METTLER TOLEDO G20S Smart Series Automatic Potentiometric Titrator

Overview

The METTLER TOLEDO G20S Smart Series Automatic Potentiometric Titrator is an engineered solution for routine potentiometric titration in regulated and non-regulated laboratory environments. Based on classical potentiometric endpoint detection—measuring the potential difference between a reference electrode and an indicator electrode as titrant is incrementally added—the G20S delivers high reproducibility and traceable results across acid-base, redox, precipitation (e.g., chloride, bromide), complexometric, and photometric titration modes. Designed for daily use in QC, education, and R&D labs, it integrates electrochemical measurement accuracy with intuitive operational architecture. Its compact footprint (W × D × H: 320 × 400 × 450 mm) supports benchtop deployment without sacrificing functionality, while its modular design accommodates future expansion via optional external burette drivers and Rondolino autosamplers.

Key Features

• One Click® user interface with 7-inch full-color capacitive touchscreen supporting 10 languages (English, Chinese, German, French, Spanish, Italian, Russian, Polish, Korean, Portuguese) — enabling rapid method selection and execution with minimal training.
• RFID-enabled smart burettes store critical reagent metadata (concentration, expiry, lot number, calibration history) automatically recognized upon insertion — eliminating manual entry errors and supporting audit-ready documentation.
• Dual burette capability: one integrated precision burette (standard) plus one optional external driver for auxiliary titrant delivery — ideal for back-titration or multi-reagent workflows.
• Propeller-type magnetic stirrer with adjustable speed control ensures homogeneous mixing across viscosity ranges without vortex formation or electrode shielding.
• High-resolution electrochemical measurement system: 0.1 mV / 0.001 pH resolution with 0.01% meter accuracy and 0.2 mV / 0.003 pH titration precision — meeting requirements for ISO 8655-3 (burette performance) and ASTM E2087 (potentiometric titration practice).
• GLP-compliant reporting engine: automatic generation of timestamped, user-identified PDF/CSV/XML reports with full audit trail — including electrode status, temperature compensation, drift correction, and raw potential vs. volume data.

Sample Compatibility & Compliance

The G20S accepts standard 100–250 mL titration vessels and accommodates electrodes from major manufacturers (including METTLER TOLEDO InLab® series). It supports aqueous and non-aqueous media (e.g., glacial acetic acid, ethanol-water mixtures) within operating temperature range of 5–40 °C. All firmware and software modules comply with ISO/IEC 17025:2017 clause 7.7 (method validation), and data integrity features align with FDA 21 CFR Part 11 requirements when used with LabX Express or LabX PC software. The instrument’s electronic records include immutable user login logs, electronic signatures, and change history — essential for GMP and pharmaceutical QC environments.

Software & Data Management

Data export is fully configurable via USB host port: direct printing to certified USB printers (e.g., Zebra P25, HP DeskJet), secure transfer to USB storage devices, or real-time synchronization with LabX Express (lightweight local client) or LabX PC software (network-deployable enterprise platform). LabX enables centralized method management, role-based access control, automated backup, and SQL-based query tools for trend analysis. All exported files contain embedded metadata (operator ID, instrument serial, method version, environmental conditions), satisfying ISO 15195 and CLSI EP22-A2 traceability expectations. Raw data files retain unprocessed mV/pH vs. volume curves for retrospective reprocessing.

Applications

The G20S performs standardized titrations per AOAC, USP , Ph. Eur. 2.2.20, and ASTM methods — including total acidity in foodstuffs, chloride in wastewater (Mohr method), calcium in dairy products (EDTA complexometry), peroxide value in oils, and redox titration of iron(II) with ceric sulfate. Its preloaded library (>20 validated methods) covers common industrial protocols, while customizable calculation templates support proprietary formulas (e.g., % purity, mg KOH/g, meq/g). Learning titration mode assists method development by visualizing equivalence point shifts under varying parameters — critical for optimizing new assay conditions.

FAQ

Does the G20S support regulatory compliance for pharmaceutical QC?
Yes — when paired with LabX software and configured with electronic signatures, audit trails, and secure user authentication, it fulfills FDA 21 CFR Part 11 and EU Annex 11 requirements.
Can I use third-party electrodes and burettes?
Electrodes from any manufacturer are supported; however, only METTLER TOLEDO RFID-enabled burettes provide automatic parameter recognition and full GLP traceability.
Is temperature compensation integrated?
Yes — built-in Pt1000 sensor enables automatic temperature correction for pH and potential measurements per NIST SRM guidelines.
What is the maximum sample throughput with Rondolino?
Up to 120 samples per unattended series, with programmable post-titration electrode rinsing and cup-to-cup carryover minimization.
How is method security enforced?
Methods are password-protected, version-controlled, and stored with digital signatures — preventing unauthorized modification or deletion without administrator approval.