LABA Fract R1 Fraction Collector

Overview

The LABA Fract R1 Fraction Collector is a compact, microprocessor-controlled laboratory automation device engineered for precise, programmable fractionation of eluent streams in chromatographic separations. Designed specifically to interface with both gas-phase-compatible and liquid-phase chromatography systems—including GC, HPLC, and preparative LC—the Fract R1 operates on a modular collection architecture that supports real-time signal-driven triggering via analog UV/VIS detector outputs or external TTL pulses. Its core functionality centers on deterministic sample segmentation based on user-defined criteria: elapsed time, discrete drop count (via optical drop sensor), or chromatographic peak detection (using configurable threshold and slope algorithms). The instrument’s robust mechanical design integrates a stepper-motor-driven XYZ positioning system, ensuring repeatable tube alignment and minimal carryover between fractions. Unlike legacy collectors reliant on fixed tray geometries, the Fract R1 accommodates interchangeable rack formats (e.g., 13 × 100 mm, 16 × 150 mm, or 96-well microplate adapters), enabling seamless integration into diverse purification and analytical workflows.

Key Features

• Triple-mode collection logic: time-based scheduling, drop-count accumulation (optical sensor resolution ±1 drop), and peak-triggered acquisition with adjustable baseline correction and dwell delay
• Modular rack compatibility: supports standard 12-, 24-, 48-, and 96-position tube configurations; optional deep-well and cryo-capable racks available
• Embedded real-time status display: 3.5-inch TFT LCD with intuitive menu navigation, parameter recall, and run progress visualization
• Programmable memory: stores up to 20 independent collection protocols with full parameter sets (start/stop conditions, tube offset, pause intervals)
• Low-voltage DC motor drive system: ensures quiet operation (<45 dB(A)), minimal heat generation, and extended service life under continuous duty cycles
• RS-232 and USB-B interfaces for bidirectional communication with chromatography data systems (CDS) and third-party controllers

Sample Compatibility & Compliance

The Fract R1 is validated for use with solvents commonly employed in gas-phase and reversed-phase chromatography—including hexane, ethyl acetate, methanol, acetonitrile, and aqueous buffers—provided tubing and seals are chemically compatible. All wetted materials (PTFE tubing, silicone gaskets, anodized aluminum chassis) conform to USP Class VI biocompatibility standards. The instrument meets IEC 61010-1:2010 safety requirements for laboratory electrical equipment and complies with FCC Part 15 Subpart B for electromagnetic emissions. While not classified as a medical device, its operational repeatability (±0.5 s timing accuracy, ±1.2° positional tolerance) satisfies GLP documentation requirements for traceable fractionation in regulated environments. It is routinely deployed in laboratories adhering to ISO/IEC 17025 quality management systems for chemical testing.

Software & Data Management

The Fract R1 operates autonomously but supports optional PC-based control via LABA FractionLink™ software (Windows 10/11, 64-bit). This application enables protocol creation with nested logic trees, remote monitoring of active runs, and export of collection logs in CSV and XML formats—including timestamps, trigger events, tube indices, and associated analog signal values. Audit trail functionality records all user-initiated changes with operator ID, timestamp, and parameter deltas—fully compliant with FDA 21 CFR Part 11 requirements when paired with validated electronic signature modules. Raw collection metadata can be ingested directly into LIMS platforms via standardized ODBC drivers or RESTful API endpoints.

Applications

• Purification of natural product extracts via flash chromatography, where multi-fraction recovery improves compound yield and reduces downstream solvent consumption
• Automated collection of volatile organic compounds (VOCs) eluting from GC systems equipped with cryo-trapping interfaces
• Preparative-scale isolation of synthetic intermediates under inert atmosphere conditions using nitrogen-purged collection chambers (optional accessory)
• High-throughput screening workflows requiring parallel fraction handling across multiple columns or gradient methods
• Method development studies involving retention time windowing and fraction pooling for mass spectrometry characterization

FAQ

Is the Fract R1 compatible with third-party chromatography detectors?
Yes—it accepts 0–10 V analog input signals and TTL-compatible digital triggers from most commercial UV, fluorescence, conductivity, and mass-selective detectors.
Can it operate without a connected computer?
Yes—the onboard microcontroller executes stored protocols independently; PC connectivity is optional for advanced configuration and data logging.
What is the maximum allowable eluent flow rate for reliable drop counting?
Optimal performance is maintained at flow rates between 0.1 and 10 mL/min; above 15 mL/min, time-based or peak-triggered modes are recommended.
Does it support temperature-controlled collection?
Not natively—but the instrument footprint and rack design allow integration with external refrigerated cabinets or Peltier-cooled trays (custom mounting brackets available upon request).
Are spare parts and service manuals available internationally?
Yes—LABA maintains an authorized global service network; OEM replacement kits (tubing, sensors, motor assemblies) ship from distribution hubs in Germany, Singapore, and the United States.