LISICO FTIR Online Infrared Spectrometer
| Brand | LISICO |
|---|---|
| Model | Online FTIR Spectrometer |
| Type | Fourier Transform Infrared (FTIR), Online Process Analyser |
| Wavenumber Range | 8000–350 cm⁻¹ (extendable to 12,500–4000 cm⁻¹) |
| Spectral Resolution | < 0.25 cm⁻¹ |
| Wavenumber Accuracy | ≤ 0.01 cm⁻¹ |
| Interferometer | Domestic high-stability立体角镜 interferometer (permanent alignment, >10-year service life) |
| Beam Splitter | Standard KBr-coated mid-IR beam splitter (moisture-resistant option available) |
| Detector | Standard room-temperature DLaTGS |
| IR Source | Long-life ceramic source (1550 K) |
| Probe Material | Hastelloy C-22 |
| Probe Dimensions | Ø12 mm × 300 mm |
| Fiber Type | PIR-900/1000 silver halide fiber |
| Operating Temperature | −100 °C to +140 °C (custom ranges available) |
| Pressure Rating | Up to 200 bar |
| Interface | SMA connector |
| Fiber Length | 1.5 m |
| Minimum Bend Radius | 130 mm |
Overview
The LISICO FTIR Online Infrared Spectrometer is a robust, process-integrated Fourier Transform Infrared (FTIR) analyser engineered for real-time, non-invasive molecular monitoring in dynamic chemical environments. Based on Michelson-type interferometry with a permanently aligned solid-angle mirror interferometer, the system delivers high spectral fidelity and long-term stability—critical for continuous operation in pilot plants, reaction engineering labs, and GMP-compliant manufacturing facilities. Its dual-range optical architecture enables seamless switching between mid-infrared (8000–350 cm⁻¹) and extended near-infrared (12,500–4000 cm⁻¹) spectral windows using internal motorized optics—eliminating manual reconfiguration while preserving alignment integrity. The instrument’s core design prioritizes field reliability: the ceramic IR source operates at 1550 K for stable radiant output; the Hastelloy C-22 immersion probe withstands aggressive chemistries and high-pressure conditions up to 200 bar; and the silver halide (PIR-900/1000) fiber optic delivery ensures low-loss transmission across both spectral regions under thermal stress from −100 °C to +140 °C.
Key Features
- Real-time spectral acquisition with <0.25 cm⁻¹ resolution and ≤0.01 cm⁻¹ wavenumber accuracy—validated per ASTM E1421 and ISO 13702 for quantitative process spectroscopy
- Automated dual-range optical path switching: single-instrument coverage of both mid-IR functional group analysis and NIR overtone/band combination monitoring
- Modular detector configuration: standard room-temperature deuterated L-alanine triglycine sulfate (DLaTGS) for routine operation; optional liquid-nitrogen-cooled mercury cadmium telluride (MCT) for enhanced signal-to-noise ratio in low-concentration or fast-kinetic applications
- Industrial-grade immersion probe: 12 mm diameter × 300 mm length, constructed from corrosion-resistant Hastelloy C-22, rated for pressures up to 200 bar and thermal cycling across −100 °C to +140 °C
- SMA-coupled silver halide fiber optic interface with 1.5 m length and 130 mm minimum bend radius—optimized for vibration-prone reactor vessels and jacketed flow cells
- Fully configurable software architecture supporting 21 CFR Part 11-compliant audit trails, electronic signatures, and role-based access control
Sample Compatibility & Compliance
The LISICO Online FTIR is validated for direct in-situ measurement of liquids, slurries, gases, and heterogeneous reaction mixtures without sampling or dilution. Its probe-based design eliminates cross-contamination risks and preserves kinetic integrity during exothermic or catalytic reactions—including high-pressure hydrogenations, homogeneous metal-catalyzed couplings, and enzymatic biotransformations in stirred-tank reactors or loop systems. Regulatory alignment includes support for ICH Q5, Q7, and Q13 guidelines, as well as compatibility with GLP/GMP documentation workflows. All spectral data files are timestamped, digitally signed, and stored with immutable metadata—enabling full traceability for FDA, EMA, and PMDA inspections. The system meets electromagnetic compatibility (EMC) requirements per IEC 61326-1 and carries CE marking for industrial use within the European Economic Area.
Software & Data Management
The native LISICO Online IR Monitoring Software provides a modular, browser-accessible interface built on a secure client-server architecture. It supports fully automated time-series acquisition with user-defined interval scheduling (e.g., spectra every 5 seconds for rapid polymerization kinetics or every 30 minutes for batch crystallization endpoint detection). Trend analysis tools allow concurrent plotting of multiple analyte concentrations against absolute or relative time axes, with overlay-capable spectral libraries for peak assignment validation. Users may embed custom calibration models (PLS, MLR, or chemometric algorithms) directly into acquisition workflows. All annotations—such as process events, catalyst injections, or temperature shifts—are time-stamped and embedded in the HDF5-formatted data container. Export options include CSV (trend vectors), JCAMP-DX (spectra), and PDF reports with embedded spectral overlays and statistical summaries—all compliant with ALCOA+ data integrity principles.
Applications
- Pharmaceutical process understanding and QbD implementation: real-time tracking of API crystallization, polymorph transitions, and residual solvent clearance
- Fine chemical synthesis: monitoring of imine formation, esterification equilibria, and Grignard addition stoichiometry under inert atmosphere
- Catalysis R&D: quantifying active species concentration in homogeneous Rh- or Pd-catalyzed systems under elevated CO/H₂ pressure
- Polymer reaction engineering: measuring monomer conversion, branching index, and end-group evolution during free-radical or Ziegler–Natta polymerizations
- Biochemical process control: in-line monitoring of glucose consumption, acetate accumulation, and product formation in fed-batch CHO or E. coli bioreactors
- Continuous manufacturing: integration with PAT framework for real-time release testing (RTRT) of intermediate streams in multi-step API synthesis
FAQ
What spectral ranges does the LISICO Online FTIR cover, and how is range switching performed?
The system covers 8000–350 cm⁻¹ (mid-IR) by default and extends to 12,500–4000 cm⁻¹ (NIR) via an internal motorized optical module—no manual component replacement or recalibration is required.
Is the system compatible with existing plant DCS/SCADA architectures?
Yes—OPC UA and Modbus TCP protocols are supported for bidirectional data exchange with distributed control systems, enabling automated setpoint adjustment based on real-time spectral feedback.
Can the software generate 21 CFR Part 11-compliant audit trails?
Yes—the software logs all user actions, parameter changes, and data exports with immutable timestamps, operator IDs, and reason-for-change fields—fully aligned with FDA expectations for electronic records.
What maintenance intervals are recommended for the fiber optic probe assembly?
Under normal operating conditions, the PIR-900/1000 fiber requires no routine maintenance; visual inspection and spectral background verification are advised quarterly, with full probe calibration recommended annually or after mechanical impact.
Does LISICO provide method development support for quantitative process models?
Yes—application engineers offer on-site or remote assistance for PLS model development, validation per ICH Q2(R2), and transfer to production environments, including uncertainty budgeting and robustness testing.
