST-traceable weights, documented in the Certificate of Calibration provided with shipment.
Can the system be qualified for use in a regulated GxP environment?
Yes—SpectraLab provides optional IQ/OQ documentation kits, along with validation support services aligned with FDA, EMA, and PMDA expectations.
What maintenance is required during the 6-month warranty period?
No scheduled maintenance is required; however, we recommend quarterly tip washer cleaning and annual balance verification using certified reference masses.
Is remote software support available after purchase?
Yes—SpectraLab offers tiered technical support contracts, including remote desktop assistance, protocol troubleshooting, and method optimization consulting.