KEZHE GOODSPE-6000 High-Throughput Fully Automated Solid Phase Extraction System

Overview

The KEZHE GOODSPE-6000 is a high-throughput, fully automated solid phase extraction (SPE) system engineered for reproducible, unattended isolation and concentration of trace analytes from large-volume liquid matrices. It operates on positive-pressure fluid delivery — eliminating reliance on vacuum manifolds — thereby ensuring precise, pulse-free flow control across all six independent extraction channels. Unlike conventional vacuum-driven systems, the GOODSPE-6000 utilizes a high-stability pneumatic pressure source coupled with dual syringe pumps (liquid and air) to deliver consistent elution kinetics, critical for quantitative recovery of semi-volatile and polar compounds. Its architecture supports both column-based (1 mL, 3 mL, 6 mL formats) and disk-based (47 mm SPE disks) configurations within a single platform, enabling method flexibility without hardware reconfiguration. Designed for regulatory compliance, it meets key requirements of U.S. EPA methods for environmental water testing (e.g., Methods 525.3, 537, and 8270), and its material compatibility (PTFE, borosilicate glass) ensures inertness toward aggressive solvents and acidic/basic eluents.

Key Features

• Six parallel, independently controlled SPE channels for true high-throughput processing — up to 6 samples concurrently with full method autonomy per channel.
• Positive-pressure fluid delivery system with integrated air and liquid syringe pumps (10 mL each), delivering flow stability ≤ ±1% RSD over 0.1–120 mL/min range.
• Non-metallic 12-position rotary valve resistant to corrosion by strong acids, bases, and halogenated solvents — eliminating valve clogging and extending service life.
• Dual-waste management: segregated aqueous and organic effluent pathways prevent cross-contamination and support safe solvent handling per OSHA and ISO 14001 guidelines.
• No check valves or complex robotic arms — simplified mechanical design reduces failure points and maintenance overhead while maintaining <0.1 mm positioning accuracy.
• Multi-step gradient elution capability with programmable air purge between solvent transitions, minimizing carryover and inter-solvent interference.
• Full method automation: automatic column conditioning, sample loading, washing, stepwise elution, and post-run system rinse — all executed without operator intervention.

Sample Compatibility & Compliance

The GOODSPE-6000 accommodates diverse aqueous and semi-aqueous matrices including groundwater, surface water, wastewater, fruit juices, dairy extracts, and pharmaceutical process streams. Its 20 mL–20 L sample volume range enables effective pre-concentration of sub-pptr analytes — particularly valuable for monitoring regulated contaminants such as PFAS, pharmaceuticals, endocrine disruptors, PCBs, PAHs, pesticides, and emerging toxins (e.g., brominated flame retardants, dioxins/furans). All wetted components are constructed from chemically inert PTFE and borosilicate glass, ensuring compatibility with acetonitrile, methanol, dichloromethane, ethyl acetate, and 0.1–10% HCl/NaOH solutions. The system satisfies functional equivalency criteria outlined in EPA SW-846 and ASTM D7782 for automated SPE, and its software audit trail functionality aligns with GLP/GMP data integrity expectations (21 CFR Part 11-ready configuration available upon request).

Software & Data Management

The GP-6000 workstation software (Windows XP/7/8 compatible) provides intuitive method development, real-time instrument status visualization, and comprehensive data logging. Users can store unlimited extraction protocols — including solvent sequences, flow profiles, pressure thresholds, and fraction collection triggers — with one-click recall and execution. The interface includes dedicated modules for sample tracking (batch ID, analyst, date/time stamp) and instrument usage logs (valve cycles, pump actuations, error history), supporting internal QA audits and laboratory accreditation (ISO/IEC 17025). Raw method files are saved in ASCII format for third-party LIMS integration via USB 2.0 interface. Software-generated reports include run summaries, calibration logs, and deviation alerts — all timestamped and digitally signed to meet ALCOA+ principles.

Applications

• Environmental Analysis: EPA-compliant extraction of pesticides, herbicides, PAHs, PCBs, brominated flame retardants, dioxins, and PFAS from drinking water, wastewater, and soil leachates.
• Food & Beverage Safety: Multi-residue analysis of veterinary drugs (sulfonamides, quinolones, macrolides), mycotoxins, plasticizers (DEHP, DINP), and illegal dyes (malachite green, crystal violet) in milk, juice, honey, and infant formula.
• Pharmaceutical QC: Isolation of active pharmaceutical ingredients (APIs), extractables/leachables from packaging, and metabolites from biological fluids (plasma, urine) prior to LC-MS/MS analysis.
• Forensic & Clinical Toxicology: Preparation of blood, urine, and tissue homogenates for detection of opioids, benzodiazepines, stimulants, and novel psychoactive substances (NPS).
• Industrial & Consumer Products: Screening of azo dyes in textiles, fragrance allergens in cosmetics, and residual solvents in electronic manufacturing materials.

FAQ

Does the GOODSPE-6000 support EPA Method 525.3 for drinking water analysis?
Yes — its positive-pressure flow control, solvent compatibility, and method automation meet all operational requirements specified in EPA Method 525.3 for GC/MS and LC/MS/MS analysis of pesticides and VOCs.
Can I use 47 mm SPE disks alongside standard columns on the same run?
Yes — the system’s universal cartridge holder accepts both cylindrical columns and disk-style formats without adapter changes; method parameters are independently assignable per channel.
Is the software compliant with 21 CFR Part 11?
The base software supports user authentication, electronic signatures, and audit trails; Part 11-compliant configuration (including role-based access and electronic record retention) is available as an optional licensed module.
What maintenance is required for the non-metallic 12-port valve?
No lubrication or periodic replacement is needed; the valve is chemically inert and rated for >500,000 cycles under typical lab conditions.
How does the system prevent cross-contamination between samples?
By maintaining physically separated solvent and sample fluid paths, performing automated post-run rinses with air and blank solvent, and routing aqueous and organic wastes through dedicated discharge lines.