METTLER TOLEDO RAININ Pipet-One / LTS / XLS Series Manual Pipettes

Overview

The METTLER TOLEDO RAININ Pipet-One, LTS, and XLS series represent a family of high-precision, manually operated single-channel pipettes engineered for reproducible liquid handling across research, clinical diagnostics, pharmaceutical QC, and academic laboratories. These instruments operate on the air displacement principle—where piston-driven volume displacement creates negative pressure to aspirate and dispense aqueous or low-viscosity liquids with traceable accuracy. Designed in accordance with ISO 8655–1 through –6, each model integrates mechanical precision engineering with ergonomic science to minimize operator fatigue and inter-user variability. The Pipet-One serves as an entry-level calibrated platform; the LTS line introduces the patented Low-Torque Seal system for consistent tip attachment/sealing without O-rings; and the XLS series delivers enhanced durability, fine-tuned volume adjustment, and extended service life under rigorous daily use. All models are manufactured in the United States and undergo individual factory calibration with documented uncertainty values traceable to NIST standards.

Key Features

• ISO 8655-compliant accuracy and precision: Typical coefficient of variation (CV) ≤ 0.8% at nominal volume for water at 20 °C
• LTS (Low-Torque Seal) technology: Eliminates reliance on O-ring seals; ensures uniform tip seating force and hermetic seal across all RAININ LTS tips—reducing channel-to-channel variability in multichannel workflows
• Ergonomic design: Curved finger hook, balanced weight distribution, and low tip ejection force (<15 N) validated per ISO 8655–6 for sustained user comfort during repetitive operations
• Volumetric range flexibility: Available from 0.1 µL to 10 mL across Pipet-One (0.1–1000 µL), LTS (0.5–10,000 µL), and XLS (1–10,000 µL) variants
• Mechanical volume lock: Prevents accidental volume drift during handling or transport; accessible via side-mounted lever or dial-integrated mechanism
• Chemical resistance: Housing constructed from autoclavable polypropylene and corrosion-resistant stainless steel components; compatible with 70% ethanol, isopropanol, and dilute sodium hypochlorite

Sample Compatibility & Compliance

These pipettes are validated for use with aqueous buffers, saline solutions, cell culture media, diluted acids/bases (pH 2–12), and low-viscosity organic solvents (e.g., methanol, acetonitrile). Performance specifications assume ambient temperature (20–25 °C), relative humidity 40–60%, and use of RAININ-certified LTS or universal conical tips. Non-LTS tips may compromise accuracy due to inconsistent sealing. All models support compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) frameworks when used with documented calibration records, maintenance logs, and traceable standards. The optional MCP Calibration Workstation enables full ISO 8655–6 verification—including gravimetric measurement, temperature/pressure/humidity correction, and automated report generation compliant with FDA 21 CFR Part 11 audit trail requirements.

Software & Data Management

While the Pipet-One, LTS, and XLS series are manual instruments requiring no embedded firmware or connectivity, their calibration lifecycle is fully supported by METTLER TOLEDO’s MCP Calibration Software. This Windows-based application manages calibration schedules, stores instrument-specific metadata (serial number, date, technician ID), and exports PDF/CSV reports aligned with ISO/IEC 17025 documentation standards. Each calibration session captures up to four replicate measurements per volume point, calculates mean deviation, repeatability (CV%), and expanded uncertainty (k=2), and flags out-of-specification results against ISO 8655 tolerance limits. Data integrity is preserved through password-protected user roles, electronic signatures, and immutable timestamped logs—meeting regulatory expectations for auditable liquid handling verification.

Applications

These pipettes serve critical functions in quantitative assay preparation (ELISA, qPCR master mixes), sample dilution series (IC50 determination), reagent dispensing in HTS workflows, cell seeding consistency, and analytical standard preparation. The LTS platform is especially suited for applications demanding high inter-operator reproducibility—such as regulated bioanalytical labs performing ligand-binding assays (LBAs) or pharmacokinetic sample analysis. The XLS series is routinely deployed in core facilities where pipette longevity and resistance to repeated sterilization cycles are essential. When paired with BioClean Ultra sterile filtered tips or low-retention hydrophobic tips, the system supports sensitive nucleic acid work, protein crystallization trials, and cytotoxic compound handling.

FAQ

Are Pipet-One, LTS, and XLS pipettes autoclavable?
Yes—fully assembled units may be autoclaved at 121 °C, 15 psi for 20 minutes; however, repeated cycles will accelerate spring fatigue. We recommend disassembly and separate autoclaving of lower components only.
What is the recommended recalibration interval?
Per ISO 8655–7, annual calibration is required for GLP/GMP environments; high-use labs (>500 operations/day) should verify quarterly. Visual inspection and functional checks should occur before each shift.
Can I use third-party tips with LTS pipettes?
RAININ LTS pipettes are optimized for RAININ LTS tips. While some third-party LTS-compatible tips may physically fit, they are not guaranteed to meet ISO 8655 sealing or accuracy requirements—and void calibration traceability.
Does the MCP Calibration Workstation support multi-channel pipettes?
Yes—the MCP platform accommodates both single- and multi-channel pipettes (up to 12 channels) and automatically adjusts measurement protocols based on channel count and volume range.
Is there a service program available for routine maintenance?
METTLER TOLEDO offers certified field service contracts including preventive maintenance, performance verification, and component replacement—aligned with ISO 8655–6 maintenance guidelines.