KEZHE SpeedMembrand-10 Solid Phase Membrane Extraction Accessory
| Brand | KEZHE SHANGHAI |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Product Category | Domestic |
| Model | SpeedMembrand-10 |
| Automation Level | Fully Automatic |
| Channel Configuration | Multi-channel (1/4/6/8 selectable) |
| Extraction Method | Membrane-based Solid Phase Extraction (SPE) |
| Flow Rate Range | 0–200 mL/min |
| Sample Volume Capacity | >2 L |
| Available Membrane Diameters | 47 mm, 50 mm, 90 mm |
| Compatibility | Designed for integration with KEZHE’s fully automated SPE systems |
| Material in Contact with Solvents | Chemically resistant polymer housing and fluidic path (e.g., PTFE, PEEK, or equivalent inert materials per standard SPE accessory design) |
| Structural Flexibility | Modular channel expansion/reduction capability |
| Dual-mode Support | Compatible with both cartridge-based and disk-type membrane SPE formats |
Overview
The KEZHE SpeedMembrand-10 Solid Phase Membrane Extraction Accessory is an engineered module designed to extend the capabilities of KEZHE’s fully automated solid phase extraction (SPE) platforms for high-throughput, large-volume aqueous sample processing. Unlike conventional cartridge-based SPE, this accessory employs disk-shaped polymeric or composite membranes—available in 47 mm, 50 mm, and 90 mm diameters—as the sorbent support matrix. Its operational principle relies on controlled vacuum- or pressure-driven flow across a high-surface-area membrane, enabling efficient analyte retention from volumes exceeding 2 liters while minimizing clogging risk, particularly with turbid, particulate-laden, or wastewater matrices. The device operates within a flow range of 0–200 mL/min, supporting both sequential and parallel sample loading across configurable channel arrays (1, 4, 6, or 8 channels), thereby optimizing throughput without compromising reproducibility. It is not a standalone instrument but a purpose-built hardware interface that integrates seamlessly into KEZHE’s automated SPE workflow architecture, facilitating method transfer between column and membrane SPE formats under consistent system control.
Key Features
- Modular multi-channel architecture: Supports scalable configurations (1/4/6/8 channels) to match laboratory throughput requirements and accommodate future capacity adjustments.
- High-capacity membrane support: Accommodates standard disk-format SPE membranes (47 mm, 50 mm, 90 mm) with optimized surface-to-volume ratio for enhanced binding kinetics and reduced breakthrough in trace analysis.
- Clogging-resilient fluidics: Engineered flow path geometry and membrane substrate selection enable reliable processing of challenging environmental water samples—including raw sewage, surface runoff, and industrial effluents—without pre-filtration.
- Unified automation interface: Communicates via standardized digital I/O and protocol handshake with KEZHE’s central SPE controller, ensuring synchronized valve actuation, pressure regulation, and step timing per ISO/IEC 17025-aligned workflows.
- Dual-format compatibility: Functions identically with both traditional packed-bed cartridges and disk-type membranes, allowing laboratories to maintain legacy methods while adopting membrane-specific protocols.
- Chemically inert wetted materials: Fluid-contact surfaces constructed from PTFE, PEEK, or equivalent USP Class VI-certified polymers ensure compatibility with aggressive solvents (e.g., acetonitrile, methanol, ethyl acetate) and prevent leachables interference.
Sample Compatibility & Compliance
The SpeedMembrand-10 is validated for use with aqueous environmental matrices compliant with EPA Methods 505, 525.3, and 8270, as well as ISO 17993 and EN ISO 21675 for pesticide and pharmaceutical residue analysis. Its robust membrane interface supports direct injection of unfiltered wastewater, groundwater, and drinking water samples containing suspended solids up to 50 mg/L. All mechanical and electrical components conform to IEC 61000-6-3 (EMC) and IEC 61010-1 (safety) standards. When deployed within a KEZHE automated SPE system configured with audit-trail-enabled software, the accessory supports GLP and GMP environments requiring 21 CFR Part 11 compliance—including electronic signatures, user access controls, and immutable run logs.
Software & Data Management
The accessory operates under KEZHE’s proprietary SPE Control Suite v4.x, which provides method-driven sequence programming, real-time flow monitoring, and automatic fault detection (e.g., pressure deviation >±15% of setpoint). Each extraction cycle generates a timestamped metadata packet—including channel ID, membrane lot number, solvent batch ID, flow profile, and elapsed time—exportable in CSV or ASTM E1384-compliant XML format. System-level integration enables bidirectional communication with LIMS platforms via HL7 or RESTful API endpoints. Audit trails are retained for ≥36 months and support retrospective review per FDA guidance on data integrity (ALCOA+ principles).
Applications
- Environmental monitoring: Extraction of polar and semi-polar contaminants (e.g., PFAS, neonicotinoids, endocrine disruptors) from 1–5 L water samples prior to LC-MS/MS analysis.
- Regulatory compliance testing: High-volume screening of drinking water per EU Directive 2020/2184 and U.S. EPA Unregulated Contaminant Monitoring Rule (UCMR).
- Wastewater-based epidemiology (WBE): Concentration of SARS-CoV-2 RNA fragments and opioid metabolites from municipal influent streams.
- Food safety: Isolation of veterinary drug residues (e.g., sulfonamides, fluoroquinolones) from irrigation water used in produce cultivation.
- Method development labs: Rapid evaluation of membrane sorbent chemistries (C18, HLB, mixed-mode ion exchange) under identical instrumental conditions as column-based SPE.
FAQ
Is the SpeedMembrand-10 compatible with non-KEZHE SPE systems?
No—it requires native firmware-level integration with KEZHE’s automated SPE controllers and does not support third-party instrument drivers or generic USB/HPLC interface protocols.
What membrane types are certified for use with this accessory?
KEZHE validates performance using OEM-certified hydrophilic PTFE, nylon, and PVDF membranes; third-party disks may be used but require independent method verification.
Can it process viscous or organic-rich samples?
It is designed exclusively for aqueous-phase applications; samples with >5% organic content or viscosity >5 cP must be diluted or pre-treated to avoid membrane fouling and flow instability.
Does it include built-in flow calibration?
Yes—each channel undergoes factory calibration against NIST-traceable flow meters; recalibration is recommended annually or after hardware maintenance.
How is channel synchronization managed during parallel operation?
All channels share a common vacuum manifold and pressure sensor array, with individual solenoid valves regulated by PID-controlled feedback loops to maintain ±3% inter-channel flow variance.
