ALISN THA-150S Dual-Compartment Temperature and Humidity Controlled Chamber

Overview

The ALISN THA-150S is a dual-compartment, upright temperature and humidity controlled chamber engineered for high-fidelity environmental simulation in regulated laboratory and industrial settings. Unlike single-chamber designs, its two independent 150 L workspaces operate simultaneously under distinct thermal-hygrometric profiles—enabling parallel testing of divergent samples or sequential condition transitions without cross-contamination or downtime. The system employs a dual-loop, air-cooled refrigeration architecture with SECOP (Danfoss Group) compressors and EBM-Papst condenser fans, delivering precise, low-drift climate control across the full operational envelope of −10 °C to +85 °C and 10–98 %RH. Its control core integrates PID regulation with adaptive fuzzy logic algorithms to minimize overshoot and accelerate recovery after door openings—critical for stability-sensitive applications such as accelerated stability testing per ICH Q1 guidelines. The chamber’s structural integrity and thermal efficiency are reinforced by monolithic polyurethane foam insulation (≥80 mm), reducing energy consumption by over 40 % compared to conventional chambers of equivalent volume.

Key Features

• Dual independent 150 L stainless-steel workspaces with separate temperature/humidity control loops and real-time monitoring
• 7-inch full-color capacitive touchscreen interface with intuitive menu navigation and bilingual (English/Chinese) language support
• Embedded audit trail system compliant with FDA 21 CFR Part 11 requirements: stores up to 16,000 immutable operation and alarm logs, exportable via USB
• Granular user permission management supporting five distinct roles (e.g., Operator, Supervisor, QA Auditor, Calibration Technician, Administrator)
• Multi-point temperature calibration function to correct spatial nonlinearity across the chamber volume
• Capacitive humidity sensors from E+E Elektronik (Austria) and platinum RTD temperature sensors from Heraeus (Germany) ensure long-term metrological stability without routine recalibration
• Robust safety architecture including overtemperature, overpressure, low-water, door-open, sensor-failure, and earth-leakage protection
• Standard communication interfaces (RS232, RS485, USB) enable seamless integration into LIMS, SCADA, or MES platforms for automated data acquisition and remote supervision

Sample Compatibility & Compliance

The THA-150S accommodates a broad spectrum of sample types—including pharmaceutical dosage forms, polymer films, food packaging materials, electronic components, and biological reagents—within its dual stainless-steel chambers. Its design conforms to ISO 17025:2017 requirements for environmental test equipment used in accredited laboratories. The chamber supports validation protocols aligned with ASTM E2234 (Standard Practice for Validation of Environmental Chambers), ICH Q5C (Stability Testing of Biotechnological/Biological Products), and USP (Environmental Control). All critical parameters—including temperature uniformity, humidity accuracy, and recovery time—are verified under empty-chamber conditions per ISO 16770:2020, with traceable calibration certificates available upon request. The dual-compartment configuration facilitates bracketing studies, reference-standard co-location, and comparative aging experiments under identical ambient conditions.

Software & Data Management

Data integrity is maintained through a write-once, read-many (WORM) logging architecture: all raw temperature/humidity readings, setpoint changes, alarm events, and user actions are timestamped and stored in encrypted internal memory for ≥10 years. Export is restricted to USB mass-storage mode; files are generated in CSV format and cannot be edited post-export—ensuring compliance with GLP/GMP data governance mandates. The embedded operating system provides real-time trend visualization, historical curve overlay, and customizable report templates. Optional PC-based software (ALISN ChamberLink™) extends functionality with automated report generation, multi-chamber fleet monitoring, and electronic signature workflows compliant with 21 CFR Part 11 Annex 11.

Applications

• Accelerated stability testing of pharmaceuticals and medical devices per ICH Q1A(R3) and ISO 11607
• Material aging and degradation studies in polymers, composites, and adhesives per ASTM D3045 and ISO 4892
• Food shelf-life prediction and packaging barrier performance evaluation per ISO 2233 and ASTM F1249
• Electronics reliability testing under combined thermal-hygrometric stress per JEDEC JESD22-A101 and IPC-9701
• Biological sample conditioning for cell culture media stability, enzyme activity assays, and diagnostic reagent qualification
• Calibration verification of portable hygrometers and thermometers in metrology labs

FAQ

What regulatory standards does the THA-150S support for validation and qualification?
The chamber meets foundational requirements for IQ/OQ/PQ execution per GAMP 5, with documentation packages aligned to ASTM E2234, ISO 16770, and EU Annex 15. Full 21 CFR Part 11 compliance is achievable with optional software and procedural controls.
Can both compartments run at different temperature/humidity setpoints simultaneously?
Yes—each 150 L chamber has independent PID+fuzzy controllers, sensors, and actuation systems, enabling fully decoupled environmental profiles.
Is the data logging system compliant with FDA 21 CFR Part 11?
Yes: audit trail, electronic signatures, and data immutability are implemented at firmware level; no third-party middleware is required for basic compliance.
What is the typical recovery time after a 30-second door opening at 40 °C/75 %RH?
Under standard test conditions (empty chamber, ambient 25 °C), temperature recovers to ±0.2 °C and humidity to ±1.5 %RH within ≤4.5 minutes.
Does the THA-150S include factory calibration certificates?
Yes—each unit ships with NIST-traceable calibration reports for temperature and humidity sensors, valid at time of shipment. On-site IQ/OQ services are available upon request.