Interscience JumboMix® 3500 P CC Laboratory Stomacher Homogenizer

Overview

The Interscience JumboMix® 3500 P CC is a high-capacity, programmable stomacher homogenizer engineered for precision and reproducibility in microbiological sample preparation. Based on the mechanical principle of controlled paddle-beating within sterile, single-use plastic bags, it delivers consistent, standardized disruption of solid and semi-solid food, environmental, and clinical specimens—enabling quantitative recovery of microorganisms without thermal or chemical bias. Designed for laboratories adhering to ISO 7218 (microbiology of food and animal feeding stuffs) and ISO 6887 (preparation of test samples), the JumboMix® 3500 P CC supports validated workflows aligned with FDA Bacteriological Analytical Manual (BAM) protocols. Its robust 304L stainless steel architecture ensures corrosion resistance, long-term stability in high-humidity lab environments, and compliance with GLP/GMP facility requirements.

Key Features

• Full 304L stainless steel housing for durability, cleanability, and regulatory compliance in regulated environments.
• Four selectable impact frequencies (1.5, 3, 4.5, and 6 impacts per second) enabling method optimization across diverse matrix types—from soft dairy products to dense pet food, seeds, tablets, and fibrous plant material.
• Adjustable homogenization force up to 22.6 kgf per blade stroke, ensuring effective cell release from resilient samples while minimizing shearing artifacts.
• Click & Clean™ blade system: fully detachable, autoclavable impact blades with tool-free installation; enables rapid decontamination between runs and eliminates cross-contamination risk.
• Q-Tight™ top-seal gasket design prevents leakage at the bag neck during high-force cycles—critical for maintaining containment integrity and operator safety when processing pathogenic or allergenic materials.
• Large-angle (270°) hinged door with ergonomic opening allows unobstructed access to the homogenization chamber for efficient bag loading, visual inspection, and maintenance.
• Digital interface with real-time countdown timer, memory recall for up to 10 user-defined programs, and intuitive parameter adjustment (time, speed, pause intervals).

Sample Compatibility & Compliance

The JumboMix® 3500 P CC accommodates standard ISO-compliant stomacher bags (200–3750 mL), including Interscience’s certified 2000 mL and 3500 mL formats. It supports sequential or pooled sample processing—e.g., five 25 g subsamples diluted 1:10 in a single 3500 mL bag—to improve detection sensitivity in low-level contamination scenarios. The system is validated for use with bacterial enumeration (coliforms, Salmonella, Listeria), mycotoxin extraction, and viral load preparation where mechanical lysis must preserve viability or antigenic integrity. All operational parameters are traceable and auditable, supporting 21 CFR Part 11–compliant data integrity frameworks when integrated with compliant LIMS or electronic lab notebooks.

Software & Data Management

While the JumboMix® 3500 P CC operates via an embedded microcontroller with no external software dependency, its digital interface logs run parameters (start time, duration, speed setting, cycle count) into non-volatile memory. Optional RS-232 or USB-to-serial interfaces enable integration with laboratory information management systems (LIMS) for automated audit trail generation. Timestamped run records—including operator ID input—support GLP documentation requirements and facilitate retrospective review during internal audits or regulatory inspections.

Applications

• Routine microbiological testing of raw meat, poultry, seafood, and ready-to-eat foods per ISO 6887-1 and FDA BAM Chapter 3.
• Environmental swab and sponge sample processing in food manufacturing facilities (e.g., Zone 1–3 monitoring).
• Pharmaceutical raw material testing for bioburden and objectionable organisms under USP & Ph. Eur. guidelines.
• Research applications requiring high-yield microbial recovery from complex matrices—such as probiotic capsules, pet treats, or botanical extracts.
• Public health laboratories performing outbreak investigations where batch-wise homogenization of multiple suspect samples improves throughput without sacrificing accuracy.

FAQ

What sample volumes does the JumboMix® 3500 P CC support?
It is optimized for volumes between 200 mL and 3750 mL, with validated performance using Interscience’s 2000 mL and 3500 mL sterile stomacher bags.
Is the unit compatible with international voltage standards?
The standard configuration supports 100–127 V~, 50–60 Hz. A 220–240 V~ version is available upon request for EU/UK/APAC installations.
Can the homogenization blades be sterilized?
Yes—the Click & Clean™ blades are fully autoclavable (121°C, 20 min, saturated steam) and chemically resistant to common disinfectants including 70% ethanol and sodium hypochlorite solutions.
Does the system meet FDA 21 CFR Part 11 requirements?
The device itself is not a standalone Part 11 system; however, its parameter logging capability and optional serial interface allow integration into validated, Part 11–compliant data ecosystems when paired with appropriate software controls and audit trail configurations.
How is leakage prevention ensured during high-speed operation?
The Q-Tight™ sealing system applies uniform radial compression to the bag collar using a dual-lip silicone gasket, verified to contain fluids under peak 6-impact/sec operation—even with viscous or particulate-laden suspensions.