Agilent Certified Refurbished 1290 Infinity Liquid Chromatograph

Overview

The Agilent Certified Refurbished 1290 Infinity Liquid Chromatograph is a high-performance, ultra-high-pressure liquid chromatography (UHPLC) system engineered for maximum resolution, speed, and sensitivity in demanding analytical laboratories. Based on Agilent’s proven dual-piston positive displacement pump architecture and low-dispersion fluidic design, the system delivers exceptional gradient accuracy, retention time reproducibility, and baseline stability—critical for method transfer, regulatory compliance, and multi-laboratory harmonization. With a maximum operating pressure of 1200 bar, it supports sub-2-µm particle columns, narrow-bore and microbore configurations, and all common stationary phases—including C18, HILIC, ion-exchange, and chiral media—enabling seamless transition from conventional HPLC to RRLC and UHPLC workflows. As a certified refurbished unit, it undergoes Agilent’s rigorous factory-level refurbishment protocol, ensuring performance equivalence to new systems while delivering significant capital expenditure optimization.

Key Features

• 1200 bar maximum system pressure—compatible with all commercially available UHPLC columns and advanced packing materials (e.g., sub-2 µm, core-shell, porous graphitic carbon)
• Dual-piston, high-precision solvent delivery with active leak compensation and real-time pressure monitoring
• Low-volume, low-dead-volume flow path (< 10 µL total system dispersion) minimizing band broadening and maximizing peak capacity
• Thermostatted column compartment with ±0.1 °C temperature control (range: 5–80 °C) for retention time stability
• Variable-wavelength UV/Vis detector with 10 Hz data acquisition rate and < 0.0005 AU noise specification at 254 nm
• Integrated degasser with four-channel vacuum membrane technology and automatic self-purge function
• Agilent-certified refurbishment: full functional validation, replacement of all wear-prone components with genuine Agilent parts, firmware and software updated to latest stable release, and cosmetic restoration including front panel replacement

Sample Compatibility & Compliance

The 1290 Infinity LC accommodates a wide range of sample matrices—including pharmaceutical actives, biologics (mAbs, peptides), environmental extracts, food additives, and clinical biomarkers—without requiring hardware modification. Its modular architecture allows integration with Agilent 6100/6200/6400/6500 series mass spectrometers for LC/MS applications. All certified refurbished units are verified against Agilent’s internal Performance Qualification (PQ) test suite, which includes system suitability testing per USP , ISO 17025 traceable calibration, and pressure/flow accuracy verification per ASTM E2683. The system supports 21 CFR Part 11-compliant electronic records and signatures when operated with OpenLab CDS or MassHunter software under validated configurations. Audit trail functionality, user access controls, and electronic signature workflows are fully preserved post-refurbishment.

Software & Data Management

Certified refurbished 1290 Infinity systems ship with Agilent OpenLab CDS (ChemStation Edition or EZChrom Edition, depending on configuration) or MassHunter Workstation software, pre-installed and licensed for immediate deployment. All software versions are current at time of refurbishment and include built-in method validation templates, automated system suitability assessment, and report generation compliant with GLP, GMP, and ISO/IEC 17025 requirements. Data integrity safeguards—including immutable audit trails, role-based permissions, and secure backup/export protocols—are fully operational. Optional upgrades to OpenLab ECM (Enterprise Content Management) enable centralized instrument management, long-term data archiving, and cross-platform workflow orchestration across distributed lab environments.

Applications

• Pharmaceutical QC/QA: assay, impurity profiling, stability-indicating methods, and dissolution testing per ICH Q2(R2) guidelines
• Biopharmaceutical characterization: intact mass analysis, peptide mapping, glycan profiling, and charge variant separation
• Environmental analysis: pesticide residue screening, PFAS quantification, and PAH detection in soil/water matrices
• Clinical research: therapeutic drug monitoring (TDM), vitamin D metabolite quantification, and steroid hormone profiling
• Food & beverage safety: mycotoxin detection, adulterant screening, and nutritional labeling verification
• Academic & method development labs: high-throughput method scouting, column evaluation, and robustness testing

FAQ

What does “Agilent Certified Refurbished” mean?

It signifies that the instrument has been returned to Agilent’s authorized service center, disassembled, inspected, cleaned, and rebuilt using only genuine Agilent replacement parts. Each unit undergoes full functional testing, performance qualification, and software/firmware updates before issuance of a Certificate of Refurbishment.
Is the 1-year warranty identical to that of a new 1290 Infinity LC?

Yes—the warranty covers parts, labor, and on-site service (where applicable) under the same terms and conditions as Agilent’s standard new-instrument warranty.
Can this system be integrated with third-party mass spectrometers?

While optimized for Agilent MS detectors, the 1290 Infinity LC features industry-standard analog and digital I/O interfaces (e.g., TTL triggers, RS-232, Ethernet), enabling synchronization with select non-Agilent MS platforms via custom interface modules.
Are original accessories included?

All certified refurbished units include essential startup accessories: column couplers, frits, capillary tubing, solvent bottles, and system initialization kits. Optional accessories (e.g., autosampler vial trays, column ovens, or fraction collectors) are available separately.
Is remote diagnostics supported?

Yes—when connected to a secure network and configured with Agilent Remote Support (ARS), qualified Agilent engineers can perform preliminary diagnostics, log review, and firmware troubleshooting without onsite visits.