ASA AC2017-025050 Dynamic Axial Compression (DAC) Column Packing System
| Brand | ASA |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Product Category | Domestic |
| Model | AC2017-025050 |
| Instrument Type | Dynamic Axial Compression System |
| Compliance | ISO 9001 certified |
| Safety Certification | CE Marked |
| Compatible Column ID Range | 25–50 mm |
| Application | Preparative-Scale Chromatography, SFC Column Packing |
Overview
The ASA AC2017-025050 is a precision-engineered Dynamic Axial Compression (DAC) column packing system designed for reproducible, high-integrity packing of preparative chromatographic columns. Unlike static or manual packing methods, DAC technology applies controlled, continuous axial force during slurry packing and subsequent consolidation—minimizing void formation, ensuring uniform bed density, and maximizing column efficiency and lifetime. This system operates on a pneumatically actuated piston-cylinder mechanism with closed-loop pressure regulation, delivering smooth, pulse-free compression without mechanical backlash or hydraulic surge. It is specifically configured for use with preparative liquid chromatography (PLC), supercritical fluid chromatography (SFC), and flash chromatography systems where robust, scalable column performance is critical to method transfer and process validation.
Key Features
- Dynamic axial compression architecture with real-time pressure feedback control ensures consistent bed homogeneity across multiple packing cycles.
- Pneumatic drive system eliminates oil contamination risk and reduces maintenance requirements—no hydraulic fluid changes, seals, or leak-prone valves.
- Modular column holder design accommodates interchangeable stainless-steel or PEEK column bodies with internal diameters from 25 mm to 50 mm—enabling rapid reconfiguration between analytical-scale prep and pilot-scale applications.
- Integrated force calibration routine supports traceable compression force verification per ISO/IEC 17025 guidelines when used with accredited external load cells.
- CE-marked electrical and pneumatic subsystems comply with EN 61000-6-2 (EMC immunity) and EN 61000-6-4 (EMC emission) standards; full conformity documentation available upon request.
- Designed and manufactured under an ISO 9001:2015-certified quality management system, supporting audit readiness for GLP and GMP environments.
Sample Compatibility & Compliance
The AC2017-025050 supports a broad range of stationary phases—including silica gels, polymer-based resins, chiral selectors, and hybrid organic-inorganic materials—used in both normal-phase and reversed-phase preparative chromatography. Its low-vibration compression profile preserves particle integrity for fragile media such as monolithic silica or sub-2 µm core-shell particles. For SFC applications, the system maintains column integrity under CO₂-rich mobile phase conditions and enables stable packing at elevated backpressures up to 300 bar (when paired with compatible column hardware). All wetted components meet USP Class VI biocompatibility requirements, and surface finishes conform to ASME BPE-2022 standards for pharmaceutical-grade equipment.
Software & Data Management
While the AC2017-025050 operates as a standalone hardware platform, its pneumatic control interface includes analog 0–10 V and digital I/O ports compatible with third-party PLCs or SCADA systems for integration into automated purification suites. Optional firmware upgrades support time-stamped event logging (compression start/end, peak force, dwell duration) with CSV export capability—facilitating 21 CFR Part 11-compliant data archiving when deployed alongside validated electronic lab notebooks (ELNs) or LIMS platforms. Audit trail functionality records operator ID, timestamp, and parameter setpoints for each packing cycle, aligning with ALCOA+ data integrity principles.
Applications
- Reproducible packing of 25–50 mm ID preparative HPLC columns for API purification, natural product isolation, and chiral separation workflows.
- High-fidelity column fabrication for supercritical fluid chromatography (SFC), particularly in pharmaceutical development labs requiring rapid method scouting and scale-up fidelity.
- Method development support for orthogonal purification strategies involving mixed-mode or multimodal resins.
- Quality control laboratories performing column qualification per USP <621> and ICH Q5D guidelines, including flow profile assessment and asymmetry factor evaluation post-packing.
- Educational and contract research organizations requiring robust, entry-level DAC capability without proprietary software lock-in or vendor-specific consumables.
FAQ
What column diameters does the AC2017-025050 support?
It accommodates columns with internal diameters ranging from 25 mm to 50 mm, using standardized, tool-free column clamping fixtures.
Is the system compatible with SFC operating pressures?
Yes—the mechanical design and sealing architecture are rated for sustained operation at pressures up to 300 bar when used with appropriately rated column hardware and end-fittings.
Does the unit include pressure or force calibration certificates?
Factory calibration is performed per ISO 9001 procedures; optional UKAS-accredited calibration certificates are available upon request for metrological traceability.
Can the AC2017-025050 be integrated into a fully automated purification platform?
Yes—its analog/digital I/O interface enables synchronization with PLC-controlled solvent delivery, fraction collection, and UV monitoring subsystems.
What maintenance is required for long-term reliability?
No scheduled maintenance is required beyond periodic inspection of pneumatic fittings and O-rings; the system contains no lubricated moving parts or replaceable hydraulic components.
