Domel CENTRIC MF220 Benchtop High-Speed Centrifuge

Overview

The Domel CENTRIC MF220 is a precision-engineered benchtop high-speed centrifuge designed for routine and advanced separation tasks in life science, clinical diagnostics, and pharmaceutical laboratories. It operates on the principle of sedimentation under controlled rotational force—generating relative centrifugal force (RCF) up to 24,700 × g at its maximum speed of 15,500 rpm. Its robust mechanical architecture, combined with a brushless induction motor and optimized aerodynamic rotor chamber, ensures thermal stability, low vibration, and long-term operational reproducibility—critical for sensitive biological macromolecule applications such as nucleic acid purification, protein pelleting, and subcellular fractionation.

Key Features

• High-performance brushless induction motor delivering consistent torque across the full speed range (200–15,500 rpm, adjustable in 10-rpm increments)
• Backlit LCD interface with intuitive navigation, real-time parameter display (speed, RCF, time, remaining time), and programmable method storage (up to 100 user-defined protocols)
• Dual-lock lid mechanism: manual secure closure with dual mechanical bolts and electric-assisted opening for safety and ergonomic operation
• 10-step acceleration and deceleration control—including “no-brake” option (step 0)—enabling gentle pelleting of fragile samples or rapid cooldown between runs
• Integrated point-start function for transient spin verification without timer activation
• Low-noise design (< 60 dB[A]) achieved through balanced rotor dynamics, acoustic insulation, and vibration-damping base construction
• Compact footprint (280 × 370 × 226 mm) suitable for space-constrained biosafety cabinets or shared lab benches
• Comprehensive safety compliance: automatic rotor recognition (via mechanical coding), imbalance detection, overspeed protection, and lid interlock monitoring per IEC 61010-2-020

Sample Compatibility & Compliance

The CENTRIC MF220 supports a broad spectrum of sample formats via seven interchangeable rotors—including 24 × 2 mL, 12 × 5 mL, 12 × 12 mL, 8 × 15 mL, 6 × 50 mL angle rotors, a 48-well PCR strip rotor (RA 4/PCR), and a 24-position hematocrit rotor (RH 24). All rotors are certified for use at rated speeds and RCFs, with material traceability and batch-specific validation documentation available upon request. The system meets essential regulatory requirements for GLP-compliant environments, including mechanical audit trails for run logs (accessible via USB export), and supports integration into ISO 17025-accredited workflows. While not inherently 21 CFR Part 11 compliant, its deterministic control logic and non-volatile method storage facilitate qualification for GMP-relevant applications when deployed with documented SOPs.

Software & Data Management

The centrifuge operates autonomously without external software dependency. All operational parameters—including speed, RCF, time, acceleration/deceleration profiles, and program ID—are stored in non-volatile memory. Run history (timestamp, rotor ID, speed, duration, final RCF) is retained for the last 100 cycles and exportable via USB interface in CSV format for laboratory information management system (LIMS) ingestion or internal QA review. No proprietary drivers or cloud connectivity are required; data integrity is preserved through hardware-level write-protection and cyclic redundancy check (CRC) validation during storage.

Applications

• Pelleting of mammalian cells, bacteria, and yeast for downstream lysis and extraction
• Clarification of crude lysates prior to chromatography or electrophoresis
• Isolation of extracellular vesicles (exosomes) and ribonucleoprotein complexes using high-RCF protocols
• Preparative separation of plasma components (e.g., platelet-poor plasma generation)
• Routine hematocrit determination in clinical hematology labs
• PCR tube consolidation and post-amplification cleanup in molecular diagnostics
• Stabilization of enzyme-containing fractions during bioprocessing development

FAQ

What is the maximum RCF achievable with the standard 6 × 50 mL angle rotor?
The RA 6/50 rotor achieves 4,300 × g at 6,000 rpm. For maximum RCF (24,700 × g), the RH 24 hematocrit rotor or RA 24/2 rotor must be used at 15,500 rpm.
Does the CENTRIC MF220 support automatic rotor identification?
Yes—mechanical coding on each rotor enables automatic recognition of type and maximum permissible speed, preventing unsafe over-speed conditions.
Can this centrifuge be operated inside a refrigerated room?
It is rated for ambient operation between 2 °C and 35 °C with relative humidity ≤75 %; condensation-free operation is ensured within this envelope.
Is the timer resolution adjustable below 10 seconds?
No—the minimum timer increment is 10 seconds, consistent with ISO 20515:2018 recommendations for routine centrifugation timing precision.
Are rotor certificates and calibration reports provided with purchase?
Each rotor ships with a manufacturer-issued conformity statement. Full calibration documentation (including speed and RCF verification) is available as an optional service per ISO/IEC 17025.