ANYAN AYAN-B80 Laboratory-Scale Wiped-Film Evaporator

Overview

The ANYAN AYAN-B80 Laboratory-Scale Wiped-Film Evaporator is a precision-engineered short-path distillation system designed for thermal-sensitive, high-boiling, or viscous liquid mixtures under high vacuum (≤1 Pa). It operates on the principle of molecular distillation—where the mean free path of vapor molecules exceeds the distance between the evaporating surface and the condensing surface—enabling separation based on differences in molecular volatility rather than boiling point alone. Unlike conventional batch distillation, this system forms a dynamic, ultra-thin liquid film (typically <0.5 mm) via a rotating PTFE- and SS316L-coated wiper blade assembly, ensuring minimal residence time (<60 seconds), uniform heat transfer, and negligible thermal degradation. Its cylindrical double-jacketed evaporation chamber, coupled with an integrated dual-stage condenser and programmable temperature control, supports reproducible, scalable purification workflows in research and pilot-scale development environments.

Key Features

• Stainless steel 316L construction with PTFE-coated wiper blades for exceptional corrosion resistance and compatibility with aggressive solvents (e.g., chlorinated hydrocarbons, organic acids)
• Precisely adjustable rotational speed (0–300 rpm) and heating jacket temperature (ambient to 300 °C) for fine-tuned film formation and evaporation kinetics
• Dual-stage condenser with independent −20 °C refrigerated coolant loop ensures >95% vapor capture efficiency, even for low-volatility compounds
• Hermetic sealing using fluorosilicone gaskets (upgradable to perfluoroelastomer for extreme chemical resistance) maintains stable vacuum integrity below 1 Pa
• Modular feed system with calibrated peristaltic pump (optional pre-heating to 300 °C) enables continuous or semi-batch operation with flow control from 0–4 L/h
• Integrated vacuum monitoring (capacitance manometer), pressure regulation valve, and safety interlocks compliant with IEC 61000-6-2/6-4 electromagnetic compatibility standards

Sample Compatibility & Compliance

The AYAN-B80 accommodates a broad range of thermally labile and high-viscosity feedstocks—including fish oil triglycerides (≥1000 cP at 60 °C), pharmaceutical intermediates (e.g., vitamin A palmitate, squalene), polymer precursors (e.g., epoxy resins, silicone monomers), and natural extracts (e.g., lanolin, aromatic essential oils). All wetted surfaces meet USP Class VI and FDA 21 CFR Part 11 requirements for material traceability and surface finish (Ra ≤ 0.8 µm). The system is validated for GLP-compliant operation when paired with optional audit-trail-enabled software (see Software & Data Management). It supports ASTM D2872 (vacuum distillation of petroleum products), ISO 11348 (toxicity testing of distillates), and EU Pharmacopoeia 2.2.27 (purification of active pharmaceutical ingredients).

Software & Data Management

When equipped with the optional ANYAN ControlSuite™ v3.2, the evaporator provides full digital workflow integration: real-time logging of vacuum pressure, jacket temperature, condenser temperature, rotational speed, and feed rate; automated sequence programming (e.g., ramp-hold-cool cycles); and export of timestamped CSV/Excel reports compatible with LIMS platforms. Audit trails include user ID, timestamp, parameter changes, and system alarms—all compliant with 21 CFR Part 11 electronic record requirements. Data encryption (AES-256), role-based access control, and backup to network drives or cloud storage ensure data integrity across multi-user laboratory environments.

Applications

• Fine Chemicals: Purification of fragrance esters, chiral intermediates, and oligomeric siloxanes without racemization or decomposition
• Pharmaceuticals: Solvent removal from API solutions, isolation of unstable vitamins (e.g., retinol, tocopherol), and deacidification of fatty acid derivatives
• Food & Nutraceuticals: Concentration of omega-3 ethyl esters from fish oil, removal of off-flavor volatiles, and fractionation of plant sterols
• Materials Science: Degassing of prepolymer melts prior to casting, purification of liquid crystal monomers, and recovery of catalyst residues from polymerization effluents
• Environmental Analysis: Pre-concentration of persistent organic pollutants (POPs) from aqueous extracts prior to GC-MS analysis

FAQ

What vacuum level is required for optimal molecular distillation performance?

A base pressure ≤1 Pa (≈0.0075 mTorr) is recommended to ensure the mean free path exceeds the evaporator-to-condenser gap (typically 50–80 mm), enabling true molecular regime operation.

Can the AYAN-B80 handle feedstocks with viscosity above 5,000 cP?

Yes—its torque-optimized 200 W motor and 45° angled wiper geometry maintain stable film formation up to ~8,000 cP at 80 °C, provided pre-heating and controlled feed rate are applied.

Is the system suitable for GMP manufacturing environments?

While designed for R&D and pilot scale, it meets core GMP design principles (cleanability, material certification, documentation support); formal qualification (IQ/OQ/PQ) is achievable with optional validation packages.

How is cleaning and maintenance performed between runs?

All major components are accessible without tools; the evaporator cylinder and condenser can be dismantled for solvent rinsing or ultrasonic cleaning; wiper blades are field-replaceable and certified for ≥500 operational hours.

Does the system support inert gas purging for oxygen-sensitive materials?

Yes—integrated gas inlet ports (SS316L, Swagelok®) allow nitrogen or argon sparging before and during operation to suppress oxidation of unsaturated lipids or polyphenols.