Anyty 3R-CLS200 Benchtop Single-Crystal X-ray Diffractometer with Integrated Water-Cooled X-ray Source

Overview

The Anyty 3R-CLS200 is a compact, benchtop single-crystal X-ray diffractometer engineered for high-fidelity structural characterization of crystalline materials. It operates on the Bragg diffraction principle, where monochromatic X-rays interact with periodic atomic lattices to generate constructive interference patterns governed by the equation nλ = 2d sinθ. The system integrates a sealed-tube X-ray source with an internal water-cooling loop—eliminating dependency on external chillers and enhancing thermal stability during extended data collection. Designed for laboratory environments with space constraints, the 3R-CLS200 delivers reproducible crystallographic data suitable for unit cell determination, space group assignment, and precise atomic coordinate refinement. Its angular accuracy of ±0.02° and resolution of 0.04° support reliable measurement of small angular deviations critical in strain analysis, phase transition studies, and twinning identification.

Key Features

• Benchtop footprint (≤0.8 m²) optimized for shared labs, teaching facilities, and QC environments without dedicated radiation shielding rooms.
• Integrated closed-loop water cooling system ensures stable anode temperature during continuous operation—reducing thermal drift and maintaining consistent X-ray intensity over multi-hour acquisitions.
• Motorized goniometer with high-precision stepper motors and optical encoder feedback enables accurate ω, 2θ, and φ axis control within ±0.02° angular tolerance.
• Modular detector interface supporting industry-standard CCD and hybrid pixel detectors (e.g., Pilatus or EIGER-compatible configurations) for flexible signal-to-noise optimization.
• Radiation safety compliance with IEC 61010-1 and national Class II X-ray equipment regulations; includes interlocked shutter, beam stop, and real-time dose monitoring.

Sample Compatibility & Compliance

The 3R-CLS200 accommodates standard single-crystal mounts—including Kapton loops, MiTeGen micromounts, and glass capillaries—with sample stage travel ranges of ±15° in ω and ±30° in 2θ. It supports cryogenic operation down to 100 K via optional nitrogen gas flow accessories. All hardware and firmware comply with ISO/IEC 17025 requirements for testing laboratories, and software workflows align with GLP documentation standards. Data files are generated in CIF-compliant .hkl and .raw formats, enabling direct import into SHELX, OLEX2, and JANA2020 for structure solution and refinement. The instrument meets ASTM E975 (Standard Practice for X-ray Diffraction Crystallography) and supports traceable calibration using NIST SRM 640e silicon reference powder.

Software & Data Management

Control and analysis are performed through the proprietary Anyty CrystalSuite™ v4.x platform—a Windows-based application with dual-mode operation: guided wizard mode for undergraduate instruction and expert mode for full parameter scripting. The software implements automated crystal centering, lattice indexing, and integration using the DirAx algorithm. All acquisition parameters, detector settings, and environmental logs (temperature, humidity, beam current) are embedded in metadata per frame. Audit trails conform to FDA 21 CFR Part 11 requirements, including electronic signatures, user role-based access control, and immutable raw-data archiving. Export options include CIF, mmCIF, and PDB formats for deposition in the Cambridge Structural Database (CSD) or Protein Data Bank (PDB).

Applications

• Geology & Exploration: Identification of mineral polymorphs (e.g., quartz vs. tridymite), quantification of clay mineral assemblages, and analysis of metamorphic textures from micro-samples.
• Ceramics & Advanced Materials: Phase purity verification of piezoelectric perovskites (e.g., BaTiO₃), residual stress mapping in sintered alumina, and epitaxial quality assessment of thin-film oxides.
• Pharmaceuticals & Biocrystallization: Polymorph screening of active pharmaceutical ingredients (APIs), chiral resolution validation, and solvate/hydrate structure confirmation under controlled humidity conditions.
• Academic Research & Education: Undergraduate crystallography labs, graduate-level structure solution projects, and method development for time-resolved diffraction experiments.
• Environmental & Catalysis Science: In situ characterization of supported metal catalysts (e.g., Pt/Al₂O₃) during thermal treatment, and identification of corrosion products on alloy surfaces.

FAQ

Is the 3R-CLS200 certified for use in regulated GMP environments?

Yes—when deployed with CrystalSuite™ in audit-trail mode and configured with appropriate SOPs, the system supports 21 CFR Part 11 compliance for data integrity in pharmaceutical and contract research settings.
Does it support in situ or time-resolved measurements?

The goniometer’s programmable scan speed (0.001–5°/min) and trigger-sync I/O port enable coupling with external stimuli (e.g., heating stages, gas flow controllers) for kinetic studies.
What maintenance is required for the integrated water-cooling system?

Annual replacement of deionized water and inspection of pump seals are recommended; no radiator cleaning or chiller servicing is needed due to the self-contained loop design.
Can raw diffraction images be processed externally?

Yes—proprietary .raw frames are stored in binary format with ASCII header metadata, fully compatible with open-source tools such as DIALS, XDS, and CCP4 suite.
Is remote operation supported?

CrystalSuite™ includes secure RDP-compatible remote desktop functionality with encrypted session logging, enabling off-site instrument monitoring and data collection supervision.