Annuo AS-3016B Multifunctional Liquid Autosampler
| Brand | Annuo |
|---|---|
| Origin | Henan, China |
| Manufacturer Type | Authorized Distributor |
| Product Category | Domestic |
| Model | AS-3016B |
| Instrument Type | Multifunctional Autosampler |
| Maximum Sample Capacity | 160 positions |
| Minimum Injection Volume | 0.1 µL |
| Quantitative Loop Volumes | 0.5, 1, 5, 10, 25, 50, and 500 µL |
| Positioning Accuracy | ≤ 0.3 mm |
| Motion System | XYZ three-axis robotic arm |
| Needle Wash Cycles | up to 99 |
| Re-injection Repetitions | up to 99 |
Overview
The Annuo AS-3016B Multifunctional Liquid Autosampler is a high-precision, modular robotic sampling system engineered for integration with gas chromatography (GC), liquid chromatography (HPLC/UHPLC), and capillary electrophoresis (CE) platforms. Designed as a scalable extension of the AS-3016A platform, the AS-3016B implements a human-arm-inspired XYZ three-axis motion architecture to execute repeatable, traceable liquid handling tasks—including vial piercing, aspiration, dispensing, needle washing, and barcode-assisted sample registration. Its core function is to replace manual injection workflows in regulated analytical laboratories, thereby minimizing operator-induced variability, improving inter-batch reproducibility, and supporting unattended operation over extended runtime windows (e.g., overnight or weekend sequences). The system operates on deterministic motion control algorithms, ensuring positional repeatability within ±0.3 mm across the entire 160-position sample deck—critical for consistent septum penetration and low-volume transfer fidelity.
Key Features
- Modular sample tray design accommodates multiple vial formats (e.g., 1.5 mL, 2 mL, 4 mL, and 10 mL screw-thread or crimp-top vials), enabling flexible method development and cross-platform compatibility.
- Intelligent sample detection: optical sensors automatically scan tray positions to identify empty or missing vials, skipping non-target locations without interrupting sequence execution.
- Integrated barcode reader supports GS1-compliant 1D/2D symbologies (Code 128, QR, DataMatrix), enabling automatic sample ID mapping to LIMS or CDS workstations via standard RS-232 or USB virtual COM port protocols.
- Optional thermal modules provide precise temperature control (±0.5 °C) across the sample tray—configurable for refrigeration (4–10 °C) or heating (up to 60 °C)—to preserve thermolabile analytes or maintain viscosity consistency during sequential analysis.
- On-deck sample homogenization: programmable vortex mixing (500–2500 rpm, 0–30 s duration) ensures uniform suspension of particulates or viscous matrices prior to aspiration, reducing pipetting bias and enhancing quantitative accuracy.
- Multi-stage needle wash station with solvent selection (up to 3 independent wash solvents) and configurable rinse cycles (1–99 passes per injection) minimizes carryover to < 0.005% for high-sensitivity applications.
Sample Compatibility & Compliance
The AS-3016B supports standard chromatographic consumables including glass and polypropylene vials (8–12 mm diameter), crimp caps with PTFE/silicone septa, and low-retention syringe needles (22–26 gauge). It complies with fundamental mechanical safety requirements per IEC 61000-6-2 (immunity) and IEC 61000-6-3 (emissions). While not certified to ISO/IEC 17025 or FDA 21 CFR Part 11 out-of-the-box, its audit-trail-capable firmware (v3.2+) logs all critical events—including injection timestamp, vial ID, loop volume selected, wash cycle count, and error codes—with optional CSV export for GLP/GMP-aligned documentation. When deployed with validated CDS software (e.g., Chromeleon, OpenLab CDS, or Empower), the system supports electronic signatures, user access levels, and change control procedures required under pharmaceutical quality systems.
Software & Data Management
The AS-3016B communicates via ASCII-based command protocol over USB or RS-232, allowing native integration with major chromatography data systems without proprietary drivers. A standalone Windows-based configuration utility (Annuo AutoConfig v2.4) enables method setup—including sequence definition, loop volume assignment, mixing parameters, and thermal profile scheduling—as well as real-time status monitoring and diagnostic logging. All operational metadata (start time, completion time, error flags, maintenance alerts) are timestamped and stored locally on internal flash memory (≥10,000 entries), with optional network upload via FTP or SMB to centralized lab servers. Firmware updates preserve calibration constants and user-defined tray maps, ensuring continuity across version upgrades.
Applications
- High-throughput QC testing in pharmaceutical manufacturing (e.g., assay, dissolution, residual solvent analysis per USP & EP monographs).
- Environmental analysis requiring multi-analyte screening (e.g., EPA Method 524/8260 for VOCs; 8082 for PCBs) across large sample sets.
- Food & beverage labs performing pesticide residue quantification (AOAC 2007.01), mycotoxin profiling, or fatty acid methyl ester (FAME) analysis by GC-FID.
- Academic and contract research laboratories conducting method validation studies where injection precision (RSD < 0.5% at ≥1 µL) and carryover control are mandatory.
- Forensic toxicology workflows involving blood, urine, or tissue extracts where chain-of-custody integrity is enforced through barcode-linked sample tracking.
FAQ
What is the minimum injection volume supported by the AS-3016B?
The system achieves reliable aspiration and dispensing down to 0.1 µL using compatible low-volume quantitative loops and positive-displacement syringes.
Can the AS-3016B be used with both HPLC and GC systems?
Yes—it supports standard high-pressure liquid injection (up to 600 bar) and gas-phase vaporization via compatible injector interfaces; valve timing and dwell settings are configured in the host CDS.
Is remote monitoring or troubleshooting possible?
Diagnostic mode enables serial console access for real-time motor current readings, sensor status, and firmware revision reporting; remote assistance requires local network access and prior authorization.
How is calibration verified and maintained?
Positional accuracy is factory-verified using laser interferometry; users perform routine verification using NIST-traceable micrometer targets and log results per internal SOP—no field recalibration tools are shipped.
What warranty and technical support does Annuo provide internationally?
The AS-3016B carries a 12-month limited warranty covering material and workmanship defects; Annuo’s global distributor network provides localized service contracts, spare parts logistics, and firmware update notifications via registered email.
