Anyan AYAN-F60 Glass Molecular Distillation Instrument for Thermolabile Material Separation
| Brand | Anyan |
|---|---|
| Origin | Zhejiang, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | AYAN-F60s |
| Feed Capacity | 1 L |
| Effective Evaporation Area | 0.06 m² |
| Evaporator Internal Diameter | 60 mm |
| Collecting Flasks | 2 units |
| Condensation Area | 0.1 m² |
Overview
The Anyan AYAN-F60 is a laboratory-scale glass molecular distillation instrument engineered for high-precision, low-thermal-stress separation of thermolabile, high-boiling, and oxidation-sensitive compounds. Operating under ultra-high vacuum (≤0.1 Pa), it leverages the physical principle of molecular mean free path — where vapor molecules travel unimpeded from the heated evaporative surface to the opposing condenser surface without intermolecular collisions. This short-path geometry (evaporator-to-condenser distance < 50 mm) enables operation at temperatures significantly below conventional boiling points, with residence time on the heated surface limited to seconds. Unlike standard fractional or vacuum distillation, molecular distillation avoids bulk boiling, eliminating foaming, bumping, and thermal degradation. The AYAN-F60 is constructed entirely from borosilicate 3.3 glass (DIN/ISO-compliant), ensuring chemical inertness, optical clarity for process monitoring, and compatibility with aggressive solvents and extracts.
Key Features
- Glass construction (Borosilicate 3.3) with PTFE- and SS316L刮板 (wiper) assembly for corrosion resistance and uniform thin-film formation
- Effective evaporation area of 0.06 m² and condensation area of 0.1 m² — optimized for mass transfer efficiency and scalability from lab to pilot scale
- Integrated short-path design with internal condenser positioned directly opposite the heated evaporator surface
- Adjustable feed pre-heating capability via optional jacketed feed vessel, enabling precise thermal conditioning prior to film formation
- Dual collection flask configuration (2× standard ground-glass joints) for sequential or parallel fraction recovery
- Fluoroelastomer (FKM) gasket sealing system; optional perfluoroalkoxy (PFA) gaskets available for HF or strong oxidant applications
- Thin-film thickness control (<0.5 mm) via adjustable wiper speed and geometry — critical for minimizing thermal exposure and maximizing separation selectivity
- Compatible with external cryogenic cooling systems (e.g., liquid nitrogen cold traps or ethanol-based recirculating chillers) to maintain ≤0.1 Pa operating pressure
Sample Compatibility & Compliance
The AYAN-F60 supports a broad range of heat-sensitive matrices including natural product extracts (e.g., fish oil EPA/DHA concentrates, vitamin E acetate, phospholipids), polymer additives (e.g., silicone oils, plasticizers), fragrance isolates, and pharmaceutical intermediates. Its all-glass fluid path eliminates metal leaching and catalytic side reactions, preserving molecular integrity — essential for GLP-compliant natural product purification and USP-grade excipient refinement. While the instrument itself does not carry CE or UL certification, its modular design permits integration into ISO 17025-accredited laboratories when paired with validated vacuum measurement (capacitance manometer), temperature calibration (Pt100 traceable to NIST), and pressure-controlled automation. Vacuum performance meets ASTM D2879-18 requirements for molecular distillation characterization of high-boiling-point substances.
Software & Data Management
The AYAN-F60 operates as a manually supervised benchtop system; no embedded digital controller or proprietary software is included. However, it is fully compatible with third-party data acquisition platforms (e.g., LabVIEW, Python-based DAQ via RS485/Modbus RTU adapters) when integrated with optional digital temperature controllers, vacuum transducers, and flow meters. Users may implement 21 CFR Part 11-compliant audit trails by logging setpoints, actual temperatures, vacuum levels, and collection timing in validated electronic lab notebooks (ELNs). All glass components conform to ISO 3585 and DIN 12331 standards, and joint dimensions comply with ISO 29771 for interchangeability with major global labware suppliers.
Applications
- Deacidification and deodorization of edible oils and biodiesel feedstocks
- Concentration and purification of polyunsaturated fatty acids (PUFAs) without cis-trans isomerization
- Removal of residual solvents (e.g., hexane, ethyl acetate) post-extraction in botanical and cannabis processing
- Isolation of active constituents from essential oils (e.g., geraniol, linalool) while preserving chiral integrity
- Purification of synthetic lubricants, heat-transfer fluids, and monomeric precursors for specialty polymers
- Preparative-scale isolation of unstable APIs or prodrugs requiring solvent-free downstream processing
FAQ
What vacuum level is required for optimal operation?
The AYAN-F60 achieves highest separation efficiency at ≤0.1 Pa (≤1 × 10⁻³ mbar); this requires a two-stage vacuum system (rotary vane pump + diffusion or turbomolecular pump) and proper cold trapping.
Can the system be automated for unattended runs?
Yes — via external PID controllers and programmable logic controllers (PLCs); no built-in automation is provided, but all critical interfaces (temperature, pressure, rotation) are accessible for integration.
Is the wiper speed adjustable?
Yes — mechanical speed control allows adjustment between 0–300 rpm to optimize film thickness and heat transfer for varying feed viscosities.
What is the maximum recommended operating temperature for the heating mantle?
The standard oil bath heater supports up to 250 °C; for higher temperatures, users must verify thermal stability of the glass components and vacuum seals.
Are replacement parts (e.g., wipers, gaskets, condenser sleeves) available separately?
Yes — Anyan supplies OEM-certified spare parts with material traceability documentation, including SS316L wiper blades and FKM/FPA sealing kits.
