AYAN AYAN-F100-S Lab-Scale Wiped-Film Molecular Distillation System
| Brand | AYAN |
|---|---|
| Origin | Zhejiang, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | AYAN-F100-S |
| Price | USD 25,000 (FOB) |
| Feed Rate | 0.5–5.0 L/h |
| Effective Evaporation Area | 0.15 m² |
| Evaporator Internal Diameter | 100 mm |
| Collection Flask Capacity | 2 L |
| Condenser Surface Area | 0.25 m² |
Overview
The AYAN AYAN-F100-S is a benchtop wiped-film molecular distillation system engineered for high-precision thermal separation of heat-sensitive, high-boiling-point compounds under ultra-high vacuum conditions (typically <0.001 mbar). Unlike conventional distillation, molecular distillation operates in the free-molecule flow regime—where the mean free path of vapor molecules exceeds the distance between evaporator and condenser surfaces—enabling separation based on differences in molecular weight and vapor pressure rather than boiling point alone. This principle is especially critical for isolating thermolabile natural products such as essential oils, polyunsaturated fatty acids (PUFAs), phospholipids, vitamin concentrates, and botanical extracts without thermal degradation. The AYAN-F100-S integrates a vertically oriented, gravity-fed evaporator with a rotating wiper mechanism to generate a uniform, thin film (<0.1 mm) across the heated stainless-steel surface, minimizing residence time (typically <30 seconds) and maximizing volatility-driven selectivity.
Key Features
- Wiped-film evaporator with precision-engineered PTFE-coated wiper blades ensuring consistent film thickness and minimal shear-induced decomposition
- High-purity 316L stainless-steel construction for all wetted parts—including evaporator body, condenser jacket, feed tube, and collection vessels—compliant with FDA-recommended materials for pharmaceutical and food-grade applications
- Integrated high-vacuum system capable of achieving and maintaining ≤1×10⁻³ mbar via dual-stage oil-sealed rotary vane pump and optional cold trap
- Programmable digital temperature control (±0.5 °C accuracy) for both heating mantle (up to 250 °C) and condenser (−20 to +20 °C, with chiller compatibility)
- Automated feed dosing via peristaltic pump with adjustable flow rate (0.5–5.0 L/h) and real-time level monitoring in feed reservoir
- Modular design allowing rapid disassembly for cleaning, validation, or replacement of critical components—fully traceable to ISO 9001 manufacturing standards
Sample Compatibility & Compliance
The AYAN-F100-S accommodates viscous, non-Newtonian, and particulate-containing feedstocks common in botanical processing—including crude essential oil distillates, CO₂ extracts, fish oil concentrates, and resin fractions—without clogging or film instability. Its geometry and material selection support operation within GLP-compliant laboratories and pilot-scale process development workflows aligned with ICH Q5A, USP , and ASTM D6304 guidelines for volatile organic analysis. While not certified for GMP production, the system’s documentation package—including IQ/OQ templates, calibration records, and material certificates—facilitates regulatory audit readiness for method transfer and tech transfer activities.
Software & Data Management
The embedded control interface provides local HMI-based operation with password-protected user levels (Operator, Technician, Administrator). All critical process parameters—including vacuum pressure, evaporator/condenser temperatures, feed rate, and run duration—are logged at 1-second intervals and exportable in CSV format. Optional Ethernet connectivity enables integration into laboratory information management systems (LIMS) and supports 21 CFR Part 11-compliant electronic signatures when paired with validated third-party software. Audit trails record operator actions, parameter changes, and alarm events—retained for ≥36 months per standard data integrity protocols.
Applications
- Purification of terpenes and oxygenated monoterpenes from citrus, lavender, and eucalyptus oils
- Deacidification and deodorization of omega-3-rich fish and krill oil concentrates
- Isolation of tocopherols and phytosterols from vegetable oil deodorizer distillates
- Removal of residual solvents (e.g., hexane, ethanol) from botanical extracts prior to formulation
- Preparative-scale fractionation of polyphenol glycosides and labile alkaloids under inert atmosphere (N₂ or Ar purge capability)
- Process optimization studies supporting scale-up to industrial wiped-film evaporators (e.g., for API intermediate purification)
FAQ
What vacuum level is required for optimal performance?
The system is designed to operate continuously at ≤1×10⁻³ mbar; stable operation below 5×10⁻⁴ mbar is achievable with optional cryogenic trapping and leak-tight assembly verification.
Can the unit handle feedstocks with suspended solids?
Yes—feed pre-filtration through 50–100 µm mesh is recommended; the wiper design tolerates up to 5 wt% fine particulates without film disruption.
Is validation documentation provided?
Standard delivery includes factory calibration reports, material traceability sheets (316L SS mill test reports), and IQ/OQ protocol templates compliant with ISO/IEC 17025 requirements.
What maintenance intervals are recommended?
Wiper blade inspection every 200 operational hours; vacuum pump oil change every 500 hours; full gasket replacement recommended annually or after 1,000 h cumulative use.
Does the system support inert gas sparging during distillation?
Yes—integrated inlet ports allow continuous N₂ or Ar purging of feed reservoir and evaporator headspace to minimize oxidation of unsaturated compounds.
