METTLER TOLEDO MS104TS/02 Analytical Balance

Overview

The METTLER TOLEDO MS104TS/02 Analytical Balance is a high-precision weighing instrument engineered for routine analytical applications in regulated and non-regulated laboratory environments. Based on electromagnetic force compensation (EMFC) technology, it delivers stable, reproducible mass measurements with 0.1 mg readability across its 120 g maximum capacity. Designed for compliance-critical workflows, the balance integrates FACT (Fully Automatic Calibration Technology) — an internal temperature- and time-triggered calibration system that maintains accuracy without manual intervention. Its robust die-cast aluminum housing ensures mechanical stability and resistance to environmental perturbations, while the 7-inch full-color capacitive touchscreen supports intuitive operation even when wearing cotton, silicone, or nitrile gloves. The MS104TS/02 meets fundamental metrological requirements outlined in ISO/IEC 17025, USP , and ASTM E898–22 for analytical balance performance verification.

Key Features

• FACT internal calibration with automatic adjustment based on ambient temperature drift and scheduled intervals — eliminates manual recalibration and ensures traceable accuracy.
• LevelControl: Real-time leveling guidance displayed directly on the touchscreen; alerts users when out-of-level condition exceeds tolerance and provides step-by-step visual instructions for rapid correction.
• MinWeigh function: Enforces minimum sample weight limits per USP and EP 2.1.7 guidelines; triggers red-digit warning if net sample mass falls below user-defined or certified thresholds (e.g., 0.16 g typical).
• Four-sample ID registration per weighing event — supports traceability through integrated barcode scanning or touchscreen input (e.g., operator ID, batch number, sample code, location).
• QuickLock draft shield: Tool-free, one-click removal and reinstallation; all components dishwasher-safe for rapid decontamination and adherence to GLP cleaning protocols.
• Password-protected configuration: Restricts access to calibration settings, MinWeigh parameters, and interface configurations to authorized personnel only — critical for audit readiness under FDA 21 CFR Part 11 and EU Annex 11.

Sample Compatibility & Compliance

The MS104TS/02 accommodates standard analytical samples in crucibles, vials, and weighing boats up to 90 mm in diameter. Its open draft shield design allows compatibility with tall containers and volumetric glassware. The balance complies with international regulatory expectations for analytical instrumentation, including ISO 9001 quality management systems, ISO/IEC 17025 accreditation criteria for testing laboratories, and pharmacopeial standards such as USP (Balance Performance Verification) and EP 2.1.7 (Minimum Weight Determination). It supports GxP-aligned workflows via audit trail-capable software integration and secure user authentication. While not certified for legal-for-trade applications, its metrological performance satisfies internal QC, R&D, and manufacturing release testing requirements where traceability and repeatability are paramount.

Software & Data Management

Equipped with PC Direct mode, the MS104TS/02 enables immediate data export to Excel or LIMS without proprietary software installation — ideal for lean lab environments. Standard interfaces include RS232, USB Device (for printer or storage), and USB Host (for keyboard or barcode reader). Bluetooth connectivity is available as an optional module for wireless integration with mobile devices or central data loggers. All data transfers support timestamped records with operator ID embedding. When connected to METTLER TOLEDO LabX software (sold separately), the balance fully supports electronic signatures, automated report generation, SOP-driven workflows, and 21 CFR Part 11-compliant audit trails — including full change history of calibration events, parameter modifications, and weighing records.

Applications

This analytical balance serves core functions across pharmaceutical quality control labs (e.g., assay preparation, reference standard weighing, dissolution tablet sampling), chemical synthesis (reagent dispensing, stoichiometric calculations), materials science (powder density determination, catalyst loading), and food safety testing (nutrient fortification verification, allergen threshold checks). Its fast stabilization time (2 s), low minimum weight (0.16 g), and high repeatability (0.1 mg at 100 g) make it suitable for high-throughput environments requiring consistent precision across shifts. The ergonomic touchscreen interface and glove-compatible operation further enhance usability in cleanrooms, fume hoods, and production floor settings where PPE use is mandatory.

FAQ

What calibration method does the MS104TS/02 use?
It employs FACT (Fully Automatic Calibration Technology), combining internal motorized calibration weights with real-time temperature monitoring to initiate recalibration automatically when thermal drift exceeds preset thresholds.
Is this balance compliant with USP requirements?
Yes — its repeatability (0.1 mg at 100 g), minimum weight capability (0.16 g typical), and built-in MinWeigh functionality align with USP criteria for analytical balance qualification and ongoing performance verification.
Can I connect the balance to a networked LIMS without third-party software?
Via USB Host or RS232, raw data can be exported in ASCII format for direct ingestion into LIMS; however, full metadata enrichment (e.g., user ID, timestamp, calibration status) requires LabX or custom middleware integration.
Does the balance support GLP-compliant record keeping?
When used with LabX software, it provides full audit trail, electronic signature, and secure archiving capabilities meeting GLP and GMP documentation standards; standalone operation retains timestamped weighing data but lacks configurable audit logging.
What is the material of the weighing pan and base plate?
The pan is stainless steel (grade 304); the base plate and main chassis are constructed from die-cast aluminum alloy for dimensional stability and long-term resistance to mechanical fatigue.