LABA SeriesIII Preparative Constant Flow Pump

Overview

The LABA SeriesIII Preparative Constant Flow Pump is an engineered solution for high-stability, high-reproducibility liquid delivery in preparative chromatography, process development, and continuous-flow synthesis applications. Built upon a dual-piston reciprocating architecture with microstepping motor control and digital logic regulation, the SeriesIII delivers true constant flow performance—minimizing pulsation through patented low-dead-volume pulse damping technology. Unlike conventional peristaltic or syringe-based systems, this pump maintains flow integrity across variable backpressures (up to 400 bar), making it suitable for both analytical-scale method scouting and semi-preparative purification (typically 10–50 mm ID columns). Its core design principle follows Couette-flow consistency and volumetric displacement fidelity, ensuring linearity and long-term calibration stability under extended operation.

Key Features

• Patented low-dead-volume pulse damping system—eliminates flow oscillation without external accumulators or passive dampeners
• Sapphire-coated plunger assembly—resists chemical erosion from organic solvents, acids, and bases; enables >10,000-hour service life under standard operating conditions
• Integrated real-time pressure sensor—displays dynamic system pressure on LED interface; supports overpressure shutdown and gradient delay monitoring
• Auto-prime and auto-clean cycle—programmable via front-panel keypad; reduces manual intervention and cross-contamination risk between runs
• RS-232 serial interface—enables bidirectional communication with third-party controllers, CDS software (e.g., Chromeleon, Empower), and PLC-based process automation systems
• Modular pump head design—supports rapid field replacement without recalibration; compatible with standard 1/4″-28 UNF inlet/outlet fittings

Sample Compatibility & Compliance

The SeriesIII accommodates a broad range of mobile phases—including aqueous buffers, acetonitrile, methanol, THF, DCM, and chlorinated solvents—without degradation of sealing integrity or flow accuracy. All wetted materials comply with USP Class VI biocompatibility standards and meet FDA 21 CFR Part 11 requirements when paired with audit-trail-enabled software. The pump’s mechanical architecture conforms to ISO 13843:2017 (chromatographic equipment—performance verification) and supports traceable calibration per ASTM D5292 (standard test method for determining flow rate accuracy of liquid chromatographic pumps). It is routinely deployed in laboratories operating under GLP and GMP frameworks, where pressure logging, method versioning, and user-access controls are mandated.

Software & Data Management

While the SeriesIII operates autonomously via its embedded keypad and LED display, its RS-232 port allows integration into validated data acquisition ecosystems. When connected to compliant chromatography data systems (CDS), it supports electronic signatures, event logging (e.g., prime cycles, pressure excursions, power interruptions), and automatic parameter synchronization. Audit trails record all configuration changes—including flow rate, pressure limits, and cleaning protocols—with timestamps and operator IDs. Firmware updates are performed via secure ASCII command protocol, preserving configuration integrity during maintenance.

Applications

• Semi-preparative HPLC purification of pharmaceutical intermediates and natural products
• Continuous-flow reaction monitoring and reagent dosing in API synthesis
• Method transfer from analytical to preparative scale with retention time preservation
• Multi-solvent gradient delivery in binary or ternary solvent systems
• Calibration reference for flowmeter validation in metrology labs
• Integration into automated fraction collection workflows with UV/ELSD detection triggers

FAQ

Does the SeriesIII support gradient programming natively?
No—it requires an external controller or CDS for gradient generation; however, its RS-232 interface enables precise synchronization with binary solvent selection valves.
What is the minimum programmable flow rate increment?
0.01 mL/min, with repeatability ≤ ±0.2% RSD over 24 hours at constant temperature (25°C ± 1°C).
Is the pump compatible with aggressive solvents like trifluoroacetic acid (TFA) or hydrochloric acid?
Yes—when equipped with optional PEEK/PTFE seals and sapphire plunger; full compatibility matrix available in Material Compatibility Guide v3.2.
Can pressure data be logged externally?
Yes—real-time pressure values (0–400 bar range) are transmitted via RS-232 at 10 Hz sampling rate and can be archived in CSV or TDMS format.
What maintenance intervals are recommended?
Plunger seal replacement every 6 months under continuous use; pulse damper inspection annually; full calibration recommended every 12 months or after 2000 operational hours.