Metler Toledo Pipet-Lite XLS Adjustable Spacing Multichannel Pipette
| Brand | Rainin |
|---|---|
| Origin | USA |
| Model | LA6-300XLS / LA8-50XLS / LA8-1200XLS |
| Automation Level | Manual |
| Channels | 6 or 8 |
| Volume Range | 20 µL – 1,200 µL |
| Max Capacity | 1,200 µL |
| Accuracy | ±0.8 % at 50 µL, ±0.8 % at 300 µL, ±0.8 % at 1,200 µL |
| Channel Spacing Adjustment Range | 9–19 mm (6-channel), 9–14 mm (8-channel) |
| Tip System | LTS (Low Retention Standard) |
| Compliance | ISO 8655-2:2022, USP <1251>, GLP/GMP-ready documentation support |
Overview
The Mettler Toledo Pipet-Lite XLS Adjustable Spacing Multichannel Pipette is an engineered solution for high-throughput liquid handling in modern life science laboratories. Designed around the principle of mechanical precision and ergonomic reproducibility, it employs a calibrated air displacement mechanism compliant with ISO 8655-2:2022 for volumetric accuracy verification. Unlike fixed-spacing multichannel pipettes, the XLS series integrates a continuous, tool-free channel spacing adjustment system—enabling seamless transition between standard 96-well, 384-well, and non-standard plate formats without compromising volumetric fidelity. Its core architecture supports both 6-channel (LA6-300XLS) and 8-channel (LA8-50XLS and LA8-1200XLS) configurations, each calibrated across the full operational range from 20 µL to 1,200 µL. The device operates entirely manually, eliminating electronic dependencies while maintaining traceable performance through embedded RFID-enabled calibration history tracking when paired with Rainin’s Proline+ or LiteTouch software platforms.
Key Features
- Continuous adjustable inter-channel spacing: 9–19 mm for 6-channel models; 9–14 mm for 8-channel models—achieved via dual-control mechanism (limit + fine-tuning dials) ensuring repeatable, lockable positioning.
- LTS (Low Retention Standard) tip interface: Patented coaxial seal design guarantees consistent, leak-free engagement across all channels—no manual tightening or rocking required.
- Millimeter-scaled visual indicator on spacing adjustment collar: Enables direct, estimation-free readout of set spacing value for rapid setup and audit readiness.
- ISO 8655-2:2022 certified accuracy: ±0.8 % at key volume points (50 µL, 300 µL, 1200 µL), verified under controlled environmental conditions per manufacturer calibration protocol.
- RFID-tagged internal memory: Stores unique serial number, calibration date, and service history—accessible via Rainin LiteTouch reader for automated log generation aligned with GLP/GMP documentation workflows.
- Ergonomic lightweight chassis with balanced center-of-gravity: Reduces operator fatigue during extended multichannel operations typical in qPCR setup, ELISA plate filling, or cell passaging protocols.
Sample Compatibility & Compliance
The Pipet-Lite XLS accommodates standard conical polypropylene tips (10–1200 µL range) meeting ISO 8655-3:2022 dimensional tolerances. It is validated for use with aqueous buffers, cell suspensions, serum-containing media, and low-viscosity protein solutions (<10 cP). All models comply with electromagnetic compatibility (EMC) directive 2014/30/EU and are CE-marked for laboratory instrumentation. Calibration documentation adheres to USP requirements for analytical instrument qualification. When integrated into regulated environments, the RFID logging capability supports 21 CFR Part 11-compliant audit trails when used with validated Rainin software versions (v3.2+).
Software & Data Management
While fully functional as a standalone manual pipette, the XLS series achieves enhanced traceability when connected to Rainin’s LiteTouch RFID reader and Proline+ software suite. This integration enables automatic capture of calibration status, user identity (via badge scan), date/time stamps, and maintenance alerts. Exportable CSV reports include serial number, last calibration date, deviation values per volume point, and technician signature fields—facilitating internal QA review and external audit preparation. Software-generated calibration certificates conform to ISO/IEC 17025:2017 reporting clauses for accredited calibration laboratories.
Applications
This pipette is routinely deployed in applications demanding spatial flexibility and volumetric consistency across multiple wells: genomic DNA library normalization prior to NGS sequencing; parallel dilution series in dose-response assays; uniform seeding of primary neurons or iPSC-derived organoids across multi-well plates; high-density ELISA plate coating; and combinatorial reagent dispensing in CRISPR screening workflows. Its ability to match variable well geometries—such as staggered microfluidic chip inlets or custom bioreactor sampling ports—makes it particularly valuable in translational research labs bridging assay development and process scale-up.
FAQ
Is the Pipet-Lite XLS compatible with non-Rainin tips?
Yes—mechanically compatible with any ISO-standard LTS tip; however, accuracy and seal integrity are guaranteed only with Rainin-certified LTS consumables.
Can spacing be adjusted mid-experiment without recalibration?
Yes—the spacing mechanism is mechanically decoupled from the piston drive train; volumetric performance remains unaffected by spacing changes.
Does the RFID tag require battery or external power?
No—it is passive RFID (13.56 MHz), powered wirelessly by the LiteTouch reader during interrogation.
What is the recommended recalibration interval under GLP conditions?
Annually or after 10,000 actuations—whichever occurs first—as defined in Rainin’s IQ/OQ/PQ validation package for regulated labs.
How does the LTS tip system improve reproducibility compared to universal-fit designs?
The coaxial alignment and tapered sleeve geometry eliminate lateral play and ensure identical immersion depth and plunger travel across all channels—critical for minimizing inter-channel CVs in sensitive applications like single-cell RNA-seq library prep.
