Hanuo HNDTH-100G 50mL Centrifuge Tube Dry Bath Incubator

Overview

The Hanuo HNDTH-100G is a precision-engineered dry bath incubator specifically configured for 50 mL centrifuge tubes. Designed as a robust, water-free alternative to conventional water baths, it employs solid-state aluminum heating blocks with optimized thermal mass and PID-controlled feedback loops to deliver stable, uniform temperature environments across all six positions. Its operating principle relies on direct conductive heat transfer from the machined aluminum block—thermally coupled to high-efficiency resistive heaters and monitored by multiple embedded Pt100 sensors—to ensure rapid thermal response and minimal spatial gradient. This architecture eliminates risks associated with water contamination, evaporation, corrosion, or cross-sample condensation, making it suitable for applications requiring strict sample integrity, such as enzymatic reactions, serum coagulation assays, nucleic acid denaturation prior to PCR setup, and controlled thermal incubation of viscous or volatile reagents.

Key Features

• Real-time digital LCD touchscreen interface with simultaneous display of setpoint, actual block temperature (0.1°C resolution), and countdown timer (up to 99 h 59 min)
• Advanced programmable multi-step protocol capability: up to five sequential temperature/time segments, enabling complex thermal profiles without external controllers
• Integrated self-diagnostic system with audible alarm and on-screen fault code reporting for heater failure, sensor disconnect, or overtemperature events
• User-accessible temperature offset calibration function to compensate for minor systematic drift against traceable reference standards
• Quick-release, tool-free module exchange mechanism—facilitating rapid cleaning, autoclaving (module only), or adaptation to alternate tube formats via optional accessories
• Dual-layer overtemperature protection: primary electronic cutoff at 105°C and secondary mechanical thermal fuse rated at 110°C, compliant with IEC 61010-1 safety requirements
• Compact footprint (270 × 190 × 170 mm) and low power draw (150 W) support benchtop deployment in space-constrained QC labs, clinical diagnostics suites, and teaching laboratories

Sample Compatibility & Compliance

The HNDTH-100G accommodates six standard 50 mL conical centrifuge tubes (e.g., Falcon® 352070, Corning® 430829) in a vertically oriented, high-profile aluminum block engineered for minimal thermal bridging between positions. Block geometry ensures full immersion of tube bodies while maintaining secure mechanical retention during vortexing or brief agitation. All wetted surfaces are anodized aluminum (ISO 7583-compliant finish), resistant to common laboratory solvents and compatible with 70% ethanol, hydrogen peroxide vapor, and alkaline detergents for routine decontamination. The device conforms to CE marking requirements under Directive 2014/30/EU (EMC) and 2014/35/EU (LVD), and supports GLP/GMP documentation workflows through its deterministic timer logging and user-accessible calibration traceability.

Software & Data Management

While the HNDTH-100G operates as a standalone instrument without proprietary software, its control firmware supports audit-ready operation: all parameter changes—including setpoint modifications, timer resets, and calibration adjustments—are timestamped and retained in non-volatile memory for the preceding 100 events. No cloud connectivity or remote access is implemented, ensuring data sovereignty and eliminating cybersecurity exposure vectors. For regulated environments, users may integrate the unit into broader lab-wide validation protocols using third-party electronic lab notebook (ELN) systems or LIMS platforms via manual entry of batch-specific thermal parameters and observed stability metrics. Firmware updates (if released) are delivered via USB flash drive—no internet dependency required.

Applications

• Precise pre-heating of serum samples prior to coagulation time assays (e.g., PT, aPTT) in clinical chemistry
• Controlled denaturation of genomic DNA templates before restriction digestion or ligation steps
• Thermal equilibration of high-viscosity buffers (e.g., glycerol-containing storage solutions) prior to electrophoresis loading
• Stabilization of thermolabile enzymes during assay setup in molecular biology workflows
• Accelerated drying of solvent-washed precipitates in analytical sample preparation pipelines
• Standardized incubation of quality control standards in ISO/IEC 17025-accredited testing laboratories

FAQ

Is the HNDTH-100G validated for use in GMP-regulated environments?
Yes—when operated within its specified temperature range and maintained per the manufacturer’s calibration schedule (recommended annually), the unit meets foundational requirements for equipment qualification (IQ/OQ) in pharmaceutical QC settings. Its deterministic timer, calibration offset function, and fault logging support documented evidence generation.
Can the heating block be autoclaved?
The removable aluminum block is autoclavable at 121°C for 20 minutes; however, the main chassis and electronic components must never be exposed to steam or moisture. Always disassemble prior to sterilization.
What is the typical temperature recovery time after inserting cold samples?
When six ambient-temperature 50 mL tubes are inserted at 20°C into a block stabilized at 70°C, full thermal equilibrium across all positions is achieved within ≤3.5 minutes, verified per ASTM E220-19 methodology.
Does the unit support external temperature probes for independent verification?
No built-in port exists for external probe input, but calibrated handheld thermometers (e.g., Fluke 54II with immersion probe) may be used alongside the unit for periodic performance verification per ISO/IEC 17025 clause 6.4.10.
Are replacement modules available for other tube sizes?
Hanuo offers optional interchangeable blocks for 0.2 mL, 0.5 mL, 1.5/2.0 mL, 15 mL, and 50 mL formats—each manufactured to identical thermal specifications and mechanically keyed for unambiguous installation.