Metrohm 855 Robotic Automated Titration System

Overview

The Metrohm 855 Robotic Automated Titration System is a fully integrated, high-precision potentiometric titration platform engineered for laboratories requiring unattended, reproducible, and traceable quantitative chemical analysis. Built upon Metrohm’s proven Titrando titration engine — a core technology validated across decades of compliance-critical applications — the 855 system merges advanced electrochemical measurement with industrial-grade robotics. It operates on the principle of potentiometric endpoint detection, where the potential difference between a reference electrode and an indicator electrode is continuously monitored during reagent addition; inflection points in the E–V curve are used to determine stoichiometric endpoints with sub-microliter precision. Designed for GLP/GMP environments, the system supports regulated workflows including audit trail generation, electronic signatures, and full data integrity per FDA 21 CFR Part 11 requirements when paired with compliant Tiamo software configuration.

Key Features

• Modular robotic architecture accommodating up to 140 sample positions in a compact footprint — reducing laboratory spatial demand by up to 40% versus conventional benchtop titrator + autosampler configurations
• Plug-and-play integration of Titrando titration modules, burettes, dosing units, and electrode stands without recalibration or mechanical alignment
• High-accuracy syringe-driven burette delivery with certified volumetric accuracy of ±30 µL at 20 mL (0.15% RSD), traceable to national metrology standards
• Triple-parameter resolution: 0.001 pH, 0.1 mV, and 0.1 °C — enabling simultaneous monitoring of pH, redox potential, and temperature for complex multi-parameter titrations
• Support for all major titration modes: Dynamic Endpoint Titration (DET), Metrohm Enhanced Titration (MET), Set-Endpoint Titration (SET), and Static pH/ION mode for direct ion activity measurement
• Robust mechanical design with IP54-rated enclosure, corrosion-resistant fluid paths, and maintenance-free stepper motor drives for long-term operational stability

Sample Compatibility & Compliance

The 855 system handles diverse sample matrices — aqueous, alcoholic, viscous, suspended, or low-conductivity solutions — via programmable sample conditioning (stirring, heating, dosing, dilution, and blank subtraction). It complies with international standard methods including ASTM D664 (acid number), ASTM D2896 (base number), ISO 8287 (chloride in water), and USP (potentiometric assay validation). All hardware components meet CE, UL, and RoHS directives. When deployed under validated Tiamo software configuration, the system fulfills ALCOA+ data integrity principles and supports full 21 CFR Part 11 compliance through role-based access control, immutable audit trails, and electronic signature enforcement.

Software & Data Management

Control, method development, and reporting are managed exclusively through Metrohm’s Tiamo software — a validated, scalable platform supporting both single-instrument operation and enterprise-level network deployment. Tiamo provides intuitive drag-and-drop method building, real-time titration curve visualization, automatic equivalence point calculation using first-derivative or Gran plot algorithms, and customizable report templates exportable to PDF, CSV, or LIMS-compatible XML. Raw data files (.TIA) retain full metadata: instrument ID, operator, timestamp, environmental conditions, electrode calibration history, and complete sensor response logs — ensuring full traceability from measurement to final result.

Applications

The 855 Robotic Automated Titration System serves as a universal platform across pharmaceutical QC (e.g., assay of active ingredients, residual acid/base quantification), petrochemical testing (TAN/TBN analysis per ASTM D974/D2896), food & beverage quality control (titratable acidity, salt content), environmental monitoring (chloride, fluoride, alkalinity), and academic research requiring high-throughput electrochemical characterization. Pre-configured application packages — such as the 855 Robotic TAN/TBN Analyzer (Order No. 2.855.2010) or 855 Robotic Chloride Analyzer (2.855.1010) — include method templates, certified reference materials protocols, and validation documentation aligned with ISO/IEC 17025 requirements.

FAQ

What titration modes does the 855 system support?

It supports DET, MET, SET, STAT, and direct pH/ion concentration measurement — configurable via Tiamo software without hardware modification.
Is the system compatible with non-Metrohm electrodes?

Yes, provided they feature standard BNC or S7 connectors and operate within the ±1200 mV / ±120 µA input range; electrode calibration and diagnostics are fully supported.
Can the 855 be integrated into a LIMS environment?

Yes — Tiamo offers ODBC and REST API interfaces for bidirectional data exchange with laboratory information management systems.
What is the maximum sample throughput per day?

Under typical 3–5 minute/titration conditions and continuous operation, the system achieves >250 determinations per 24-hour cycle across 140 positions.
Does the system require annual recalibration?

No scheduled recalibration is required; however, periodic performance verification using certified reference standards (e.g., NIST-traceable buffers or KHP solutions) is recommended per ISO/IEC 17025 Clause 6.5.