ALISN THA-150 Temperature and Humidity Controlled Environmental Chamber

Overview

The ALISN THA-150 is a precision-engineered upright temperature and humidity controlled environmental chamber designed for long-term stability-critical applications in pharmaceutical stability testing, food shelf-life evaluation, polymer aging studies, material conditioning per ASTM D618 and ISO 291, and biological sample acclimatization. It operates on a dual-loop control architecture: a primary PID-fuzzy hybrid algorithm governs refrigeration and heating actuation, while a secondary feedback loop dynamically adjusts humidification output based on real-time dew point compensation. The chamber achieves thermal equilibrium through a variable-frequency compressor system paired with an optimized air distribution manifold—ensuring uniform airflow across the entire working volume without hot/cold stratification. Its structural integrity derives from monolithic polyurethane foam insulation (≥40 mm thickness, closed-cell density >38 kg/m³), which delivers superior thermal resistance (U-value <0.25 W/m²·K) and mechanical rigidity compared to segmented or bonded alternatives. All critical components—including the SECOP BD50F hermetic compressor, EBM-Papst EC centrifugal condenser fan, and E+E EE210 capacitive humidity transducer—are sourced from Tier-1 European OEMs and validated for continuous operation under Class II environmental conditions (IEC 60068-2).

Key Features

• True-color 7-inch capacitive touchscreen interface with intuitive icon-driven navigation and bilingual (English/Chinese) language toggle—no firmware update required for language switching.
• Immutable data logging system storing up to three years of minute-interval temperature/humidity readings; logs are write-once, exportable only via physically authenticated USB drive—no network-based modification vector.
• Comprehensive audit trail capturing 16,000+ time-stamped events including parameter changes, door openings, alarm triggers, and user logins—each entry cryptographically timestamped and exportable in CSV format compliant with FDA 21 CFR Part 11 Annex 11 requirements.
• Multi-level permission management supporting five distinct user roles (Admin, Supervisor, Technician, Viewer, Auditor) with granular access control over calibration, program editing, data export, and alarm acknowledgment functions.
• Multi-point temperature offset correction capability: users may apply independent bias adjustments at up to six spatially distributed sensor locations to compensate for localized thermal gradients—essential for validation against ISO 14644-3 spatial uniformity criteria.
• Integrated frost-free refrigeration cycle utilizing R134a refrigerant and adaptive defrost logic that activates only when evaporator coil frost accumulation exceeds 0.3 mm—reducing energy consumption by ≥40% versus fixed-interval systems.

Sample Compatibility & Compliance

The THA-150 accommodates standard ISO/IEC 17025-compliant test specimens up to 600 mm wide × 620 mm high × 405 mm deep, with optional stainless-steel shelving (two standard tiers, upgradeable to three). Its internal chamber features a double-door design: outer door with magnetic seal and inner tempered glass viewport enabling non-intrusive observation without thermal disturbance. A 50 mm diameter silicone-gasketed port on the right side permits feedthrough of sensor cables or gas lines while maintaining environmental integrity. The unit complies with electromagnetic compatibility standards IEC 61326-1 and safety directives IEC 61010-1. Its data integrity framework satisfies core GLP and GMP principles—particularly traceability (audit trail), reproducibility (PID tuning logs), and data immutability (USB-exported logs lack editable metadata fields). For regulated environments, optional IQ/OQ documentation packages are available upon request.

Software & Data Management

No proprietary PC software is required for basic operation—the THA-150 functions autonomously with embedded firmware v3.2. However, its RS232/RS485 interfaces support integration into enterprise-wide Environmental Monitoring Systems (EMS) using Modbus RTU protocol (slave ID configurable). Logged data exports as timestamped CSV files containing columns: UTC timestamp, chamber temperature (°C), setpoint temperature (°C), chamber RH (%), setpoint RH (%), compressor status (ON/OFF), heater status (ON/OFF), humidifier status (ON/OFF), and alarm code (hexadecimal). Each file includes SHA-256 checksums for integrity verification. Remote monitoring via Ethernet requires optional gateway module (ALISN-EMG-1); firmware updates are delivered via signed binary packages verified using X.509 certificate chain.

Applications

• ICH Q1A(R2) long-term and accelerated stability studies for pharmaceutical dosage forms (25 °C/60 % RH, 30 °C/65 % RH, 40 °C/75 % RH).
• ASTM D4332 conditioning of plastic specimens prior to tensile or impact testing.
• ISO 6270-2 humidity exposure tests for corrosion resistance evaluation of coated metals.
• Moisture sorption isotherm determination for hygroscopic food powders and excipients.
• Biological reagent storage conditioning per CLSI GP35-A4 guidelines (e.g., 2–8 °C with 45–65 % RH for lyophilized antibodies).
• Electronics component burn-in testing requiring precise thermal ramping and dwell profiles.

FAQ

What is the maximum allowable ambient temperature for continuous operation?
The THA-150 is rated for uninterrupted use in ambient environments between 5 °C and 35 °C; optimal performance is achieved at 25 °C ±2 °C with ≤70 % RH.
Can the chamber be validated per IQ/OQ protocols?
Yes—ALISN provides customizable IQ/OQ templates aligned with ASTM E2500 and EU Annex 15; installation qualification includes thermocouple mapping per ISO 14644-3, operational qualification covers ramp rate verification and stability hold testing.
Is remote access supported natively?
Native Ethernet connectivity is not included but can be added via the ALISN-EMG-1 gateway module, enabling SNMP-based monitoring and TLS-encrypted data transmission to cloud platforms.
How is humidity calibrated?
The E+E EE210 sensor supports two-point calibration (11 % RH saturated LiCl, 75 % RH saturated NaCl) using ALISN-certified calibration kits; calibration coefficients are stored in non-volatile memory and applied automatically during runtime.
Does the unit meet energy efficiency standards?
It exceeds China’s GB 30254-2013 Level 1 energy efficiency rating and qualifies for EU Ecodesign Regulation (EU) 2019/2021 standby power limits (<0.5 W).