Cetoni neMESYS XL 7000N Ultra-High-Pressure Precision Syringe Pump

Overview

The Cetoni neMESYS XL 7000N is an ultra-high-pressure precision syringe pump engineered for demanding microfluidic applications requiring exceptional flow stability, nanoliter-level resolution, and sustained operation under extreme pressure conditions. Based on a closed-loop servo motor drive system with integrated PID control, the neMESYS XL 7000N eliminates pulsation inherent in conventional stepper-motor-driven pumps—delivering true continuous flow across its entire operational range. Its core architecture enables precise volumetric displacement at pressures up to 890 bar (12,900 psi), making it suitable for applications where fluid compressibility, viscosity, and system backpressure must be rigorously controlled. Unlike standard syringe pumps, the neMESYS XL 7000N is purpose-built for integration into modular, multi-pump neMESYS platforms—supporting synchronized, multi-channel fluid handling in complex experimental setups such as high-pressure chromatography, geological core flooding, or microreactor-based synthesis.

Key Features

• Ultra-stable, pulse-free fluid delivery enabled by high-resolution servo motor and real-time PID feedback control
• Maximum operating pressure of 890 bar (12,900 psi) with optional integration of FESTO pneumatic valves rated to 1370 bar (19,870 psi)
• Nanoliter-per-minute resolution: minimum controllable flow rate of 0.012 nL/min (equivalent to ~0.72 µL/h)
• Multi-syringe compatibility: supports stainless steel, PTFE-lined, and non-metallic syringes from 10 mL to 250 mL volumes
• Integrated safety shutoff housing with pressure monitoring and automatic emergency stop logic
• Standard Swagelok® 1/4″-28 UNF and 10-32 ports for leak-tight, high-pressure fluidic connections
• Modular design compliant with CANopen protocol for seamless synchronization with other Qmix modules (e.g., neMESYS Base, Qmix I/O, pressure sensors)

Sample Compatibility & Compliance

The neMESYS XL 7000N accommodates a wide range of sample chemistries—including aggressive solvents, high-viscosity polymer melts, abrasive slurries, and thermally sensitive biological reagents—when paired with appropriate syringe materials and wetted-path components. Its stainless steel body and pressure-rated fluid path meet DIN EN ISO 13849-1 (PL e) functional safety requirements. When operated with QmixElements software, the system supports ALCOA+ data integrity principles and provides full electronic audit trails, user access controls, and timestamped event logs—facilitating compliance with FDA 21 CFR Part 11, EU Annex 11, and GLP/GMP documentation standards. The pump’s mechanical design conforms to CE marking directives for machinery (2006/42/EC) and electromagnetic compatibility (2014/30/EU).

Software & Data Management

Control and orchestration are managed through QmixElements—a modular, scriptable desktop application built on Qt and optimized for scientific workflow automation. Key capabilities include real-time graphical pressure and flow-rate visualization, drag-and-drop syringe configuration, programmable ramp profiles, and conditional logic execution (e.g., trigger valve actuation upon reaching target pressure). The QmixSDK provides native C++/C#/Python APIs, while the LabVIEW Integration Toolkit delivers certified VIs for NI LabVIEW environments. All software modules support CSV and HDF5 export formats, enabling direct import into MATLAB, Python (Pandas), or statistical analysis platforms. System diagnostics—including motor current draw, temperature monitoring, and error-code history—are logged automatically and exportable for root-cause analysis.

Applications

• Petroleum engineering: Core flooding experiments under reservoir-relevant pressure and temperature (up to 160 °C with compatible accessories)
• Materials science: Precise dispensing of ceramic precursors, conductive inks, or UV-curable resins in additive manufacturing and coating processes
• Microfluidics & organ-on-chip: Long-duration, low-shear perfusion of endothelialized microchannels and 3D tissue constructs
• High-pressure reaction kinetics: Controlled reagent introduction into diamond-anvil cells or autoclave reactors
• Analytical chemistry: Solvent delivery for ultra-high-pressure liquid chromatography (UHPLC) and supercritical fluid systems
• Biotechnology: Automated micro-ELISA protocols, droplet generation for single-cell encapsulation, and microscale reagent dosing in CRISPR delivery assays

FAQ

What is the maximum sustainable pressure rating of the neMESYS XL 7000N pump head itself?

The pump head is rated for continuous operation at 890 bar (12,900 psi); transient peaks up to 1000 bar are permissible under controlled conditions.
Can the neMESYS XL 7000N be used with non-metallic syringes?

Yes—it supports PTFE-lined stainless steel syringes and fully non-metallic (e.g., glass/PTFE composite) syringes when configured with appropriate sealing materials and pressure derating.
Does QmixElements support automated calibration routines?

Yes—software includes guided volumetric calibration using gravimetric or optical methods, with traceable uncertainty reporting per ISO/IEC 17025 guidelines.
Is remote monitoring possible over Ethernet or industrial networks?

The pump features dual Ethernet ports supporting TCP/IP and EtherCAT; CANopen gateways enable integration into PLC-controlled laboratory infrastructure.
How is system safety enforced during overpressure events?

Hardware-based pressure cutoff switches, redundant software limit checks, and fail-safe valve actuation ensure immediate flow termination if preset thresholds are exceeded.