BRAND Titrette® 4760151 Digital Burette Dispenser (25 mL)

Overview

The BRAND Titrette® 4760151 Digital Burette Dispenser is a precision-engineered electronic bottle-top titrator designed for volumetric analysis in regulated laboratory environments. Operating on the principle of motor-assisted piston displacement with integrated optical position sensing and real-time flow monitoring, it delivers traceable, repeatable liquid delivery across its full 25 mL range. Unlike traditional manual burettes or basic digital dispensers, the Titrette® 4760151 employs bidirectional rotary actuation—clockwise rotation initiates dispensing, counterclockwise triggers aspiration—eliminating mode-switching buttons and reducing procedural errors. Its mechanical architecture conforms to ISO 8655-3:2022 for piston burettes, ensuring metrological validity for applications requiring GLP/GMP-compliant documentation. The device is calibrated per manufacturer’s certified procedures using gravimetric methods traceable to national standards (e.g., PTB, NIST), with calibration data stored internally and exportable via optional RS-232 interface.

Key Features

• High-precision dispensing with accuracy ≤ ±0.07% (≤ ±18 µL) and CV ≤ 0.025% (≤ 6 µL) at full scale—validated per ISO 8655-3 requirements.
• Intuitive bidirectional rotary control: no mode buttons required; direction-sensing logic automatically distinguishes between aspiration and dispensing.
• Modular, service-friendly design: all wetted parts—including PTFE-coated piston, glass barrel, and dispensing tip—are independently replaceable and compatible with autoclaving (121 °C, 20 min), excluding electronic housing.
• On-device calibration support via EasyCal™ software: enables user-performed recalibration with documented audit trail, including date, operator ID, and deviation values.
• Configurable display settings: decimal resolution adjustable from 0.001 mL to 0.01 mL; backlit LCD ensures readability under variable lab lighting conditions.
• Energy-efficient operation: rechargeable NiMH battery supports >1,000 full-cycle operations per charge; automatic shutdown after 15 minutes of inactivity.

Sample Compatibility & Compliance

The Titrette® 4760151 is chemically compatible with aqueous solutions, organic solvents (e.g., ethanol, acetone, chloroform), and dilute acids/bases when used with standard PTFE/glass wetted materials. It is not recommended for strongly oxidizing agents (e.g., concentrated HNO₃, aqua regia) or hydrofluoric acid. All configurations comply with ISO 8655-3 for volumetric accuracy verification and are suitable for use in laboratories adhering to ISO/IEC 17025, USP , and EP 2.2.39. When paired with validated calibration protocols and electronic audit trail enabled (via RS-232 + compliant LIMS), the system supports FDA 21 CFR Part 11 requirements for electronic records and signatures.

Software & Data Management

While standalone operation requires no software, the optional RS-232 interface enables direct integration with laboratory information management systems (LIMS) or custom data acquisition platforms. Exported data includes timestamped volume dispensed, cycle count, calibration history, and error logs (e.g., air bubble detection, over-pressure alerts). EasyCal™ desktop software (Windows/macOS) provides guided calibration workflows, generates PDF calibration certificates compliant with ISO/IEC 17025 Annex A.2, and stores historical performance trends for preventive maintenance scheduling. All electronic records retain immutable metadata—including operator ID, instrument serial number, and environmental temperature—for full traceability.

Applications

• Titrations in QC/QA labs for pharmaceutical raw material testing (e.g., assay of active ingredients per USP monographs).
• Standardization of titrants (e.g., NaOH, HCl, EDTA) in accordance with ASTM E200 and ISO 3696 Grade 2 water specifications.
• Dairy analysis: SH (Soxhlet-Henkel) titration for acidity determination in milk and whey—model 4760451 variant is specifically configured for °SH scale (4 °SH = 1 mL).
• Environmental testing: alkalinity and hardness titrations in wastewater per EPA Method 310.1 and ISO 9963-1.
• Academic research: teaching quantitative analytical chemistry techniques with real-time volume feedback and low inter-user variability.

FAQ

Is the Titrette® 4760151 compliant with ISO 8655-3?
Yes—the device is manufactured and tested in accordance with ISO 8655-3:2022 for piston burettes, and each unit ships with a factory calibration certificate referencing this standard.
Can I perform user calibration without external equipment?
Yes—using the included EasyCal™ software and a certified balance (Class I, readability ≤ 0.1 mg), users can execute full-range gravimetric calibration with automated calculation and certificate generation.
What maintenance intervals are recommended?
Wetted components should be inspected visually before each use; full disassembly and cleaning are recommended after every 200 cycles or weekly in high-throughput labs. Piston seals require replacement every 12 months under normal use.
Does the RS-232 interface support real-time data streaming during titration?
Yes—the interface transmits volume increments (minimum resolution 0.001 mL) at ≥10 Hz, enabling synchronization with pH meters or conductivity probes in automated titration sequences.
Is the device suitable for Class A volumetric accuracy requirements?
Yes—its stated accuracy (≤ ±0.07%) meets or exceeds the Class A tolerance for a 25 mL burette per ISO 8655-2 (±0.05 mL), provided calibration is current and environmental conditions are controlled (20 ± 2 °C, stable humidity).