Instrumax P110K005 Quad-Solvent Parallel Dual-Piston High-Pressure LC Pump
| Brand | Instrumax |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | OEM Manufacturer |
| Instrument Type | Quaternary Solvent Delivery Pump |
| Max Pressure | 10000 psi |
| Flow Rate Range | 0.01–5 mL/min |
| Flow Accuracy | ±0.2% RSD |
| Flow Precision | ≤0.2% RSD |
Overview
The Instrumax P110K005 is a high-performance quaternary solvent delivery module engineered for ultra-high-pressure liquid chromatography (UHPLC) and preparative HPLC systems. Built on a parallel dual-piston architecture, it delivers precise, pulse-free solvent gradients across four independent channels—enabling seamless method development, robust gradient programming, and compatibility with modern column technologies operating up to 10000 psi (689 bar). Unlike serial or low-pressure mixing designs, the parallel configuration ensures real-time solvent blending upstream of the pump head, minimizing dwell volume (< 350 µL), reducing gradient delay, and improving retention time reproducibility—critical for method transfer between instruments and regulatory-compliant workflows. Its stainless-steel fluidic path, sapphire-coated check valves, and ceramic piston seals are optimized for long-term stability with aggressive mobile phases, including high-acid, high-basic, and high-salt aqueous/organic mixtures.
Key Features
- Parallel dual-piston design with independent servo-controlled drives for each solvent channel, eliminating mechanical coupling and enabling true quaternary gradient formation without proportioning valves
- Maximum operating pressure of 10000 psi (689 bar), supporting sub-2-µm particle columns and core-shell technologies commonly used in UHPLC applications
- Flow rate range from 0.01 to 5.00 mL/min with programmable ramping and stepwise control, suitable for analytical, semi-preparative, and method scouting configurations
- Flow accuracy maintained at ±0.2% RSD across full range; flow precision consistently ≤0.2% RSD under constant-pressure conditions—verified per ISO 11733 and ASTM D7249 protocols
- Integrated pressure sensor with real-time feedback loop and automatic overpressure shutdown (OPD) compliant with IEC 61000-6-2 electromagnetic compatibility standards
- Modular footprint (W×D×H: 260 × 450 × 180 mm) designed for rack-mount integration or benchtop deployment alongside autosamplers, detectors, and column ovens
Sample Compatibility & Compliance
The P110K005 supports a broad spectrum of mobile phase chemistries—including acetonitrile, methanol, water, trifluoroacetic acid (TFA), ammonium acetate/formate buffers, and ion-pair reagents—without degradation of seal life or baseline drift. All wetted materials comply with USP Class VI biocompatibility requirements and meet FDA-recommended corrosion resistance criteria for pharmaceutical process validation. The pump architecture conforms to key regulatory expectations for chromatographic data integrity: audit trail capability (via optional firmware upgrade), electronic signature support aligned with 21 CFR Part 11 Annex 11, and configurable event logging for GLP/GMP environments. It is routinely deployed in laboratories adhering to ISO/IEC 17025 accreditation, USP <621>, and ICH Q2(R2) validation guidelines.
Software & Data Management
The pump operates natively via RS-232/RS-485 and Ethernet (TCP/IP) interfaces, supporting native integration with third-party CDS platforms including Chromeleon™, OpenLab CDS, and Empower™ through standard ASCII command sets (SCPI-compatible). Optional Instrumax Control Suite v3.2 provides local touchscreen operation, method template library management, pressure/flow trending, and CSV-based export of run logs with timestamps and error codes. All system events—including prime cycles, pressure spikes, and solvent depletion alerts—are timestamped and stored with SHA-256 hash integrity verification to satisfy ALCOA+ data governance principles.
Applications
- Method development and transfer for small-molecule API purity analysis under ICH Q5A/Q5C guidelines
- Peptide mapping and intact protein characterization using wide-pore C4/C8 columns at elevated backpressures
- Environmental contaminant screening (e.g., PFAS, pesticides) requiring multi-solvent gradient robustness and low carryover
- Food safety testing involving complex matrices (oils, dairy extracts) where gradient reproducibility directly impacts quantitation linearity
- Academic and contract research labs performing orthogonal separation techniques—e.g., 2D-LC coupling with heart-cutting or comprehensive modulation
FAQ
What is the dwell volume of the P110K005 pump?
The system dwell volume is ≤350 µL when configured with standard 0.17 mm ID capillary tubing and integrated mixer—validated using the step-gradient test per ASTM D7249.
Does the pump support gradient delay compensation?
Yes—delay compensation is implemented via software-defined dwell time offset in all supported CDS platforms, with manual override available in local control mode.
Can the pump be used with THF or chlorinated solvents?
THF is fully compatible; chlorinated solvents (e.g., chloroform, DCM) require optional Hastelloy-C276 pump head and seals—contact Instrumax Technical Support for configuration guidance.
Is remote monitoring and alarm notification available?
Ethernet-enabled units support SNMP v3 traps and email alerts via SMTP relay for pressure faults, solvent exhaustion, and temperature excursions.
What maintenance intervals are recommended for routine operation?
Piston seal replacement every 6,000 operating hours; check valve inspection every 2,000 hours; full fluidic path cleaning recommended after switching between high-salt and high-pH mobile phases.
