Anyan AYAN-F150 Molecular Distillation Instrument
| Origin | Zhejiang, China |
|---|---|
| Manufacturer Type | Distributor |
| Origin Category | Domestic (China) |
| Model | AYAN-F150 |
| Price | ¥21,500 |
| Feed Capacity | 2 L |
| Effective Evaporation Area | 0.25 m² |
| Evaporator Inner Diameter | 150 mm |
| Collecting Flasks | 2 units |
| Condensation Area | 0.45 m² |
Overview
The Anyan AYAN-F150 Molecular Distillation Instrument is a precision-engineered short-path molecular distillation system designed for high-efficiency thermal separation of heat-sensitive, high-boiling-point, and thermally labile compounds under ultra-high vacuum conditions. Unlike conventional distillation—governed by vapor–liquid equilibrium at or near boiling points—molecular distillation operates in the free-molecular flow regime, where the mean free path of vapor molecules exceeds the distance between the heated evaporation surface and the cooled condensing surface. This enables separation based on differences in molecular weight and volatility, rather than boiling point alone. The AYAN-F150 achieves operational pressures down to 0.001 mbar, facilitating evaporation at significantly reduced temperatures—typically 30–100 °C below atmospheric boiling points—thereby minimizing thermal degradation, polymerization, or oxidative decomposition. Its core architecture integrates a vertically oriented falling-film evaporator with an internal concentric condenser, ensuring direct molecular trajectory from heating surface to condensing surface with minimal residence time (<30 seconds) and negligible back-scattering.
Key Features
- Stainless-steel construction (316L grade) for corrosion resistance and vacuum integrity, compliant with ISO 8573-1 Class 2 clean compressed air standards for auxiliary systems.
- Heated evaporator cylinder with precise PID-controlled temperature regulation (range: ambient to 250 °C; accuracy ±0.5 °C), paired with a separately controlled internal condenser (cooling range: −20 to +10 °C).
- Motor-driven PTFE-coated wiper rotor operating at adjustable speeds (50–400 rpm), ensuring uniform thin-film formation (<0.1 mm thickness) across the 150 mm inner-diameter evaporation surface (0.25 m² effective area).
- Dual independent collection flasks (standard 1 L each, customizable volume and neck configuration), mounted on a rotatable manifold with vacuum-tight PTFE stopcocks for sequential or parallel fraction collection.
- Integrated high-vacuum system including dual-stage oil-sealed rotary vane pump and optional cold trap (−50 °C), capable of sustaining stable base pressure ≤1 × 10⁻³ mbar during operation.
- Condenser geometry optimized for maximum surface area (0.45 m²) and minimal thermal resistance, featuring polished stainless-steel walls and axial coolant flow distribution for uniform temperature gradient.
Sample Compatibility & Compliance
The AYAN-F150 is validated for processing viscous, non-Newtonian, and thermally unstable feedstocks—including natural oils (fish oil, krill oil, borage oil), phospholipids, vitamin concentrates (vitamin A, E, K), cannabinoids (CBD distillate purification), polyphenols, and specialty polymers (e.g., silicone oligomers). It supports batch processing of up to 2 L per cycle with consistent film stability and reproducible separation efficiency (typical recovery >92% for target fractions). The system complies with general laboratory safety requirements per IEC 61010-1 and incorporates vacuum interlock circuits to prevent accidental exposure during operation. While not certified for GMP manufacturing, its design accommodates GLP-aligned documentation practices—including manual logbook entries for temperature, pressure, feed rate, and collection timing—supporting audit readiness for R&D and pilot-scale process development.
Software & Data Management
The AYAN-F150 operates via a dedicated front-panel HMI interface with real-time display of critical parameters: evaporator/condenser temperatures, vacuum level (capacitance manometer readout), rotor speed, and elapsed run time. Optional RS-485 Modbus RTU connectivity enables integration into centralized lab data acquisition systems (e.g., LabVIEW, DeltaV, or custom SCADA platforms) for automated parameter logging and trend analysis. All operational settings are password-protected and timestamped, supporting basic traceability requirements. Though it does not include FDA 21 CFR Part 11-compliant electronic signatures or audit trails as standard, the instrument’s deterministic control logic and hardware-based parameter limits facilitate validation protocols required for regulated environments when deployed with supplementary SOPs and procedural controls.
Applications
- Purification of omega-3 fatty acid ethyl esters (EPA/DHA) from crude fish oil hydrolysates, removing cholesterol, monoacylglycerides, and oxidation by-products.
- Deacidification and deodorization of edible and industrial triglyceride oils without stripping natural antioxidants (e.g., tocopherols).
- Isolation of monoglycerides and diglycerides for pharmaceutical excipient synthesis under low-thermal-stress conditions.
- Concentration and fractionation of natural carotenoids (astaxanthin, lutein) and chlorophyll derivatives from algal extracts.
- Removal of residual solvents (e.g., hexane, ethanol) and catalyst traces from synthetic intermediates in fine chemical synthesis.
- Preparative-scale separation of polymer oligomers by molecular weight cutoff, supporting structure–property correlation studies.
FAQ
What is the minimum achievable operating pressure for the AYAN-F150?
The system is engineered to sustain stable vacuum conditions down to 0.001 mbar (1 × 10⁻³ mbar) using the standard dual-stage rotary vane pump; performance may improve with optional cryogenic trapping.
Can the AYAN-F150 handle highly viscous feedstocks such as crude lanolin or rosin?
Yes—its high-torque wiper motor and adjustable rotor speed enable stable thin-film formation for feeds with viscosities up to 5,000 cP at processing temperature; pre-heating of feed vessel is recommended for optimal film continuity.
Is the condenser cooled by circulating chiller or dry ice?
The condenser accepts standard external recirculating chillers (−20 to +10 °C output); dry ice/acetone baths are not compatible due to thermal shock risk and lack of temperature control.
Does the instrument include vacuum measurement and control automation?
Yes—it features a digital capacitance manometer with real-time pressure readout and automatic pump speed modulation to maintain setpoint pressure within ±5% tolerance.
Are spare parts and technical support available outside China?
Anyan provides global distributor networks with localized technical documentation; key wear components (wiper blades, O-rings, gaskets) are stocked internationally and conform to ISO 3601-1 NBR/FKM specifications.
