KEZHE VNH-1200plus Vacuum Parallel Concentrator

Overview

The KEZHE VNH-1200plus Vacuum Parallel Concentrator is an engineered solution for high-throughput, solvent-sensitive sample preparation in analytical and preparative laboratories. It operates on the principle of vacuum-assisted evaporation under controlled thermal conditions—combining gentle heating, precise vacuum regulation, and active condensation to remove volatile solvents from multiple samples simultaneously without thermal degradation. Unlike nitrogen blow-down systems, the VNH-1200plus eliminates compressed gas dependency, thereby reducing operational costs and eliminating risks associated with nitrogen displacement or oxygen depletion in enclosed lab spaces. Its design prioritizes reproducibility, cross-contamination prevention, and regulatory compliance—making it suitable for GLP, GMP, and ISO/IEC 17025 environments where traceability and process control are mandatory.

Key Features

• Vacuum-driven parallel concentration of 1–6 or 1–12 samples (standard configuration); scalable to 24 or 48 positions via custom sample racks
• Programmable 6-stage temperature gradient control (0–10 hours per stage), enabling optimized solvent removal across heterogeneous sample matrices
• Selectably heated platform: metal bath (faster response, uniform distribution) or water bath (gentler thermal profile for thermolabile analytes)
• Integrated reflux module that directs condensed solvent vapor onto tube walls, enhancing recovery of low-boiling-point or viscous residues
• Individual vacuum-sealed lid per sample rack—physically isolating each channel to prevent cross-contamination during co-concentration
• Tail-tube geometry (0.3 mL / 1 mL / 3 mL options) maintains a cold trap zone at the bottom of each vial; this preserves analyte integrity by preventing localized overheating or decomposition
• Intelligent vacuum management via large LCD controller: user-defined setpoints, ramped vacuum profiles, and real-time pressure feedback (range: 30 mbar absolute to atmospheric)
• Maintenance-free, variable-speed diaphragm vacuum pump (30 L/min flow rate) with adjustable suction rate to match solvent volatility and sample volume
• Onboard solvent condensation and recovery system—capturing >95% of evaporated solvents (e.g., methanol, acetonitrile, ethyl acetate) for reuse or safe disposal, minimizing VOC emissions
• Vortex agitation (0–250 rpm) integrated into sample carriers to accelerate mass transfer and prevent bumping or foaming during rapid solvent removal

Sample Compatibility & Compliance

The VNH-1200plus accommodates standard conical-bottom glass or polypropylene tubes (5–250 mL capacity, depending on rack configuration), with tail-tube variants ensuring quantitative endpoint detection. It supports common extraction workflows—including ASE (Accelerated Solvent Extraction), SPE (Solid-Phase Extraction), and QuEChERS—without requiring intermediate sample transfer, thereby reducing analyst error and contamination risk. All software operations comply with FDA 21 CFR Part 11 requirements: electronic signatures, immutable audit trails, user role-based access control, and full session logging. Hardware components meet IEC 61010-1 safety standards for laboratory electrical equipment. The system is compatible with ISO 17025-accredited methods for residual solvent analysis (e.g., ISO 18363 for biodiesel), pesticide residue quantification (AOAC 2007.01), and pharmaceutical impurity profiling (ICH Q2(R2)).

Software & Data Management

Control is executed via dedicated Windows-compatible software featuring intuitive workflow templates, method library storage, and real-time parameter monitoring (temperature, vacuum level, elapsed time, agitation speed). Each run generates a timestamped, digitally signed report containing full metadata: operator ID, method version, calibration status, environmental logs, and deviation alerts. Raw data files are stored in vendor-neutral CSV format for integration with LIMS or ELN platforms. The audit trail records all user actions—including parameter edits, start/stop commands, and emergency stops—with hash-verified immutability. Remote monitoring and alarm notification (email/SNMP) are supported through optional network interface modules.

Applications

• High-throughput concentration of LC-MS/MS extracts prior to reconstitution and injection
• Preparative cleanup of environmental water, soil, and sediment extracts (EPA Methods 525.3, 8270, 1613)
• Pharmaceutical stability testing samples requiring solvent removal under inert, low-thermal-stress conditions
• Metabolomics and proteomics workflows where preservation of labile post-translational modifications is critical
• Food safety labs processing multi-residue pesticide screens (EU SANTE/11312/2021)
• Forensic toxicology labs concentrating blood, urine, and tissue homogenates for GC-MS confirmation
• Academic core facilities supporting shared instrumentation with automated scheduling and usage tracking

FAQ

Can the VNH-1200plus be integrated with ASE or SPE systems?
Yes—the instrument accepts directly eluted fractions from ASE 600 or automated SPE workstations using standardized rack interfaces, eliminating manual transfer and associated volumetric errors.
What vacuum level is required for low-boiling solvents like dichloromethane?
The system achieves stable operation down to 30 mbar absolute; for highly volatile solvents, users may select dynamic vacuum ramping to avoid violent boiling or foaming.
Is solvent recovery efficiency validated?
Independent validation per ASTM D86 and ISO 3405 confirms ≥94.7% recovery for methanol, acetonitrile, and ethyl acetate under standard operating conditions.
Does the software support 21 CFR Part 11 compliance out-of-the-box?
Yes—audit trail, electronic signatures, and role-based permissions are enabled by default; no additional licensing or configuration is required.
What maintenance is required for the vacuum pump?
The diaphragm pump is oil-free and sealed; only periodic inspection of inlet filters and membrane integrity every 12 months is recommended.