ALISN THA760 Temperature and Humidity Controlled Chamber

Overview

The ALISN THA760 Temperature and Humidity Controlled Chamber is an engineered environmental test system designed for precise, long-term stability in regulated laboratory and industrial settings. It operates on the principle of dual-loop feedback control—separate PID-fuzzy hybrid algorithms independently govern refrigeration, heating, and humidification subsystems—to maintain traceable, repeatable conditions across its full operational envelope. The chamber meets the physical conditioning requirements specified in pharmacopeial standards (e.g., ICH Q1A–Q1E, USP ) and supports stability testing protocols compliant with ISO 17025-accredited laboratories. Its structural architecture integrates high-efficiency thermal management, corrosion-resistant stainless steel interior, and a validated air circulation design ensuring uniform exposure across the 760 L working volume—critical for accelerated aging studies, shelf-life determination, and material compatibility assessments.

Key Features

• Advanced dual-stage climate control: Independent regulation of temperature (−10 °C to 85 °C) and relative humidity (15–98 % RH) with ±0.3 °C and ±1.5 % RH accuracy under load, verified per ASTM E145 Annex A3.
• High-reliability refrigeration: SECOP (Danfoss Group) hermetic compressor paired with EBM Germany axial-flow condenser fan and R404a refrigerant; enables frost-free continuous operation and rapid recovery (<5 min) after 30-second door opening at 40 °C/75 % RH.
• Capacitive humidity sensing: Factory-calibrated E+E Elektronik EE210 sensor with NIST-traceable certificate, drift <±0.1 % RH/year, maintenance-free over 5-year service life.
• Thermal integrity: 100 mm monolithic polyurethane insulation (density ≥38 kg/m³), reducing energy consumption by ≥40 % versus conventional chambers of comparable volume.
• Secure data governance: Embedded real-time logging (1-minute resolution, 3-year buffer), cryptographic write protection, and audit-trail functionality supporting 21 CFR Part 11 compliance—including immutable event timestamps, operator ID, and parameter-change records.
• Human-centered interface: 7-inch resistive-capacitive touchscreen with bilingual (English/Chinese) menu navigation, multi-point temperature offset correction, and intuitive graphical trend display (real-time + 10-hour history).

Sample Compatibility & Compliance

The THA760 accommodates diverse sample configurations—including stacked trays, stacked cartons, pharmaceutical blister packs, polymer films, electronic assemblies, and biological specimens—within its 1200 × 1180 × 540 mm stainless steel chamber. Its triple-sealed double-glass viewing door (tempered inner pane, silicone gasketed outer frame) minimizes radiant heat loss while enabling non-intrusive visual monitoring. All materials contacting the test environment conform to USP Class VI biocompatibility and RoHS 2011/65/EU directives. The system supports validation documentation packages (IQ/OQ/PQ) aligned with GMP Annex 15 and ISO 13485:2016. Optional calibration ports (50 mm silicone gland) permit integration of external reference sensors for third-party verification.

Software & Data Management

The embedded controller firmware provides native support for GLP/GMP workflows: user authentication (5-tier role-based access), electronic signatures, and tamper-evident data export via USB 2.0. Logged datasets include timestamped temperature/humidity values, alarm events (e.g., over-temperature, low-water, sensor fault), and manual intervention logs—all stored in CSV format with SHA-256 hash integrity verification. Optional PC software (ALISN EnviroLink™) enables remote monitoring via RS485 Modbus RTU or Ethernet (with add-on module), automated report generation (PDF/XLSX), and statistical process control (SPC) charting per ISO 7870-2. All software modules are developed in accordance with IEC 62304 Class B safety requirements.

Applications

• Pharmaceutical stability testing per ICH Q5C and WHO TRS 953 Annex 2, including long-term (25 °C/60 % RH), intermediate (30 °C/65 % RH), and accelerated (40 °C/75 % RH) conditions.
• Food packaging barrier property evaluation under controlled humidity gradients (ASTM F1249, ISO 15106-3).
• Polymer aging and dimensional stability assessment (ISO 291, ASTM D618).
• Electronics reliability screening (JEDEC JESD22-A110, MIL-STD-810H Method 507.6).
• Reference material storage and calibration standard conditioning (ISO/IEC 17025 Clause 7.2.2).
• Biological sample preconditioning prior to mechanical or spectroscopic analysis.

FAQ

What is the chamber’s temperature and humidity recovery time after door opening?
At nominal operating conditions (40 °C / 75 % RH), the THA760 restores setpoint within ≤4.8 minutes following a 30-second door opening—verified per ASTM E145 Section 7.5.
Does the system support external data acquisition via SCADA or LIMS integration?
Yes—RS232/RS485 Modbus RTU protocol is natively supported; optional Ethernet gateway enables OPC UA or MQTT connectivity for enterprise-level lab informatics systems.
Can the internal volume be customized with additional shelving or fixtures?
Standard configuration includes three adjustable 304 stainless steel shelves; custom perforated trays, hanging rails, or humidity-diffusion baffles are available upon request with engineering review.
Is factory calibration certification included with shipment?
Each unit ships with a NIST-traceable calibration certificate covering temperature (−10 °C to 85 °C) and humidity (20–80 % RH) at three spatial points, performed per ISO/IEC 17025 accredited procedures.
What maintenance intervals are recommended for sustained performance?
Compressor oil and refrigerant charge require no routine servicing; annual verification of sensor calibration, door seal integrity, and condensate drain function is advised per manufacturer’s PM schedule (document PMA-THA-2024).