AIGIS Microfluidic Multi-Position Multiport HPLC/UHPLC Injection Valve
| Brand | AIGIS |
|---|---|
| Origin | Fujian, China |
| Manufacturer Type | OEM/ODM Producer |
| Regional Classification | Domestic (China) |
| Model | Microfluidic HPLC Valve |
| Pricing | Upon Request |
| Port Configurations | 4-, 6-, 8-, 10-, and 12-port configurations with dual-state switching (State 1 / State 2) |
Overview
The AIGIS Microfluidic Multi-Position Multiport HPLC/UHPLC Injection Valve is a precision-engineered fluidic control component designed for integration into high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC) systems. It operates on the principle of rotary or sliding-seal multiport valve actuation to enable deterministic, low-dead-volume routing of sample streams, mobile phase gradients, column switching paths, or standard calibration solutions. Unlike traditional solenoid-driven valves, this microfluidic valve series emphasizes mechanical stability, chemical inertness, and reproducible flow path geometry—critical for maintaining chromatographic integrity under UHPLC conditions (up to 1300 bar operating pressure). Its modular architecture supports seamless integration with both analytical-scale and preparative-scale LC platforms, including those compliant with ISO 17025-accredited laboratories and regulated environments requiring traceable method transfer.
Key Features
- Multi-configuration port options: Available in 4-, 6-, 8-, 10-, and 12-port variants, each supporting two discrete operational states (State 1 and State 2) for flexible flow path reconfiguration.
- Microfluidic-optimized internal geometry: Minimized internal volume (< 1.2 µL per port path), reduced carryover (< 0.05%), and symmetric flow distribution ensure high peak fidelity and retention time reproducibility across injections.
- Chemically resistant wetted materials: Standard construction includes PEEK, sapphire, and 316L stainless steel—validated for compatibility with aggressive solvents (e.g., THF, DCM, concentrated acids/bases) and pH ranges from 1–14.
- Actuation flexibility: Compatible with TTL-triggered stepper motor drivers or pneumatic actuators; supports both manual and automated system-level control via RS-485 or digital I/O interfaces.
- Leak-tight performance: Tested to 1500 bar static pressure with helium leak rate < 1×10⁻⁹ mbar·L/s; validated per ASTM F2096 bubble test methodology.
- Modular mounting interface: Standard 1/4″-28 UNF and M6 threaded ports; optional Swagelok®-compatible ferrule sets and zero-dead-volume union fittings available.
Sample Compatibility & Compliance
This valve accommodates aqueous, organic, and mixed-phase samples without degradation of sealing integrity or flow path accuracy. It is routinely deployed in applications involving biological matrices (serum, plasma, cell lysates), small-molecule pharmaceuticals, polymer additives, and environmental extracts. The device complies with general requirements outlined in ISO 8573-1 (compressed air purity for actuation), ISO 15195 (reference measurement procedures for clinical analyzers), and supports alignment with GLP/GMP documentation workflows. While not individually certified to FDA 21 CFR Part 11, its deterministic state-switching behavior, audit-ready position logging capability (when paired with compatible controller firmware), and repeatable mechanical hysteresis (< ±0.3° angular deviation) facilitate validation under laboratory quality management systems aligned with USP and ICH Q2(R2).
Software & Data Management
The valve does not include embedded firmware but is fully interoperable with industry-standard chromatography data systems (CDS), including Thermo Chromeleon™, Waters Empower™, Agilent OpenLab CDS, and Shimadzu LabSolutions™. When integrated with programmable logic controllers (PLCs) or custom LabVIEW™/Python-based instrument control layers, it supports synchronized timing triggers for injection event logging, sequence-defined port mapping, and real-time position feedback via auxiliary encoder outputs. All switching events can be timestamped and exported as CSV metadata alongside chromatographic runs—enabling full traceability required for regulatory submissions and internal method verification.
Applications
- Online solid-phase extraction (SPE-LC) with multi-column parallelization
- Heart-cutting and comprehensive 2D-LC (LC×LC) modulation interfaces
- Automated standard addition and internal standard dilution protocols
- Method development screening using sequential column or mobile phase selection
- High-throughput bioanalytical assay support in QC/QA labs (e.g., PK/PD studies)
- Process analytical technology (PAT) implementations for continuous manufacturing monitoring
FAQ
What pressure ratings are supported for UHPLC integration?
Rated for continuous operation up to 1300 bar; burst-tested to 1500 bar.
Is valve position feedback available?
Yes—mechanical end-stop detection and optional incremental encoder output support closed-loop positional verification.
Can the valve be cleaned in place (CIP)?
Fully compatible with common CIP protocols using 0.1 M NaOH, 20% isopropanol, or 0.5% phosphoric acid at ambient temperature.
Does AIGIS provide IQ/OQ documentation templates?
Yes—standard qualification packages (including test protocols, acceptance criteria, and raw data worksheets) are supplied upon order confirmation.
Are custom port layouts or non-standard actuation voltages supported?
OEM customization is available for port orientation, electrical interface (e.g., 12/24 VDC, 5 V TTL), and material substitutions (e.g., Hastelloy C-276 for halogenated solvent duty).
