CoMetro CP-M Series Constant-Flow Piston Pump
| Brand | CoMetro |
|---|---|
| Model | CP-M |
| Type | Isocratic High-Pressure Liquid Chromatography Pump |
| Max Pressure | 6000 psi |
| Flow Rate Range | 0.01–10 mL/min |
| Accuracy | ±2% |
| Precision | ≤0.2% RSD |
| Dimensions | 175(H) × 225(W) × 305(D) mm |
| Weight | 11 kg |
| Power Supply | 115/230 V, 50/60 Hz |
| Wetted Materials | PEEK or 316 Stainless Steel |
| Control Interface | Keypad & RS232 Digital Communication |
| Pressure Monitoring | Optional (CP-M3xx models) |
| Flow Stability | Pulse-free via Electronic Compensation and Low-Dead-Volume Accumulator |
Overview
The CoMetro CP-M Series Constant-Flow Piston Pump is an engineered high-pressure liquid delivery system designed for precision isocratic applications in analytical and preparative chromatography, chemical synthesis, and controlled fluid dispensing environments. Based on positive displacement piston technology with electronic flow compensation, the CP-M pump delivers pulse-free, highly reproducible flow across its full operational range — eliminating the need for external dampeners or secondary flow regulation. Its core architecture integrates a brushless DC motor drive, non-contact pressure transduction, and a low-dead-volume accumulator to actively counteract compressibility effects and backpressure fluctuations. This closed-loop control strategy ensures stable volumetric output even under variable system resistance, making it suitable for integration into HPLC, SFC, and custom reaction manifolds where consistent solvent or reagent delivery is critical to method integrity.
Key Features
- Pulse-free flow generation via real-time electronic compensation and rapid-fill accumulator design
- High-pressure capability up to 6000 psi (414 bar), compatible with sub-2 µm particle-packed columns and supercritical fluid systems
- Flow accuracy of ±2% and repeatability ≤0.2% RSD over extended operation cycles
- Modular wetted path options: chemically inert PEEK or corrosion-resistant 316 stainless steel for broad solvent compatibility
- Dual-control architecture supporting local keypad operation and remote digital command via RS232 interface
- Integrated bypass valve and self-cleaning function to minimize carryover and extend seal life
- Optional pressure monitoring and programmable pressure limits (CP-M3xx variants) for enhanced system safety and fault detection
Sample Compatibility & Compliance
The CP-M pump accommodates a wide range of solvents including aqueous buffers, acetonitrile, methanol, THF, DCM, and aggressive media such as concentrated acids and bases — when configured with appropriate wetted materials. All CP-M models comply with IEC 61010-1 for laboratory equipment safety. The RS232 communication protocol supports audit-trail-capable data logging when integrated with compliant LIMS or CDS platforms. While not inherently 21 CFR Part 11 compliant, the pump’s deterministic control logic and hardware-based flow regulation support validation protocols required under GLP and GMP frameworks for method transfer and instrument qualification (IQ/OQ/PQ).
Software & Data Management
The CP-M series operates without proprietary software dependency: basic functions are accessible via front-panel keypad, while advanced sequencing (e.g., gradient initiation, flow ramping, pressure-triggered shutdown) is enabled through ASCII-command-based RS232 communication. Command syntax is documented in the technical manual and compatible with LabVIEW, Python (pySerial), MATLAB, and third-party chromatography data systems. All CP-M3xx models log real-time parameters — flow rate, actual pressure, high/low pressure thresholds, operational status, and alarm events — enabling traceable performance monitoring. Internal firmware stores calibration offsets and user-defined setpoints with non-volatile memory retention.
Applications
- Isocratic HPLC method development and routine QC analysis requiring high flow stability
- Continuous-flow chemistry reactors demanding precise stoichiometric reagent dosing
- Microfluidic platform priming and long-duration perfusion studies
- Calibration standard delivery in elemental analysis (ICP-OES, ICP-MS) and titration systems
- Teaching laboratories for demonstrating fundamental fluid dynamics, pump mechanics, and chromatographic principles
- Pharmaceutical formulation research where biocompatible PEEK flow paths meet USP Class VI requirements
FAQ
What is the minimum programmable flow rate on the CP-M210 model?
The CP-M210 supports a minimum flow rate of 0.01 mL/min with resolution down to 0.001 mL/min in digital control mode.
Can the CP-M pump be used with corrosive solvents like hydrochloric acid?
Yes — when equipped with 316 stainless steel pump heads and valves, and operated within recommended concentration and temperature limits per CoMetro’s chemical compatibility guide.
Does the pump support analog input for external flow modulation?
No — the CP-M series accepts only digital RS232 commands; analog voltage or frequency inputs are not supported.
Is pressure feedback available on all CP-M models?
Pressure sensing and display are exclusive to the CP-M3xx series; CP-M2xx models provide flow-only control without pressure monitoring.
How often does the pump require maintenance under continuous operation?
With proper solvent filtration and use of compatible mobile phases, piston seals typically last 6–12 months; detailed maintenance intervals are specified in the Operation Manual based on cumulative runtime and pressure profile.
