EYELA N-1300S Rotary Evaporator

Overview

The EYELA N-1300S Rotary Evaporator is a precision-engineered, benchtop solvent removal system designed for reproducible, scalable concentration and purification of heat-sensitive compounds in academic, pharmaceutical, and industrial R&D laboratories. Operating on the principle of reduced-pressure distillation, it combines controlled rotational motion, regulated bath heating, and efficient condensation to achieve rapid, gentle evaporation under vacuum. Its modular architecture supports integration with auxiliary systems—including vacuum controllers (e.g., NVC series), solvent recovery units (DPE-1300/DPE-1400), and temperature-controlled baths—enabling method optimization across diverse sample matrices. Built to meet stringent laboratory infrastructure requirements, the N-1300S complies with IEC 61010-1 safety standards for electrical equipment used in laboratory environments and supports GLP-aligned operational documentation when paired with compliant data logging tools.

Key Features

• Brushless DC motor ensures low-noise, maintenance-free rotation with precise speed control (10–310 rpm) and digital display feedback.
• Inclined dual-layer condenser (0.146 m² surface area) maximizes thermal transfer efficiency and minimizes solvent carryover; constructed from high-transparency borosilicate glass for visual process monitoring.
• Manual counterbalanced lift mechanism provides smooth, stepless vertical adjustment over 180 mm—facilitating safe flask coupling and alignment without mechanical strain.
• Bidirectional, timer-controlled flask rotation (forward/reverse) enhances mixing uniformity for suspensions, slurries, and powdered samples during evaporation or drying protocols.
• Flexible flask mounting: accommodates standard round-bottom flasks installed on either left or right side—improving ergonomics for both right- and left-handed operators.
• Dual bath compatibility: SB-1300 water bath (SUS304, 4.3 L, RT+5°C to 90°C) and OSB-2200 oil/water bath (PTFE-coated aluminum, 5.4 L, RT+5°C to 180°C) with concealed heating elements for easy cleaning and thermal stability.
• PTFE/Viton dual-seal vacuum interface ensures long-term leak integrity under sustained sub-atmospheric conditions (≤399.9 Pa).

Sample Compatibility & Compliance

The N-1300S handles a broad range of organic solvents (e.g., acetone, ethyl acetate, dichloromethane, methanol), aqueous solutions, and thermally labile extracts—including natural product isolates, polymer precursors, and API intermediates. Its design permits use with up to 3 L flasks (with optional thick-shaft H-type adapter), supporting batch scalability without compromising vacuum integrity. All wetted parts are chemically resistant (borosilicate glass, PTFE, Viton, SUS304), ensuring compatibility with aggressive solvents per ASTM D471 guidelines. While not intrinsically certified for hazardous area use, its construction adheres to ISO 14644-1 Class 8 cleanroom-compatible assembly practices. When operated with validated vacuum controllers and calibrated temperature sensors, the system supports IQ/OQ documentation for GMP-relevant purification workflows under FDA 21 CFR Part 11–compliant data management frameworks.

Software & Data Management

The N-1300S operates as a standalone analog-digital hybrid instrument: speed and bath temperature are set via intuitive rotary dials with real-time LED readouts—eliminating software dependencies while ensuring operational robustness. For traceable process recording, it integrates seamlessly with EYELA’s NVC-series vacuum controllers, which provide programmable vacuum ramps, endpoint detection, and RS-232/USB output for time-stamped parameter logging. When connected to validated LIMS or ELN platforms, these data streams support audit-ready reporting aligned with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). No embedded firmware or cloud connectivity is present—ensuring data sovereignty and minimizing cybersecurity exposure vectors common in fully digital evaporators.

Applications

• Concentration of natural product extracts prior to HPLC or GC-MS analysis.
• Removal of reaction solvents following Grignard, Suzuki, or esterification syntheses.
• Drying of nanoparticle suspensions and lyophilization pre-concentration steps.
• Purification of heat-labile vitamins, flavonoids, and unstable APIs under controlled thermal stress.
• Parallel solvent recovery in combinatorial chemistry workflows using DPE-series closed-loop collection.
• Teaching laboratory demonstrations of phase equilibria, vapor pressure depression, and Raoult’s law principles.

FAQ

What vacuum level is required for optimal performance with low-boiling solvents?
For solvents such as diethyl ether or pentane, a vacuum ≤133 Pa (1 mmHg) is recommended; the N-1300S achieves ≤399.9 Pa, making it suitable for most medium-to-high boiling point solvents (e.g., ethanol, THF, chloroform) when paired with an appropriate vacuum pump.
Can the N-1300S be used with corrosive solvents like concentrated HCl or HF?
No. Although PTFE and Viton seals offer broad chemical resistance, hydrochloric acid fumes and hydrofluoric acid will degrade glass components and seals. Use only with solvents listed in EYELA’s compatibility chart (e.g., acetone, toluene, DMF).
Is automatic lift functionality available as an upgrade?
No. The N-1300S uses a manual counterbalanced lift system for reliability and cost control. For motorized lift, consider the EYELA N-1300V series.
Does the unit include a vacuum pump or chiller?
No. These are external accessories. Compatible pumps include oil-free diaphragm types (e.g., EYELA C-35B); recirculating chillers should maintain coolant at ≤10°C for maximum condensation efficiency.
How often should the PTFE/Viton vacuum seal be replaced?
Under normal use (≤8 hrs/day, non-aggressive solvents), replacement is recommended every 12–18 months. Visual inspection for cracking, swelling, or compression set should guide maintenance scheduling.